Antioxidant capacity and biomarkers of oxidative stress in saliva of khat-chewing patients: a case-control study

Tarboush, Nafez Abu; Masoodi, Osama Al; Bdour, Suzan Al; Hassona, Yazan

doi:10.1016/j.oooo.2018.07.011

Cited by 11 publications

(14 citation statements)

References 30 publications

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“…Yen et al [ 23 ] state that suctioning of the mouth typically yields 10–50 μL neonatal saliva, whereas sponges and wick applicators may yield slightly higher volumes, directly correlated to collection time. Oxidative stress markers glutathione [ 24 ], malondialdehyde [ 24 , 25 , 26 , 27 ] catalase, protein carbonyls, glutathione peroxidase, and 8-hydroxy-2′-deoxyguanosine [ 27 ], as well as isoprotanes, isofuranes, neuroprostanes, and neurofuranes [ 28 ] have all been measured in saliva from adults. However, although sporadically mentioned as an alternative [ 5 , 29 ], the evidence of metabolomics analysis of saliva in asphyxiated neonates is sparse, if not non-existing.…”

Section: Resultsmentioning

confidence: 99%

Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach

et al. 2021

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There is a need for feasible and non-invasive diagnostics in perinatal asphyxia. Metabolomics is the study of small molecular weight products of cellular metabolism that may, directly and indirectly, reflect the level of oxidative stress. Saliva analysis is a novel approach that has a yet unexplored potential in metabolomics in perinatal asphyxia. The aim of this review was to give an overview of metabolomics studies of oxidative stress in perinatal asphyxia, particularly searching for studies analyzing non-invasively collected biofluids including saliva. We searched the databases PubMed/Medline and included 11 original human and 4 animal studies. In perinatal asphyxia, whole blood, plasma, and urine are the most frequently used biofluids used for metabolomics analyses. Although changes in oxidative stress-related salivary metabolites have been reported in adults, the utility of this approach in perinatal asphyxia has not yet been explored. Human and animal studies indicate that, in addition to antioxidant enzymes, succinate and hypoxanthine, as well acylcarnitines may have discriminatory diagnostic and prognostic properties in perinatal asphyxia. Researchers may utilize the accumulating evidence of discriminatory metabolic patterns in perinatal asphyxia to develop bedside methods to measure oxidative stress metabolites in perinatal asphyxia. Although only supported by indirect evidence, saliva might be a candidate biofluid for such point-of-care diagnostics.

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Section: Resultsmentioning

confidence: 99%

Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach

et al. 2021

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“…[ 29 ] It causes increase incidence of periodontitis and oral cancer. [ 26 ] Explanation was reported by Tarboush et al . [ 26 ] by the pro-oxidant effect of khat chewing that leads to dental caries, periodontitis, and increase oral cancer.…”

Section: Discussionmentioning

confidence: 96%

“…[ 26 ] Explanation was reported by Tarboush et al . [ 26 ] by the pro-oxidant effect of khat chewing that leads to dental caries, periodontitis, and increase oral cancer. In another study, Math et al .…”

Section: Discussionmentioning

confidence: 98%

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Risks of khat chewing on the cardiovascular, nervous, gastrointestinal, and genitourinary systems: A narrative review

Alshoabi

Hamid

Gameraddin

et al. 2022

J Family Med Prim Care

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Khat is an evergreen plant and its fresh green leaves and buds are chewed for several hours a day for its psychostimulant response. This study aimed to review the effects of khat chewing on the body. PubMed was searched for literature on the different aspects of khat chewing to summarize its effects on different body systems. The major effects of khat chewing are those on the cardiovascular system including increased blood pressure, increased heart rate, and increased risk of myocardial infarction. It causes insomnia, stress, depression, hallucination, and increased risk of brain stroke. It causes dental caries, bad oral hygiene, periodontitis, increased oral mucosal ulcers, and increased gingival bleeding and recession. Khat chewing causes loss of appetite, gastritis, constipation, and hemorrhoids, and increased risk of hepatotoxicity and liver cirrhosis. Ultimately, it causes weak micturition, decreased sperm motility and count, and low birth-weight offspring in khat chewing mothers. The published articles about khat chewing in journals indexed in the PubMed was reviewed. Inclusion criteria involved each article available with English language and have a reported new effect of khat chewing.

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“…In contrast, a case–control study among khat chewers showed no significant change in the SOD and GSH-Px levels between chewers and nonchewers. [ 25 ] A case–control study among tobacco chewers showed a significant increase and decrease in the salivary MDA and CAT levels compared to controls. [ 26 ] These results are found to be similar to the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

Salivary oxidative stress level among tobacco chewers and smokers: A comparative Study

Balasubramaniam

Arumugham

2022

J Adv Pharm Technol Res

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Antioxidant capacity and biomarkers of oxidative stress in saliva of khat-chewing patients: a case-control study

Cited by 11 publications

References 30 publications

Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach

Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach

Risks of khat chewing on the cardiovascular, nervous, gastrointestinal, and genitourinary systems: A narrative review

Salivary oxidative stress level among tobacco chewers and smokers: A comparative Study

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