Abstract:To evaluate the association between TP53 codon72 polymorphism and male infertility risk. We conducted a search on Medline, Embase, Web of Science and CNKI up to April 30, 2017. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of the association. Seven studies including 1,818 cases and 2,278 controls met the inclusion criteria. The pooled results indicated that no significant association was observed between TP53 codon72 polymorphism and male infertility risk (G versus C: OR… Show more
Background: Ischemic stroke is a common cause of death and disability
throughout the world. We aimed to evaluate the association between
polymorphisms in TBXA2R (rs4523, rs768963, rs1131882), P2Y12 (rs204693),
ADD1 (rs4961) and risk of ischemic stroke.
Methods: A comprehensive retrieval with the databases of Pubmed, Embase,
CENTRAL, CNKI and Wan fang data was conducted. The deadline was
February 1, 2019. Pooled ORs and 95% CIs were calculated by using the Z-test.
Heterogeneity between the included studies was tested using the I2 method.
Begg’s funnel plot and Egger’s linear regression were used to evaluate the
publication bias. Software STATA 12.0 (StataCorp, College Station, TX, USA)
was used for the meta-analysis and 26 studies with 5,776 cases and 8,025
controls were included.
Results: The results indicated significantly higher risk of ischemic stroke
associated with TBXA2R variant rs768963 in all genetic models (C vs T:
OR=1.27, 95% CI=1.13-1.42, P
Background: Ischemic stroke is a common cause of death and disability
throughout the world. We aimed to evaluate the association between
polymorphisms in TBXA2R (rs4523, rs768963, rs1131882), P2Y12 (rs204693),
ADD1 (rs4961) and risk of ischemic stroke.
Methods: A comprehensive retrieval with the databases of Pubmed, Embase,
CENTRAL, CNKI and Wan fang data was conducted. The deadline was
February 1, 2019. Pooled ORs and 95% CIs were calculated by using the Z-test.
Heterogeneity between the included studies was tested using the I2 method.
Begg’s funnel plot and Egger’s linear regression were used to evaluate the
publication bias. Software STATA 12.0 (StataCorp, College Station, TX, USA)
was used for the meta-analysis and 26 studies with 5,776 cases and 8,025
controls were included.
Results: The results indicated significantly higher risk of ischemic stroke
associated with TBXA2R variant rs768963 in all genetic models (C vs T:
OR=1.27, 95% CI=1.13-1.42, P
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