Usefulness of presepsin for early detection of infections in patients with hematologic disorders

Ebisawa, Kazutoshi; Koya, Junji; Nakazaki, Kumi; Arai, Shunya; Nakamura, Fumihiko; Kurokawa, Mineo

doi:10.1016/j.cca.2018.08.032

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…In this study, infection occurred mostly from POD 7 to 10. As previously reported, presepsin level increases from an earlier time point of infection, but procalcitonin and CRP levels increase after a couple of days after onset [ 12 , 15 , 16 ], which may have caused differences in AUC on POD 5 and 7. In addition, presepsin may be useful for the early detection of infectious complications, as its level increases from POD 0 to POD 1 and peaks earlier than other biomarkers.…”

Section: Discussionmentioning

confidence: 82%

“…Presepsin (soluble CD14 subtype) is a 13-kDa protein, which is a receptor for lipopolysaccharide-binding protein complexes and is produced when monocytes phagocytose bacteria [ 9 ], but its level does not increase in viral or fungal infections [ 10 , 11 ]. Presepsin is specific to bacterial infections and useful for distinguishing sepsis from non-infectious SIRS [ 12 – 14 ]. Compared with procalcitonin and CRP, presepsin is a superior diagnostic biomarker in terms of accuracy and detects infections in the earlier phase [ 12 , 13 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Presepsin is specific to bacterial infections and useful for distinguishing sepsis from non-infectious SIRS [ 12 – 14 ]. Compared with procalcitonin and CRP, presepsin is a superior diagnostic biomarker in terms of accuracy and detects infections in the earlier phase [ 12 , 13 , 15 , 16 ]. In patients with liver cirrhosis, presepsin level tends to increase with cirrhosis progression even without infection and is associated with survival rate [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Utility of Presepsin in Infections After Liver Transplantation: A Preliminary Study

et al. 2021

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Background Infectious complications after solid organ transplantation can be fatal, and early diagnosis and intervention are important. To the best of our knowledge, no study has examined the diagnostic utility of presepsin, a known accurate biomarker, for infectious complications after liver transplantation. This study aimed to evaluate the utility of presepsin for detecting infection and perioperative kinetics of presepsin after liver transplantation. Material/Methods This single-institutional prospective, observational study included 13 patients who underwent living-donor or deceased-donor liver transplantation. Perioperative serum presepsin level was measured 6 times within a week to evaluate its association with infectious complications and compare it with procalcitonin and C-reactive protein levels and leukocyte count. Postoperatively, patients were followed up for 15 days for infectious complications. Results Five of the 13 patients developed infectious complications after liver transplantation. The median time for infection diagnosis was 9 postoperative days (25 th –75 th percentile, 7–10). Presepsin levels on 5 and 7 postoperative days were significantly higher in patients with infection than in those without ( P =0.019 and P =0.011, respectively). In receiver operating characteristic analysis, area under the curve values of presepsin on 5 and 7 postoperative days (0.881 and 0.905, respectively) were higher than those of other biomarkers. The optimal cut-off value of presepsin was 1361 pg/mL on postoperative day 5 and 1375 pg/mL on postoperative day 7. Conclusions Although this study included a small number of patients, presepsin levels on postoperative days 5 and 7 may be useful indicators for infectious complications after liver transplantation.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic Utility of Presepsin in Infections After Liver Transplantation: A Preliminary Study

et al. 2021

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“…Одной из последних крупных работ в данной области является ретроспективное исследование K. Ebisawa и соавт. [69]. Авторы оценивали диагностическое и прогностическое значение ПКТ, СРБ и ПСП у пациентов с ФН после химиотерапии.…”

Section: маркеры воспаления при нейтропенииunclassified

Role of Biochemical Inflammatory Markers in Patients with Chemotherapy-Induced Neutropenia

Dubinina¹,

Саржевский²,

Mel’nichenko³

2019

Клиническая онкогематология

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The growing number of autologous and allogeneic transplantations of bone marrow and hematopoietic stem cells as well as their technological eff ectiveness give rise to drug antineoplastic therapies with increased toxicity leading to development of complications. The most serious among this sort of complications are infections. Probability of infections in patients with chemotherapy-induced neutropenia reaches 90 %. In this context the search for an optimal marker of infectious complications becomes more and more important. The present review deals with basic biochemical infl ammatory markers and the analysis of trials assessing diagnostic and prognostic value of C-reactive protein, procalcitonin, and presepsin.

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Determining the factors affecting serum presepsin level and its diagnostic utility: A cross-sectional study

Tsuchida

Okuse

et al. 2021

Journal of Infection and Chemotherapy

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Usefulness of presepsin for early detection of infections in patients with hematologic disorders

Cited by 3 publications

References 25 publications

Diagnostic Utility of Presepsin in Infections After Liver Transplantation: A Preliminary Study

Diagnostic Utility of Presepsin in Infections After Liver Transplantation: A Preliminary Study

Role of Biochemical Inflammatory Markers in Patients with Chemotherapy-Induced Neutropenia

Determining the factors affecting serum presepsin level and its diagnostic utility: A cross-sectional study

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