Utility of extracellular matrix powders in tissue engineering

Edgar, Lauren; Altamimi, Afnan; Sánchez, Marta García; Tamburrinia, Riccardo; Asthana, Amish; Gazia, Carlo; Orlando, Giuseppe

doi:10.1080/15476278.2018.1503771

Cited by 38 publications

(32 citation statements)

References 98 publications

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“…Likewise, the relatively recent field of regenerative medicine is constantly gaining ground through new outstanding findings. Specifically, the astonishing capabilities of the extracellular matrix capable of closely emulating the ideal milieu of native organs enhancing cell growth, migration and proliferation is promising to offer innovative hints for future research[132,133].…”

Section: Discussionmentioning

confidence: 99%

De novo malignancies after liver transplantation: The effect of immunosuppressionn-personal data and review of literature

Manzia¹,

Angelico²,

Gazia³

et al. 2019

WJG

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BACKGROUNDImmunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients.AIMTo study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients.METHODSA systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.RESULTSEmerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected de novo malignancies in the pediatric and adult OLT population, respectively. To date, immunosuppression withdrawal has been achieved in up to 40% and 60% of well-selected adult and pediatric recipients, respectively. In both populations, a clear benefit of immunosuppression weaning protocols on de novo malignancies is difficult to ascertain because data have not been specified in most of the clinical experiences.CONCLUSIONThe selected populations of tolerant pediatric and adult liver transplant recipients greatly benefit from immunosuppression weaning. There is still no strong clinical evidence on the usefulness of immunosuppression withdrawal in OLT recipients on malignancies. An interesting focus is represented by the complete reconstitution of the immunological pathways that could help in decreasing the incidence of de novo malignancies and may also help in treating liver transplant patients suffering from cancer.

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Section: Discussionmentioning

confidence: 99%

De novo malignancies after liver transplantation: The effect of immunosuppressionn-personal data and review of literature

Manzia¹,

Angelico²,

Gazia³

et al. 2019

WJG

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“…ECM particles have been incorporated into different biomaterials to generate scaffolds for several different types of tissue. The ECM is used to provide biochemical cues and support biological functions rather than construct a 3D environment 227. Recently tissue‐derived microparticles from the lymph nodes, cartilage, and cornea were compared for their potential to improve corneal wound healing 228.…”

Section: Materials Selectionmentioning

confidence: 99%

Designing Scaffolds for Corneal Regeneration

Ahearne

Fernández‐Pérez

Masterton

et al. 2020

Adv Funct Materials

119

109

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Corneal blindness is one of the most common causes of vision loss worldwide, affecting millions of people. To treat these patients, researchers have been examining different approaches to engineer corneal scaffolds suitable for transplantation. Scaffolds have been developed to replace part or all of the cornea depending on the patient requirements. Both acellular and cell-seeded scaffolds have been tested in animal models. Materials that have been under investigation for manufacturing scaffolds include collagen, silk fibroin, amniotic membrane, decellularized cornea, fibrin, chitosan, gelatin, agarose, alginate, and hyaluronic acid in addition to several synthetic polymers. Different combinations of materials, fiber crosslinking techniques, and incorporation of bioactive molecules have also been examined. Factors such as the physical properties, cytocompatibility, degradation behavior, and optical characteristics have to be considered when selecting a suitable scaffold material. Recent advancements in materials fabrication techniques such as bioprinting, electrospinning, and different collagen alignment techniques, allow scaffolds to be generated that more accurately mimic the structure of the corneal stroma. A number of scaffolds have commenced clinical trials to determine their suitability for corneal regeneration.

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“…Another approach uses what is called ECM powder to improve biocompatibility of different materials[92]. Cells can be directly cultured over the powder and injected into the patient or alternatively, ECM powder can be used to coat biomaterials with poor biocompatibility, improving cell engraftment after transplantation[92]. Interestingly, an osteoblast-derived ECM has proven to stimulate osteogenesis and promote bone formation[93,94].…”

Section: Optimizing Mscs Survival and Engraftmentmentioning

confidence: 99%

“…Some authors have proposed that the osteoblast-derived ECM could be used to coat titanium scaffolds[96], which have shown unparalell mechanical properties and are routinely used in bone tissue engineering for orthopaedic implants in load-bearing areas. Despite these positive aspects, the difficult production of the ECM-powder currently hinders its application[92]…”

Section: Optimizing Mscs Survival and Engraftmentmentioning

confidence: 99%

Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells

García-Sánchez¹,

Fernández²,

Rodríguez‐Rey³

et al. 2019

WJSC

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Mesenchymal stem cells (MSCs) are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing. MSC-based treatments are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of these therapeutic limitations are inefficient homing, engraftment, and osteogenic differentiation. Many studies have proposed modifications to improve MSC engraftment and osteogenic differentiation of the transplanted cells. Several strategies are aimed to improve cell resistance to the hostile microenvironment found in the recipient tissue and increase cell survival after transplantation. These strategies could range from a simple modification of the culture conditions, known as cell-preconditioning, to the genetic modification of the cells to avoid cellular senescence. Many efforts have also been done in order to enhance the osteogenic potential of the transplanted cells and induce bone formation, mainly by the use of bioactive or biomimetic scaffolds, although alternative approaches will also be discussed. This review aims to summarize several of the most recent approaches, providing an up-to-date view of the main developments in MSC-based regenerative techniques.

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Utility of extracellular matrix powders in tissue engineering

Cited by 38 publications

References 98 publications

De novo malignancies after liver transplantation: The effect of immunosuppressionn-personal data and review of literature

De novo malignancies after liver transplantation: The effect of immunosuppressionn-personal data and review of literature

Designing Scaffolds for Corneal Regeneration

Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells

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