Grafting antibiofilm polymer hydrogel film onto catheter by SARA SI-ATRP

Zhou, Chao; Song, Hongqin; Loh, Jia Ling Celestine; She, Jueqin; Deng, Linhong; Liao, Bo

doi:10.1080/09205063.2018.1507268

Cited by 15 publications

(11 citation statements)

References 45 publications

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“…The combination has the advantages of reducing the development of resistance and the required concentrations of antifungal agents [54]. In a similar idea, Zhou et al tested three formulations of antibacterial hydrogel, which were used in the catheter coating and showed up to 99.6% activity for the bacterial biofilm [55]. Chitosan hydrogels follow the same principle in medical devices and are very effective in controlling the formation of biofilms of numerous Candida species including in vivo rat model assays [36,40].…”

Section: Discussionmentioning

confidence: 99%

Rational selection of antifungal drugs to propose a new formulation strategy to control Candida biofilm formation on venous catheters

et al. 2020

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Introduction Infections associated with medical devices are often related to colonization by Candida spp. biofilm; in this way, numerous strategies have been developed and studied, mainly in order to prevent this type of fungal growth. Aim Considering the above, the main objective of the present study is to make a rational choice of the best antifungal therapy for the in vitro treatment of the biofilm on venous catheters, proposing an innovative formulation of a film-forming system to coat the surface in order to prevent the formation of biofilms. Methodology Anidulafungin, fluconazole, voriconazole, ketoconazole, amphotericin B, and the association of anidulafungin and amphotericin B were tested against biofilms of C. albicans, C. tropicalis, and C. parapsilosis strains in microtiter plates and in a polyurethane catheter. Besides, anidulafungin, amphotericin B, and the combination of both were incorporated in a filmforming system and were evaluated against biofilm. Results The superior activity of anidulafungin was demonstrated in relation to the other antifungal agents. Although amphotericin B showed good activity, high concentrations were required. The combination showed a synergistic action, in solution and in the formulation, showing excellent results, with activity above 90%. Conclusion Due to the superiority of anidulafungin and the synergistic activity of the combination, these alternatives were the most promising options for use in a formulation proposal as a new strategy to combat the Candida spp. biofilm. These formulations demonstrated high in vitro performance in the prevention of biofilms, indicating that they are candidates with great potential for in vivo tests.

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Section: Discussionmentioning

confidence: 99%

Rational selection of antifungal drugs to propose a new formulation strategy to control Candida biofilm formation on venous catheters

et al. 2020

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“…S. mutans, 90,146 S. aureus, 147,148,150 S. epidermidis, 149,156 E. coli, 150,152,157 and C. albicans 158 biofilms are the most frequently studied subjects. The testing of biofilms at 24−48 h is described in most sources.…”

Section: ■ Qac-embedded Coatings As a Promising Strategy For Biofilm ...mentioning

confidence: 99%

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

et al. 2023

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In a previous development stage, mostly individual antibacterial activity was a target in the optimization of biologically active compounds and antiseptic agents. Although this targeting is still valuable, a new trend has appeared since the discovery of superhigh resistance of bacterial cells upon their aggregation into groups. Indeed, it is now well established that the great majority of pathogenic germs are found in the environment as surface-associated microbial communities called biofilms. The protective properties of biofilms and microbial resistance, even to high concentrations of biocides, cause many chronic infections in medical settings and lead to serious economic losses in various areas. A paradigm shift from individual bacterial targeting to also affecting more complex cellular frameworks is taking place and involves multiple strategies for combating biofilms with compounds that are effective at different stages of microbiome formation. Quaternary ammonium compounds (QACs) play a key role in many of these treatments and prophylactic techniques on the basis of both the use of individual antibacterial agents and combination technologies. In this review, we summarize the literature data on the effectiveness of using commercially available and newly synthesized QACs, as well as synergistic treatment techniques based on them. As an important focus, techniques for developing and applying antimicrobial coatings that prevent the formation of biofilms on various surfaces over time are discussed. The information analyzed in this review will be useful to researchers and engineers working in many fields, including the development of a new generation of applied materials; understanding biofilm surface growth; and conducting research in medical, pharmaceutical, and materials sciences. Although regular studies of antibacterial activity are still widely conducted, a promising new trend is also to evaluate antibiofilm activity in a comprehensive study in order to meet the current requirements for the development of highly needed practical applications.

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“…A recent study by Zhou et al scrutinized the activity of cocktail functional polymers, cationic monomer, and cross-linker deposited on the catheter surface. These combinations inflated surface hydrophilicity as well as cationic charge, expediting biofilm inhibition (Zhou et al, 2018).…”

Section: Cationic Charge Enriched Pda-fabricated Surfaces: Effect On Antimicrobial Propertiesmentioning

confidence: 99%

Recent Advances in a Polydopamine-Mediated Antimicrobial Adhesion System

et al. 2021

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The drug resistance developed by bacteria during antibiotic treatment has been a call to action for researchers and scientists across the globe, as bacteria and fungi develop ever increasing resistance to current drugs. Innovative antimicrobial/antibacterial materials and coatings to combat such infections have become a priority, as many infections are caused by indwelling implants (e.g., catheters) as well as improving postsurgical function and outcomes. Pathogenic microorganisms that can exist either in planktonic form or as biofilms in water-carrying pipelines are one of the sources responsible for causing water-borne infections. To combat this, researchers have developed nanotextured surfaces with bactericidal properties mirroring the topographical features of some natural antibacterial materials. Protein-based adhesives, secreted by marine mussels, contain a catecholic amino acid, 3,4-dihydroxyphenylalanine (DOPA), which, in the presence of lysine amino acid, empowers with the ability to anchor them to various surfaces in both wet and saline habitats. Inspired by these features, a novel coating material derived from a catechol derivative, dopamine, known as polydopamine (PDA), has been designed and developed with the ability to adhere to almost all kinds of substrates. Looking at the immense potential of PDA, this review article offers an overview of the recent growth in the field of PDA and its derivatives, especially focusing the promising applications as antibacterial nanocoatings and discussing various antimicrobial mechanisms including reactive oxygen species-mediated antimicrobial properties.

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Grafting antibiofilm polymer hydrogel film onto catheter by SARA SI-ATRP

Cited by 15 publications

References 45 publications

Rational selection of antifungal drugs to propose a new formulation strategy to control Candida biofilm formation on venous catheters

Rational selection of antifungal drugs to propose a new formulation strategy to control Candida biofilm formation on venous catheters

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

Recent Advances in a Polydopamine-Mediated Antimicrobial Adhesion System

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