Psoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human 610-Quad (Illumina) in 1,139 cases with psoriasis and 1,132 controls of Han Chinese population to search for additional independent association. With four regression models obtained, two SNPs rs9468925 in HLA-C/HLA-B and rs2858881 in HLA-DQA2 were repeatedly selected in all models, suggesting that multiple loci outside PSOR1 locus were associated with psoriasis. More importantly we find that rs9468925 in HLA-C/HLA-B is associated with both psoriasis and vitiligo, providing first important evidence that two major skin diseases share a common genetic locus in the MHC, and a basis for elucidating the molecular mechanism of skin disorders.
Background: Ischemic stroke is a common cause of death and disability
throughout the world. We aimed to evaluate the association between
polymorphisms in TBXA2R (rs4523, rs768963, rs1131882), P2Y12 (rs204693),
ADD1 (rs4961) and risk of ischemic stroke.
Methods: A comprehensive retrieval with the databases of Pubmed, Embase,
CENTRAL, CNKI and Wan fang data was conducted. The deadline was
February 1, 2019. Pooled ORs and 95% CIs were calculated by using the Z-test.
Heterogeneity between the included studies was tested using the I2 method.
Begg’s funnel plot and Egger’s linear regression were used to evaluate the
publication bias. Software STATA 12.0 (StataCorp, College Station, TX, USA)
was used for the meta-analysis and 26 studies with 5,776 cases and 8,025
controls were included.
Results: The results indicated significantly higher risk of ischemic stroke
associated with TBXA2R variant rs768963 in all genetic models (C vs T:
OR=1.27, 95% CI=1.13-1.42, P
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