Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa

Qiu, Zhi-Kun; Liu, Xu; Tang, Dan; Zhang, Zhe; Fan, Qinghong; Pan, Yunyun; Chen, Yingyu; Huang, Meiyan; Zhu, Tao; Wang, Yulu; Cheng, Xiaofang; Chen, Jisheng

doi:10.1016/j.biopha.2018.07.112

Cited by 3 publications

(2 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The involvement of the translocator protein 18 kDa (TSPO) is a biomarker of neuroinflammation in vivo [ 46 , 47 ]. The neuroprotective effect of PF on neurodegenerative diseases such as AD may be mediated by TSPO and its downstream neurosteroids [ 48 ]. PF is confirmed to inhibit TNF- α and IL-1 β and the activity of NLRP3 inflammasome to relieve inflammatory reaction [ 49 ].…”

Section: Protection Of Neuronsmentioning

confidence: 99%

Multiple Roles of Paeoniflorin in Alzheimer’s Disease

Meng

Chen

Deng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a geriatric disease with the morbidity and mortality continuing to grow, partly due to the aging of the world population. As one of the most common types of primary neurodegenerative dementia, it is mainly due to environmental, epigenetic, immunological, and genetic factors. Paeoniflorin (PF), the main component of paeony extract, plays a more and more important role in the prevention and treatment of AD, including regulating protein, anti-inflammation, antioxidation, and antiapoptosis, protecting glial cells, regulating neurotransmitters and related enzymes and receptors, and inhibiting or activating related signal pathways. This article summarizes the latest researches on the multiple effects and the mechanisms of PF in the treatment to cure AD, providing new insights and research basis for further clinical application of traditional Chinese medicine (TCM) in the treatment of AD.

show abstract

Section: Protection Of Neuronsmentioning

confidence: 99%

Multiple Roles of Paeoniflorin in Alzheimer’s Disease

Meng

Chen

Deng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The active components from these three herbs are not suitable for the quantitative study. Paeoniflorin (PF, Figure 1(a) ) is one main bioactive monoterpenoid glycoside in Radix Paeoniae Alba, which possesses antidepressive, anti-inflammatory, analgesic, sedative, and hypnotic, immunomodulatory activities [ 8 – 10 ]. Berberine hydrochloride (BBR, Figure 1(b) ) is one of the most abundant and bioactive alkaloids in Cortex Phellodendri Chinensis, which is proved to show antidiabetic, antibacterial, and antihypertensive activities [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats

Wang

Yuan

et al. 2020

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

Bushen Pills (BSPs), as a traditional Chinese medicine (TCM), is widely used in clinic to enrich Yang, nourish Yin, stem essence, and strengthen kidneys. Two chromatographic methods, liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), were applied to analyze the multiple active components of BSPs in dosage form for quality evaluation and in rat plasma for pharmacokinetics study, respectively. Three active constituents of BSPs, including paeoniflorin (PF), berberine hydrochloride (BBR), and schizandrin (SCH), were simultaneously determined by the established LC-MS method with electrospray ionization (ESI) in positive selected ion monitoring (SIM) mode at m/z 503.1, 336.0, and 455.2. The contents of PF, BBR, and SCH were (6.112 ± 0.166) mg/g, (335.1 ± 14.95) μg/g, and (5.867 ± 0.136) μg/g in BSPs. On this basis, PF and BBR were selected as targeted analytes for the pharmacokinetic study of BSPs in rats. Memantine hydrochloride was used as an internal standard (IS), and the plasma samples were processed by liquid-liquid extraction with ethyl acetate. All the analytes were separated on a C18 reversed phase column, eluted with a mobile phase consisting of acetonitrile-formic acid (0.01%) (25 : 75, v/v), and detected by ESI in the selected ion mode with multiple reaction monitoring (MRM). The target fragment ions were m/z 525.3 ⟶ 449.5 for PF, 336.2 ⟶ 320.2 for BBR, and 180.1 ⟶ 163.1 for IS. The linear ranges of PF and BBR were 5–500 ng/mL and 0.1–20 ng/mL with good linearity (r2 > 0.99). No obvious matrix effect was observed, and acceptable accuracy, precision, recovery, and stability were obtained. The proposed method has been successfully applied to the pharmacokinetic study of BSPs in rats after a single dose.

show abstract

Simultaneous determination of calycosin-7-O-β-D-glucoside, cinnamic acid, paeoniflorin and albiflorin in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study of Huangqi Guizhi Wuwu Decoction

Guan

Wang

Jia

et al. 2019

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa

Cited by 3 publications

References 64 publications

Multiple Roles of Paeoniflorin in Alzheimer’s Disease

Multiple Roles of Paeoniflorin in Alzheimer’s Disease

Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats

Simultaneous determination of calycosin-7-O-β-D-glucoside, cinnamic acid, paeoniflorin and albiflorin in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study of Huangqi Guizhi Wuwu Decoction

Contact Info

Product

Resources

About

Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa

Cited by 3 publications

References 64 publications

Multiple Roles of Paeoniflorin in Alzheimer’s Disease

Multiple Roles of Paeoniflorin in Alzheimer’s Disease

Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats

Simultaneous determination of calycosin-7-O-β-D-glucoside, cinnamic acid, paeoniflorin and albiflorin in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study of Huangqi Guizhi Wuwu Decoction

Contact Info

Product

Resources

About

Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa