Prevalence of neurological complications associated with Zika virus in a brazilian metropolis

Brito, Kattiucy Gabrielle da Silva; Santos, Edarlan Barbosa dos; Lucas, Liliane dos Santos Maia; Orsini, Marco; Fiorelli, Rossano; Teixeira, Silmar; Ayres, Carla; Correia, Luan; Bastos, Víctor Hugo; Trajano, Eduardo Tavares Lima; Cardoso, Carlos Eduardo; Freitas, Marcos R. G. de; Catharino, Antônio Marcos da Silva

doi:10.4081/ni.2018.7638

Cited by 2 publications

(2 citation statements)

References 13 publications

(13 reference statements)

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“…During this review period, we included 17 case reports 46, 220– 235 , 22 case series 120, 236– 256 , seven case-control studies 4, 257– 262 , one ecological study 266 , one modelling study 265 and eight outbreak reports 201, 203, 206, 266– 270 that reported on ZIKV infection and GBS.…”

Section: Resultsmentioning

confidence: 99%

“…Traveller/non-traveller populations: In studies included in this update, we found additional evidence of GBS in both travellers and non-travellers with ZIKV infection. Ten publications report on 11 travellers 218, 220, 222– 224, 227, 229, 232– 234 , while 34 publications report GBS due to ZIKV in 402 non travellers 4, 44, 118, 219, 221, 225, 226, 228, 230, 231, 235– 237, 239– 247, 249, 251, 253– 260, 262, 263 .…”

Section: Resultsmentioning

confidence: 99%

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Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

et al. 2019

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Background: The Zika virus (ZIKV) caused a large outbreak in the Americas leading to the declaration of a Public Health Emergency of International Concern in February 2016. A causal relation between infection and adverse congenital outcomes such as microcephaly was declared by the World Health Organization (WHO) informed by a systematic review structured according to a framework of ten dimensions of causality, based on the work of Bradford Hill. Subsequently, the evidence has continued to accumulate, which we incorporate in regular updates of the original work, rendering it a living systematic review. Methods: We present an update of our living systematic review on the causal relation between ZIKV infection and adverse congenital outcomes and between ZIKV and GBS for four dimensions of causality: strength of association, dose-response, specificity, and consistency. We assess the evidence published between January 18, 2017 and July 1, 2019. Results: We found that the strength of association between ZIKV infection and adverse outcomes from case-control studies differs according to whether exposure to ZIKV is assessed in the mother (OR 3.8, 95% CI: 1.7-8.7, I2=19.8%) or the foetus/infant (OR 37.4, 95% CI: 11.0-127.1, I2=0%). In cohort studies, the risk of congenital abnormalities was 3.5 times higher after ZIKV infection (95% CI: 0.9-13.5, I2=0%). The strength of association between ZIKV infection and GBS was higher in studies that enrolled controls from hospital (OR: 55.8, 95% CI: 17.2-181.7, I2=0%) than in studies that enrolled controls at random from the same community or household (OR: 2.0, 95% CI: 0.8-5.4, I2=74.6%). In case-control studies, selection of controls from hospitals could have biased results. Conclusions: The conclusions that ZIKV infection causes adverse congenital outcomes and GBS are reinforced with the evidence published between January 18, 2017 and July 1, 2019.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

et al. 2019

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Occurrence and Environmental Risk Assessment of Contaminants of Emerging Concern in Brazilian Surface Waters

Oliveira,

Mansano,

Holanda

et al. 2024

Enviro Toxic and Chemistry

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We investigated the occurrence and the environmental risk of eight contaminants of emerging concern (CECs; acetaminophen, naproxen, diclofenac, methylparaben, 17β‐estradiol, sulfathiazole, sulfadimethoxine, and sulfamethazine) in three Brazilian water bodies, namely, the Monjolinho River Basin (São Paulo State), the Mogi Guaçu River (São Paulo State), and the Itapecuru River (Maranhão State) in three sampling campaigns. The CECs were only quantified in surface water samples collected at the Monjolinho River Basin. Acetaminophen, naproxen, and methylparaben were detected in the range of <200 to 575.9 ng L−1, <200 to 224.7 ng L−1, and <200 to 303.6 ng L−1, respectively. The detection frequencies of the three measured compounds were between 33% and 67%. The highest concentrations of CECs were associated with intense urbanization and untreated sewage discharge. Furthermore, CEC concentrations were significantly correlated with total organic carbon, electrical conductivity, and dissolved oxygen levels, suggesting that domestic pollution from urban areas is an important source in the distribution of CECs in the Monjolinho River Basin. The environmental risk assessment indicated a high risk for acetaminophen (risk quotient [RQ] values between 2.1 and 5.8), a medium risk for naproxen (RQs between 0.6 and 0.7), and a low risk for methylparaben (RQs < 0.1) to the freshwater biota of the Monjolinho River Basin. Our findings show potential threats of CECs in Brazilian water bodies, especially in vulnerable areas, and reinforce the need for improvements in environmental regulations to include monitoring and control of these compounds in aquatic systems. Environ Toxicol Chem 2024;00:1–12. © 2024 SETAC

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Prevalence of neurological complications associated with Zika virus in a brazilian metropolis

Cited by 2 publications

References 13 publications

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

Occurrence and Environmental Risk Assessment of Contaminants of Emerging Concern in Brazilian Surface Waters

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