Multiple Roles of Paeoniflorin in Alzheimer’s Disease

Abstract

Alzheimer’s disease (AD) is a geriatric disease with the morbidity and mortality continuing to grow, partly due to the aging of the world population. As one of the most common types of primary neurodegenerative dementia, it is mainly due to environmental, epigenetic, immunological, and genetic factors. Paeoniflorin (PF), the main component of paeony extract, plays a more and more important role in the prevention and treatment of AD, including regulating protein, anti-inflammation, antioxidation, and antiapoptosis, protecting glial cells, regulating neurotransmitters and related enzymes and receptors, and inhibiting or activating related signal pathways. This article summarizes the latest researches on the multiple effects and the mechanisms of PF in the treatment to cure AD, providing new insights and research basis for further clinical application of traditional Chinese medicine (TCM) in the treatment of AD.

Therapeutic Effects and Metabolic Spectrum of Traditional Chinese Medicine Hengqing II Prescription on Alzheimer’s Disease

“…Traditional Chinese medicine (TCM) is one of the most in uential alternative medicines in the world. Faced with the challenges of treating AD, TCM has gained importance in the prevention and treatment of AD, with a bright future [11][12][13][14]. To date, there is no theoretical basis for using TCM prescription to treat AD.…”