Methylomic changes in response to micronutrient supplementation and <i>MTHFR</i> genotype

Stevens, Aaron J.; Rucklidge, Julia J.; Darling, Kathryn A; Eggleston, Matthew; Pearson, John; Kennedy, Martin A.

doi:10.2217/epi-2018-0029

Cited by 10 publications

(6 citation statements)

References 88 publications

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“…Targets that would build upon previous micronutrient studies include changes in gut microbiota 45 and methylation. 46 The role of inflammatory cytokines also merits exploration, given their association with infant negative affect when maternal cytokines levels are high in the last trimester of pregnancy. 47 Considering dietary quality and intake is important, as poor diet quality is linked with mental health issues.…”

Section: Discussionmentioning

confidence: 99%

Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial

Johnstone

Hatsu

Tost

et al. 2022

Journal of the American Academy of Child & Adolescent Psych

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Section: Discussionmentioning

confidence: 99%

Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial

Johnstone

Hatsu

Tost

et al. 2022

Journal of the American Academy of Child & Adolescent Psych

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“…It would also be useful to identify the mechanism by which the nutrients exert their effects, within the framework of triage theory or otherwise. Other research has identified that the nutrients increase diversity of the microbiome (Stevens et al, 2019) as well as show small epigenetic effects in terms of increased methylation (Stevens et al, 2018); however, biomarkers could usefully be collected before and after exposure to the nutrients/ placebo under stressful situations to better understand the impact that the nutrients may have on cortisol response.…”

Section: Discussionmentioning

confidence: 99%

Massacre, Earthquake, Flood

Rucklidge

Afzali

Kaplan

et al. 2021

International Perspectives in Psychology

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Abstract. Natural (e.g., earthquake, flood, wildfires) and human-made (e.g., terrorism, civil strife) disasters are inevitable, can cause extensive disruption, and produce chronic and disabling psychological injuries leading to formal diagnoses (e.g., post-traumatic stress disorder [PTSD]). Following natural disasters of earthquake (Christchurch, Aotearoa/New Zealand, 2010–11) and flood (Calgary, Canada, 2013), controlled research showed statistically and clinically significant reductions in psychological distress for survivors who consumed minerals and vitamins (micronutrients) in the following months. Following a mass shooting in Christchurch (March 15, 2019), where a gunman entered mosques during Friday prayers and killed and injured many people, micronutrients were offered to survivors as a clinical service based on translational science principles and adapted to be culturally appropriate. In this first translational science study in the area of nutrition and disasters, clinical results were reported for 24 clients who completed the Impact of Event Scale – Revised (IES-R), the Depression Anxiety Stress Scales (DASS), and the Modified-Clinical Global Impression (M-CGI-I). The findings clearly replicated prior controlled research. The IES-R Cohen’s d ESs were 1.1 (earthquake), 1.2 (flood), and 1.13 (massacre). Effect sizes (ESs) for the DASS subscales were also consistently positive across all three events. The M-CGI-I identified 58% of the survivors as “responders” (i.e., self-reported as “much” to “very much” improved), in line with those reported in the earthquake (42%) and flood (57%) randomized controlled trials, and PTSD risk reduced from 75% to 17%. Given ease of use and large ESs, this evidence supports the routine use of micronutrients by disaster survivors as part of governmental response.

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“…Multidimensional scaling of the top 1000 methylation values was performed using pairwise distance method for gene selection, and normalized, filtered methylation values. Hierarchical clustering was performed on a "minkowski" distance matrix calculated using the β-values for all probes, regardless of significance [83].…”

Section: Bioinformatics Analysesmentioning

confidence: 99%

Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells

Seddon

Liau

Pace

et al. 2021

Epigenetics & Chromatin

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Background Environmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by sublethal doses of hydrogen peroxide (H2O2). However, site-specific changes in DNA methylation and the reversibility of any changes have not been explored. Using bead chip array technology, differential methylation was assessed in Jurkat T-lymphoma cells following exposure to H2O2. Results Sublethal H2O2 exposure was associated with an initial genome-wide decrease in DNA methylation in replicating cells, which was largely corrected 72 h later. However, some alterations were conserved through subsequent cycles of cell division. Significant changes to the variability of DNA methylation were also observed both globally and at the site-specific level. Conclusions This research indicates that increased exposure to H2O2 can result in long-term alterations to DNA methylation patterns, providing a mechanism for environmental factors to have prolonged impact on gene expression.

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Methylomic changes in response to micronutrient supplementation and MTHFR genotype

Abstract: Micronutrient supplementation is unlikely to have a substantial biological effect on DNA methylation over 10 weeks; however, the trend toward hypermethylation that we observed is likely to become more marked with longer exposure periods.

Cited by 10 publications

References 88 publications

Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial

Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial

Massacre, Earthquake, Flood

Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells

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