Serum albumin or body mass index: Which prognostic factor for survival in patients with acute myeloblastic leukaemia?

Abstract

Obesity has been associated with an increased risk of developing acute myeloblastic leukaemia (AML). The outcome of AML patients could thus be dependent on their nutritional status that can be evaluated by the simple measurement of serum albumin (SA) and body mass index (BMI). These two parameters could have a value as prognostic factors to guide patients' management. We evaluated the association between SA levels, BMI, and survival, evaluated as overall survival (OS) and event-free survival. Furthermore, we investigated the association between BMI, SA, and other prognostic factors of interest in AML. This retrospective single-center study included 159 patients diagnosed with AML at Nancy Hospital between 2005 and 2013, treated with aracytine and anthracycline. Forty-four percent of patients presented with normal weight while 56% were obese/overweight. Serum albumin levels were <30 g/L for 49 patients, and ≥30 g/L for 110. Thirty-four patients with low SA levels were also obese. Favourable OS was associated with SA levels ≥30 g/L (HR = 0.467; 95% CI 0.230-0.946; P = .034) but was not impacted by the BMI. Serum albumin levels appear to be an independent prognostic factor in AML and a better parameter than BMI for evaluating the nutritional status of patients at diagnosis.

Clinical and Cytogenetical Characteristics-Related Nomograms for Assessing Outcome of Acute Myeloid Leukemia Patients Post IA Induction

“…A number of studies identi ed that increased age, poor-risk cytogenetics, anemia, hypoalbuminemia and treatment without allo-HSCT were correlated with inferior survival. [5,8,15,[26][27][28][29][30] Our ndings corroborated with those results. WBC count proved as a predictor of death in newly diagnosed AML in some studies.…”

The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Patients with Small Cell Lung Cancer Before First-Line Treatment with Etoposide and Progression-Free Survival

“…Measurements of body mass index (BMI) and serum albumin as classic indicators of nutritional status and have been previously studied as potential indicators of prognosis in patients with cancer [5,6]. Recently, the hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been described as a prognostic factor in patients with several types of malignant tumors, including in gastrointestinal cancer [7], and genitourinary cancer [8].…”

Simple acute phase protein score to predict long‐term survival in patients with acute myeloid leukemia

“…Elevated pretreatment CRP and ferritin levels were positively associated with the incidence of systemic inflammation during anti‐leukemic induction chemotherapy . Albumin was reported to be an independent prognostic factor and a superior parameter compared to the body mass index to evaluate the nutritional status in newly diagnosed AML patients . To the best of our knowledge, however, no study has investigated so far how CRP or albumin levels at diagnosis may affect survival in AML patients, and the Glasgow prognostic score has not been verified for AML patients.…”