The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Patients with Small Cell Lung Cancer Before First-Line Treatment with Etoposide and Progression-Free Survival

Shen, Xia-Bo; Zhang, Yuxin; Wang, Wei; Pan, Yueyin

doi:10.12659/msm.917968

Cited by 42 publications

(48 citation statements)

References 28 publications

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“…Unfortunately, however, survival data were not reported for the HALP score (33). The only score not including lymphocyte count is the mGPS, which is based on two other markers potentially re ecting interleukin-1β: albumin and CRP.…”

Section: Discussionmentioning

confidence: 99%

Inflammation Scores as Prognostic Biomarkers in Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Winther‐Larsen

Aggerholm‐Pedersen

Sandfeld-Paulsen

2020

Preprint

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Background: Inflammation scores based on general inflammation markers as leucocyte count or C-reactive protein have been evaluated as prognostic markers of inferior survival in several cancers. In small cell lung cancer (SCLC), however, inflammation scores are less studied. In the present study, we set out to perform a systematic review and meta-analysis investigating reported associations between inflammation scores and overall survival (OS) in SCLC. Methods: A literature search was performed in PubMed, Embase, Scopus, and Web of Science following the Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) guidelines. Of the identified publications, only studies in English containing original data evaluating inflammation scores as a prognostic factor in SCLC patients were included. Hazard ratios (HRs) for OS were pooled in a random-effects model. Results: In total, 33 articles were included evaluating eight different inflammation scores in 7762 SCLC patients. Seven of the identified scores were based on leucocyte count. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) ratio were the most frequently evaluated scores (NLR: n=23; PLR: n=22). For NLR, a meta-analysis including 16 studies demonstrated that patients with a high NLR had a significantly shorter OS compared to patients with a low NLR (pooled HR=1.39 (95 % CI, 1.23 – 1.56)). For PLR, an association with survival could not be confirmed in a meta-analysis performed based on eight studies (pooled HR=1.20 (95 % CI, 0.96 – 1.51)). Conclusions: This review identifies that inflammation scores based on general inflammation markers have some potential as prognostic biomarkers in SCLC. The meta-analyses indicated that NLR is associated with inferior OS, whereas an association between PLR and OS could not be confirmed. Thus, NLR could be a useful biomarker of OS in SCLC patients. Systematic Review Registrations: The protocol for the study was submitted to the PROSPERO database (registration number CRD42020188553).

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Section: Discussionmentioning

confidence: 99%

Inflammation Scores as Prognostic Biomarkers in Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Winther‐Larsen

Aggerholm‐Pedersen

Sandfeld-Paulsen

2020

Preprint

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“…Chen et al firstly described this score system to predict the prognosis of gastric cancer. 10 Then it was used in esophageal squamous cell carcinoma 22 , renal cell carcinoma 8 , bladder cancer 9 , prostate cancer 7 , lung cancer 23 , colorectal cancer 11 ,and pancreatic cancer 24 for predicingt the prognosis of the above-mentioned cancer types in the literature. Guo et al showed that the HALP score was an independent prognostic factor for PSA-progression free survival in patients with metastatic PCa or oligometastatic PCa after cytoreductive radical prostatectomy.…”

Section: Discussionmentioning

confidence: 99%

“…The albumin level is accepted as the indicator of nutrition status and has been shown to be a valuable prognostic factor in cancer patients. 23,28 The nutrition status would not be affected at the beginning of the cancer, and the activation of the mechanism is due to the inflammatory mediators increasing the transcapillary escape. Another mechanism is IL-6, TNF and acute phase reactants may lead to decreased production of albumin.…”

Section: Discussionmentioning

confidence: 99%

HALP Score and Albumin Levels in Men with Prostate Cancer and Benign Prostate Hyperplasia

