The roles of endothelial nitric oxide synthase gene polymorphisms in diabetes mellitus and its associated vascular complications: a systematic review and meta-analysis

Dong, Jian; Yu, Ping; Wang, Yuhong; Zhang, Yang

doi:10.1007/s12020-018-1683-4

Cited by 25 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, associations between ANRIL variants and IS may also be modified by gene–environment interactions. However, most eligible studies ignore these potential interactions, which impeded us to perform relevant analyses accordingly [35,36]. On account of above-mentioned limitations, our findings should be cautiously interpreted.…”

Section: Discussionmentioning

confidence: 98%

Effects of ANRIL variants on the risk of ischemic stroke: a meta-analysis

et al. 2019

View full text Add to dashboard Cite

Background : Several studies investigated the relationship between antisense non-coding RNA in the INK4 locus (ANRIL) variants and the risk of ischemic stroke (IS), yet whether ANRIL variants are associated with IS remain controversial. Therefore, we performed the present study to obtain a more conclusive result. Methods: Literature retrieval was conducted in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: Eighteen studies were enrolled for analyses. Pooled overall analyses showed that rs2383206 (recessive model: P=0.002, OR = 1.22, 95%CI 1.08–1.38; allele model: P=0.003, OR = 0.90, 95%CI 0.84–0.96) and rs10757274 (allele model: P=0.006, OR = 0.91, 95%CI 0.86–0.97) variants were significantly associated with an increased risk of IS. Further subgroup analyses by ethnicity revealed that rs2383206, rs10757274 and rs10757278 variants were all significantly correlated with an increased risk of IS in Asians. Additionally, rs10757278 polymorphism was also significantly correlated with an increased risk of IS in Caucasians. Conclusions: Our findings indicated that rs2383206, rs10757274 and rs10757278 variants may impact individual susceptibility to IS in Asians. Moreover, rs10757278 polymorphism may also impact individual susceptibility to IS in Caucasians.

show abstract

Section: Discussionmentioning

confidence: 98%

Effects of ANRIL variants on the risk of ischemic stroke: a meta-analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In a Chinese Han, the rs2070744 C allele was associated with an increased risk of CAD [22]. In patients with diabetes mellitus, this allele was also associated with the risk of CAD [28]. Alternately, a multivariate analysis by Kincl et al [29] did not confirm any significant associations between the rs2070744 polymorphism and solitary CAD or CAD in combination with obesity and diabetes mellitus.…”

Section: Discussionmentioning

confidence: 98%

“…Additional analysis of BMI, waist circumference, and HDL cholesterol concentrations, performed separately in subgroups of females and males, showed significantly higher BMI values and waist circumferences in females with the rs1799983 TT vs. GT + GG genotype (median value [interquartile range]: 32 [31][32][33][34][35] vs. 27 [25][26][27][28][29][30] kg/ m 2 , p = 0.007, and 103 [98-106] vs. 92 [84-100] cm, p = 0.018, respectively). There were no associations between the above parameters and rs1799983 polymorphism in males.…”

Section: Discussionmentioning

confidence: 99%

<b><i>NOS3</i></b> Gene rs1799983 and rs2070744 Polymorphisms in Patients with Unstable Angina

