Ovotransferrin enhances intestinal immune response in cyclophosphamide-induced immunosuppressed mice

Zhu, Gaoxiang; Luo, Jing; Du, Hongwu; Jiang, Yan; Tu, Yonggang; Yao, Yao; Xu, Mingsheng

doi:10.1016/j.ijbiomac.2018.08.058

Cited by 48 publications

(20 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, CTX treatment can cause many adverse reactions, including immunosuppression and myelosuppression (Wang et al, 2011). The administration of a specific CTX dose over a short period has been shown to significantly reduce the immune function of mice (Zhu et al, 2018). Therefore, an place for the immune cells to settle, where they receive antigen stimulation to produce an immune response (Sun et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…However, CTX treatment can cause many adverse reactions, including immunosuppression and myelosuppression (Wang et al., 2011 ). The administration of a specific CTX dose over a short period has been shown to significantly reduce the immune function of mice (Zhu et al., 2018 ). Therefore, an immunosuppressed mouse model was established in this study via the intraperitoneal injection of 80 mg/kg of CTX for two consecutive days to evaluate the immunomodulatory effect of Se‐SPep from three perspectives: nonspecific immunity, cellular immunity, and humoral immunity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice

Zhang

Gao

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice

Zhang

Gao

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…Mice in the model group (CTX group) also received the same saline regimen, but on days 10–12, CTX 80 mg/kg was administered intraperitoneally once daily (Zhu et al. 2018 ). The remaining three groups received SXF by gavage daily for 14 days.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model

Dou

Gong

et al. 2021

Pharmaceutical Biology

View full text Add to dashboard Cite

Context Sheng Xue Fang (SXF) has been used to treat anaemia for decades with good efficacy. Objective To study the effect and possible mechanism of SXF to restore haematopoietic function. Materials and methods Balb/c mice (10 per/group, half male, half female) were treated with SXF (three dose groups, 8.5, 17, and 22.1 g/kg) by gavage for 14 days, and cyclophosphamide (80 mg/kg) was injected on days 10–12. Only injection of cyclophosphamide (negative control) or physiological saline (blank control) were included as controls. The spleen and femur were processed for histopathology. Active components and the target of SXF were screened. The target was used for gene enrichment and protein-protein interaction (PPI) analysis. Results Red blood cell relative changes in the SXF group (low: −5.50 ± 1.58%; medium: −11.11 ± 4.15%; high: −8.81 ± 2.67%) and relative negative control (26.21 ± 2.51%) significantly increased (all p < 0.01) in female mice. Haemoglobin and red blood cell-specific volume showed the same trend. However, SXF did not have significant effects on male mice. Splenic index in the medium group (4.44 ± 0.46%) relative negative control (3.38 ± 0.10%) significantly improved ( p < 0.01) in female mice. Using network pharmacology, 77 active components and 337 targets were screened from SXF. These targets are closely related to the mitogen-activated protein kinase pathway. Conclusions SXF has good clinical application potential. However, the mechanism requires in-depth research. Our findings are of great significance in anaemia treatment and provide a new perspective for Chinese medicine research.

show abstract

“…Also, ovotransferrin promoted the expression of cytokines and the genes of TNF-a interferon-c (IFN-c), interleukin-4 (IL-4), and interleukin-10 (IL-10). Ovotransferrin enhanced the secretion of immunoglobulin A (IgA) and secretory immunoglobulin A (slgA) to promote intestinal humoral immune response and ameliorated the immune dysfunction caused by cyclophosphamide (CP) (Zhu et al, 2018). Zhu et al (2019) reported that the thymus and spleen index of ovotransferrin-treated mice significantly higher than that of the cyclophosphamide (CP)-treated mice.…”

Section: Immunomodulatory Activitymentioning

confidence: 99%

Functional properties of ovotransferrin from chicken egg white and its derived peptides: a review

Rathnapala¹,

Ahn

Abeyrathne³

2021

Food Sci Biotechnol

View full text Add to dashboard Cite

With emerging trends in the food and pharmaceutical industries, potential applications of egg-derived bioactive compounds were recognized. Ovotransferrin is a major egg white functional protein responsible for multiple bioactivities. The objectives of this review are to provide scientific evidence of the functional properties of chicken ovotransferrin and its derived peptides and to identify future research approaches and applications. Various easy, economical, and non-toxic methods have been reported to produce ovotransferrin with high yield and purity, and chemical and enzymatic approaches have been employed to release bioactive peptides. The native ovotransferrin is known to have antimicrobial, antioxidant, anticancer, and immunomodulatory activities. The peptides produced from ovotransferrin also are reported to have antioxidant, antimicrobial, antihypertensive, and anticancer properties. However, little or no application of these compounds in the food and pharmaceutical areas is available yet. Therefore, the practical application of OTF in nutraceutical and pharmaceutical areas are among the emerging areas of research.

show abstract

Ovotransferrin enhances intestinal immune response in cyclophosphamide-induced immunosuppressed mice

Cited by 48 publications

References 48 publications

Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice

Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice

Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model

Functional properties of ovotransferrin from chicken egg white and its derived peptides: a review

Contact Info

Product

Resources

About