Kaya

Çalışkan²,

Sungur

et al. 2020

Preprint

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Aims: To evaluate the diagnostic significance of the novel index combining preoperative hemoglobin, albumin levels, lymphocyte and platelet counts (HALP) in prostate cancer (PCa) patients. Methods: Between January 1, 2015 to December 31, 2018 at the Hitit University Erol Olçok Education and Research Hospital 225 patients who had undergone transrectal ultrasound guided prostate biopsy or prostate surgery were analyzed retrospectively. A total of patients; 155 had benign prostate hyperplasia (group 1) and 70 had PCa (group 2). The preoperative serum levels of hemoglobin, albumin, lymphocyte counts, and platelet counts were recorded. The HALP scores and the sub parameters of this index for each of the two groups were compared. Results: The total Prostate Specific Antigen (PSA), albumin and lymphocyte differences between the groups were statistically significant (p=0.0002, p=0.0001, p= 0.005). The median value of HALP scores in Group 1 and 2 were 49.43 and 51.2 respectively, and this was not statistically significant between groups (p=0.737). The HALP score had the least Area Under Curve (AUC) value compared to the others (0.514). the AUC of Albumin was larger than PSA for diagnostic efficacy in PCa patients (0.696-0.656). However, albumin levels were statistically significant compared to platelet count and the HALP score (p=0.0033, p=0.0068), except PSA and lymphocyte (p=0.4580, p=0.1717). Conclusion:Further prospective clinical studies that include more patients from multiple centers are needed to show the diagnostic role of the HALP score and its compounds on the patients with PCa.

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“…So far, no study has investigated the association between HALP score and AIS. Recent studies have shown that the HALP score can re ect the in ammation-nutritional status of patients [14,29], and has been proved to be an important prognostic indicator for patients with pancreatic cancer [13], esophageal squamous cell carcinoma [15], and bladder cancer [16]. Anemia and thrombosis could exacerbate in ammation while lymphocytes reduce in ammation [30].…”

Section: Discussionmentioning

confidence: 99%

“…The hemoglobin, albumin, lymphocyte and platelet (HALP) score is considered to be an easily calculated marker of systemic in ammation and nutritional status [13,14] and has been con rmed as a signi cant prognostic factor in patients with pancreatic cancer, esophageal squamous cell carcinoma, and bladder cancer [15,16]. However, it is unknown whether HALP score is associated with the adverse clinical events of AIS.…”

Section: Introductionmentioning

confidence: 99%

Hemoglobin, Albumin, Lymphocyte, and Platelet Score is Associated With Adverse Clinical Outcomes of Acute Ischemic Stroke: A Prospective Cohort Study

Tian

Wang

et al. 2020

Preprint

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Background The combined index of hemoglobin, albumin, lymphocyte and platelet (HALP) is considered as a novel score to reflect systemic inflammation and nutritional status. This study aimed to investigate the association between HALP score and adverse clinical events in patients with acute ischemic stroke (AIS). Methods This study prospectively included patients with AIS within 24 hours of admission to the First Affiliated Hospital of Zhengzhou University. The primary outcomes were all-cause death within 90 days and 1 year. The secondary outcomes included stroke recurrence and combined vascular events. The association between HALP score and adverse clinical outcomes was analyzed using Cox proportional hazards. Results A total of 1337 patients were included. Patients in the highest tertile of HALP score had a lower risk of death within 90 days and 1 year (Hazard ratio: 0.20 and 0.30; 95% confidence intervals: 0.06–0.66 and 0.13–0.69, P for trend < 0.01 for all) compared with the lowest tertile after adjusting relevant confounding factors. Similar results were found for secondary outcomes. Subgroup analyses further confirmed these association. Adding HALP score to the conventional risk factors improved prediction of death in patients with AIS within 90 days and 1 year (net reclassification index, 38.63% and 38.68%; integrated discrimination improvement, 2.43% and 2.57%; P < 0.02 for all). Conclusions High HALP score levels were associated with decreased risk of adverse clinical outcomes within 90 days and 1 year after stroke onset, suggesting that HALP score may serve as a powerful indicator for AIS.

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The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Patients with Small Cell Lung Cancer Before First-Line Treatment with Etoposide and Progression-Free Survival

Cited by 42 publications

References 28 publications

Inflammation Scores as Prognostic Biomarkers in Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Inflammation Scores as Prognostic Biomarkers in Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

HALP Score and Albumin Levels in Men with Prostate Cancer and Benign Prostate Hyperplasia

Hemoglobin, Albumin, Lymphocyte, and Platelet Score is Associated With Adverse Clinical Outcomes of Acute Ischemic Stroke: A Prospective Cohort Study

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