Pawlik

Błaszczyk²,

Rać

et al. 2020

J Vasc Res

View full text Add to dashboard Cite

Acute coronary syndrome occurs when the heart muscle does not receive adequate oxygen and nutrients in a timely manner. Acute coronary syndromes are primarily due to atherosclerosis of the coronary arteries, i.e., coronary heart disease. Nitric oxide (NO) is synthesised from L-arginine in endothelial cells by the constitutive calcium-calmodulindependent enzyme, nitric oxide synthase (NOS), which mediates endothelium-dependent vasodilatation. Endothelial nitric oxide synthase (eNOS) is predominantly expressed in endothelial cells. Three NOS isoforms have been detected in different tissue: (1) neuronal NOS (nNOS) (NOS1), (2) eNOS (NOS2), and (3) inducible NOS (iNOS) (NOS3). These isoforms are encoded by three different genes. NOS3 is located on chromosome 7q35-36 and contains 26 exons. Previous studies have suggested that NOS3 polymorphisms may be associated with acute coronary syndromes. Therefore, the aim of the study was to examine the associations between NOS3 rs1799983 (894G/T) and rs2070744 (-786T/C) polymor-phisms and unstable angina. This study included 246 patients with unstable angina, as confirmed by coronary angiography. We also included 189 healthy controls who were also assessed by this technique. There were no significant differences in genotype distributions of NOS3 rs1799983 and rs2070744 polymorphisms in patients with unstable angina and healthy controls in both univariate and multivariate analyses. In patients with the NOS3 rs1799983 TT genotype, we observed a higher BMI (TT vs. GT + GG, p = 0.068), and in patients with the NOS3 rs2070744 TT genotype, we observed a higher waist circumference (TT vs. TC + CC, p = 0.023; TT vs. CC, p = 0.0053). These data suggest a lack of association between the NOS3 rs1799983 and rs2070744 polymorphisms and unstable angina in our patient population. However, these polymorphisms may be associated with some obesity parameters, rs1799983 in females and rs2070744 in males.

show abstract

“…This additive interaction could be due to the combination of the destructive effects on renal circulation exerted by smoking [17] and impaired renal haemodynamic balance, which is associated with KCNQ1 rs2237895 [22]. Obesity is associated with endothelial injury [23] and, coupled with vasoconstriction from reduced eNOS activity due to eNOS rs 2070744 [24], could cause a double hit on renal function.…”

Section: Discussionmentioning

confidence: 99%

Gene‐environment interaction in chronic kidney disease among people with type 2 diabetes from The Malaysian Cohort project: a case‐control study

et al. 2020

View full text Add to dashboard Cite

Aim To examine the possible gene-environment interactions between 32 single nucleotide polymorphisms and environmental factors that could modify the probability of chronic kidney disease. Methods A case-control study was conducted involving 600 people with type 2 diabetes (300 chronic kidney disease cases, 300 controls) who participated in The Malaysian Cohort project. Retrospective subanalysis was performed on the chronic kidney disease cases to assess chronic kidney disease progression from the recruitment phase. We genotyped 32 single nucleotide polymorphisms using mass spectrometry. The probability of chronic kidney disease and predicted rate of newly detected chronic kidney disease progression were estimated from the significant gene-environment interaction analyses. Results Four single nucleotide polymorphisms (eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228) and five environmental factors (age, sex, smoking, waist circumference and HDL) were significantly associated with chronic kidney disease. Gene-environment interaction analyses revealed significant probabilities of chronic kidney disease for sex (PPARGC1A rs8192678), smoking (eNOS rs2070744, PPARGC1A rs8192678 and KCNQ1 rs2237895), waist circumference (eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228) and HDL (eNOS rs2070744 and PPARGC1A rs8192678). Subanalysis indicated that the rate of newly detected chronic kidney disease progression was 133 cases per 1000 person-years (95% CI: 115, 153), with a mean follow-up period of 4.78 (SD 0.73) years. There was a significant predicted rate of newly detected chronic kidney disease progression in gene-environment interactions between KCNQ1 rs2283228 and two environmental factors (sex and BMI). Conclusions Our findings suggest that the gene-environment interactions of eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228 with specific environmental factors could modify the probability for chronic kidney disease.

show abstract

The roles of endothelial nitric oxide synthase gene polymorphisms in diabetes mellitus and its associated vascular complications: a systematic review and meta-analysis

Abstract: In conclusion, our findings indicate that rs891512, rs1799983, rs2070744, and rs869109213 polymorphisms may serve as genetic biomarkers of DM, while rs1799983, rs2070744, and rs869109213 polymorphisms may contribute to the development of vascular complications in DM.

Cited by 25 publications

References 19 publications

Effects of ANRIL variants on the risk of ischemic stroke: a meta-analysis

Effects of ANRIL variants on the risk of ischemic stroke: a meta-analysis

<b><i>NOS3</i></b> Gene rs1799983 and rs2070744 Polymorphisms in Patients with Unstable Angina

Gene‐environment interaction in chronic kidney disease among people with type 2 diabetes from The Malaysian Cohort project: a case‐control study

Contact Info

Product

Resources

About