Physical activity and associations with treatment-induced adverse effects among prostate cancer patients

Bøhn, Synne-Kristin Hoffart; Fosså, Sophie D.; Wisløff, Torbjørn; Thorsen, Lene

doi:10.1007/s00520-018-4389-5

Cited by 8 publications

(8 citation statements)

References 176 publications

(269 reference statements)

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“…urinary, bowel and hormonal toxicity) and fatigue as well as sleep quality was also demonstrated for acute symptoms in exploratory analyses. In addition, bowel symptoms and urinary function have been shown to negatively affect physical activity levels in men with prostate cancer [40,41]. The resulting sedentary lifestyle may lead to development or aggravation of other chronic comorbidities that may further impact quality of life.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise During Radiation Therapy on Physical Function and Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic Review and Meta-Analysis

Schumacher

Luo

Taaffe

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionmentioning

confidence: 99%

Effects of Exercise During Radiation Therapy on Physical Function and Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic Review and Meta-Analysis

Schumacher

Luo

Taaffe

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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“…Depression, no motivation, fears, lack of knowledge about PA and QoL and no awareness of exercise program were mentioned as psychological barriers. Environmental and social related barriers were employment situation, access to facilities, bad weather and lack of time [18][19][20][21][22][23]. However, these findings cannot be transferred to the needs and requirements of ACP, since cancer survivors and ACP differ significantly regarding their life circumstances.…”

Section: Introductionmentioning

confidence: 98%

Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients

et al. 2020

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Background: In order to counteract fatigue, physical activity (PA) is recommended for all stages of cancer. However, only few advanced cancer patients (ACP) are physically active. Quantitative data with high numbers of ACP reporting barriers to PA are missing. This study aimed to identify barriers to PA in ACP with tiredness/weakness and investigate their motivation towards it. Methods: Outpatients with metastatic cancer receiving cancer care at a German Cancer Center reporting moderate/severe tiredness/weakness during self-assessment (MIDOS II) were enrolled. We assessed Fatigue-(FACF-F) and Depression (PHQ8) Scores, demographics, cancer-specific parameters, motivation for PA, physical, psychological and social barriers. Results: 141 of 440 eligible patients (32.0%) with different diagnoses agreed to participate. Patients frequently reported "I feel weakened due to my tumor therapy" (n = 108; 76.6%), physical symptoms (tiredness, weakness, dyspnea, joint-problems, pain, nausea [n = 107; 75.9%]) and fatigue (n = 99; 70.2%) as barriers to PA. However, no significant group differences regarding these barriers were found between physically active and inactive patients. Social barriers were rarely chosen. Motivated patients were 5.6 times more likely to be physically active (p < 0.001), also motivation turned out to be the strongest predictor for a physically active behavior (β = 1.044; p = 0.005). Motivated attitude towards PA was predicted by fatigue (β = − 2.301; p = 0.008), clinically relevant depression (β = − 1.390, p = 0.039), knowledge about PA and quality of life (QoL) (β = 0.929; p = 0.002), PA before diagnosis (β = 0.688; p = 0.005 and Interest in exercise program (β = 0.635; p = 0.008). Conclusion: "I feel weakened due to my tumor therapy" is the most reported barrier to PA among both, physically and inactive patients. Motivation for PA is the strongest predictor of performing PA. Interest in PA, knowledge about PA/ QoL and PA before diagnosis are main predictors of a motivated attitude. Absence/presence of social barriers did not associate with motivation, fatigue and depression proved to be a negative predictor. Programs including information, motivational counseling and individualized training should be offered for ACP to overcome barriers and reduce fatigue.

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“…10 Conversely, increasing bowel symptoms have been associated with a reduced likelihood of being physically active (ie, exercising 2 or more times per week) following treatment. 11 Exercise has been shown to reduce treatment-related adverse effects such as loss of muscle and bone mass, fatigue, and decline in physical function associated with ADT in men with prostate cancer. [12][13][14][15] Moreover, pelvic floor training programs have been effective in reducing the duration of incontinence after radical prostatectomy.…”

Section: Introductionmentioning

confidence: 99%

Effect of Exercise Adjunct to Radiation and Androgen Deprivation Therapy on Patient-Reported Treatment Toxicity in Men With Prostate Cancer: A Secondary Analysis of 2 Randomized Controlled Trials

Schumacher

Galvão

Taaffe

et al. 2021

Practical Radiation Oncology

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Physical inactivity, in addition to clinical factors, has been associated with higher levels of late pelvic symptoms in patients with prostate cancer (PCa) after radiation therapy. The aim of this study was to investigate the effect of a structured multicomponent exercise program comprised of aerobic and resistance training as well as impact loading on the prevalence and severity of symptoms commonly resulting from androgen deprivation therapy (ADT) and pelvic radiation therapy. Methods and Materials: We performed a secondary analysis of pooled data from 2 randomized controlled trials that investigated the role of exercise on treatment-related side effects in patients with PCa receiving ADT. Patients were included in the analysis if they had undergone radiation therapy during the intervention in addition to ADT. Patient-reported quality of life and functional and symptom scales were assessed using the European Organization for Research and Treatment of Cancer QLQ-C30 and PR25 before and after 6 months of exercise or usual care (UC).

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Physical activity and associations with treatment-induced adverse effects among prostate cancer patients

Cited by 8 publications

References 176 publications

Effects of Exercise During Radiation Therapy on Physical Function and Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic Review and Meta-Analysis

Effects of Exercise During Radiation Therapy on Physical Function and Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic Review and Meta-Analysis

Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients

Effect of Exercise Adjunct to Radiation and Androgen Deprivation Therapy on Patient-Reported Treatment Toxicity in Men With Prostate Cancer: A Secondary Analysis of 2 Randomized Controlled Trials

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