The role of OCT-A in retinal disease management

Rodriguez, Francisco J.; Staurenghi, Giovanni; Gale, Richard

doi:10.1007/s00417-018-4109-3

Cited by 31 publications

(28 citation statements)

References 23 publications

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“…To our knowledge, this is the first study that addressed the PCD and NFI intrasession repeatability with the Canon OCT-HS100, and the first report of CoR and ICC for OCT-A metric NFI. Importantly, the Canon OCT-HS100 is currently the only device using a full-spectrum amplitude decorrelation algorithm; therefore, a separate evaluation was also deemed necessary 28. A strength of this study is the fact that the calculation of the quantification parameters and reasoning are described in detail.…”

Section: Discussionmentioning

confidence: 99%

Quantification and Repeatability of Vessel Density and Flux as Assessed by Optical Coherence Tomography Angiography

Pappelis

Jansonius

2019

Trans. Vis. Sci. Tech.

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Purpose To determine the intrasession repeatability (test-retest variability) of parafoveal and peripapillary perfused capillary density (PCD) and normalized flux index (NFI) as assessed with Canon OCT-HS100 angiography. Methods Pairs of optical coherence tomography angiography (OCT-A) images were obtained from the parafoveal and peripapillary region of 30 eyes of 30 healthy subjects. PCD and NFI were calculated using generic image-processing software. Macular ganglion-cell complex thickness (GCC) and peripapillary retinal nerve fiber layer thickness (RNFLT) were also recorded. Bland-Altman analysis was performed and the coefficient of repeatability (CoR) and intraclass correlation coefficient (ICC) were calculated. Correlations of parafoveal PCD/NFI with GCC and of peripapillary PCD/NFI with RNFLT were also computed. Results Mean (standard deviation) parafoveal and peripapillary PCD were 40.0% (1.8%) and 44.5% (1.3%), respectively. Corresponding values for NFI were 151.2 (6.8) and 164.2 (3.9). For PCD, ICC was 0.76 for parafoveal and 0.79 for peripapillary measurements; corresponding CoRs were 2.7% and 1.8%. Corresponding values for NFI were 0.62 and 0.67 for ICC and 13.3 and 7.0 for CoR. Average measures ICC was 0.87/0.88 and 0.76/0.80 for the parafoveal/peripapillary PCD and NFI, respectively. PCD and NFI were weakly correlated with GCC ( r = 0.39, P = 0.035; r = 0.33, P = 0.077) and moderately correlated with RNFLT ( r = 0.43, P = 0.017; r = 0.55, P = 0.002). Conclusions Repeatability of a commercially available OCT-A with generic image-processing software was good (NFI) to excellent (PCD). Our results indicate that changes surpassing the variability in healthy subjects should be easily detectable in a clinical setting. Translational Relevance Repeatability estimates provide information regarding the relevance of changes in retinal perfusion.

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Section: Discussionmentioning

confidence: 99%

Quantification and Repeatability of Vessel Density and Flux as Assessed by Optical Coherence Tomography Angiography

Pappelis

Jansonius

2019

Trans. Vis. Sci. Tech.

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“…The principle of OCTA is to use the variation in OCT signals caused by moving particles, such as red blood cells (RBC) and other blood elements, as the contrast mechanism for imaging blood flow [ 23 ]. OCTA allows a detailed examination of different vascular layers as well as important functional information on the blood supply of the retina and choroid [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients

Savastano

Crincoli

Savastano

et al. 2020

JCM

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The ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2′s) to cause multi-organ ischemia and coronavirus-induced posterior segment eye diseases in mammals gave concern about potential sight-threatening ischemia in post coronavirus disease 2019 patients. The radial peripapillary capillary plexus (RPCP) is a sensitive target due to the important role in the vascular supply of the peripapillary retinal nerve fiber layer (RNFL). Eighty patients one month after SARS-CoV-2 infection and 30 healthy patients were selected to undergo structural OCT (optical coherence tomography) and OCTA (optical coherence tomography angiography) exams. Primary outcome was a difference in RPCP perfusion density (RPCP-PD) and RPCP flow index (RPCP-FI). No significant difference was observed in age, sex, intraocular pressure (IOP) and prevalence of myopia. RPCP-PD was lower in post SARS-CoV-2 patients compared to controls. Within the post-COVID-19 group, patients with systemic arterial hypertension had lower RPCP-FI and age was inversely correlated to both RPCP-FI and RPCP-PD. Patients treated with lopinavir + ritonavir or antiplatelet therapy during admission had lower RPCP-FI and RPCP-PD. RNFL average thickness was linearly correlated to RPCP-FI and RPCP-PD within post-COVID-19 group. Future studies will be needed to address the hypothesis of a microvascular retinal impairment in individuals who recovered from SARS-CoV-2 infection.

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“…Sinyal derinliği arttıkça derin oküler yapıların görüntülenmesi kolaylaş- makta ve segmentasyon algoritmaları geliştikçe de farklı retina dolaşım sahâlârı daha net olarak görüntülenebilmektedir. Hazır olan OKTA sistemleri ile yüzeysel retina dolaşımı, derin retina dolaşımı ve koroidal dolaşım ayrıştırılabilmektedir (2,(9)(10)(11)(12) . Tüm bu gelişmeler oldukça hızlı gerçekleşmiş ve gerek donanımsal gerekse yazılımsal gelişmeler sonucunda OKTA ölçümleri sonrası kantitatif analizler yapılabilir hâle gelmiştir.…”

Section: Discussionunclassified

“…Tüm bu gelişmeler oldukça hızlı gerçekleşmiş ve gerek donanımsal gerekse yazılımsal gelişmeler sonucunda OKTA ölçümleri sonrası kantitatif analizler yapılabilir hâle gelmiştir. OKTA ile FAZ genişliği ölçümü diyabetik retinopati gibi mikrovaskülopati ile seyreden hastalıkların takibinde kullanılabilmektedir (10,12) . Fakat kalitatif ölçümlerin en önemli olanları damar dansitesi ve akım ölçümleridir.…”

Section: Discussionunclassified