Hepcidin, iron indices and bone mineral metabolism in non-dialysis chronic kidney disease

Min, Hyang Ki; Sung, Su Ah; Oh, Yun Kyu; Kim, Yeong Hoon; Chung, Wookyung; Park, Sue Kyung; Ahn, Curie; Lee, Sung Woo

doi:10.1093/ndt/gfy235

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…Moreover, there may be a crosslink between the markers of bone mineral metabolism and those of anemia. The KNOW-CKD showed that elevated serum phosphorus and iPTH are associated with an increase in hepcidin, while elevated vitamin D levels are associated with a decrease in serum hepcidin levels after adjustment [30]. High FGF23 was associated with anemia at baseline and development of anemia during follow-up [31], which is consistent with the observation from the CRIC cohort [32].…”

Section: Mineral Bone Disease Of Ckdsupporting

confidence: 77%

“…Candidate biomarkers of CKD outcomes are cystatin C [21], albuminuria [52], adiponectin [53][54][55][56][57][58], FGF23 [31,59], high density lipoprotein cholesterol [60], troponin T [61] (Fig. 4), hepcidin [26,30], Klotho [28,62], OPG [63], and various urinary markers [46,47,[64][65][66]. The main results of the biomarker studies are described in Table 5 [28,[53][54][55][56][57][58][59][60][61][62][63][64][65][66].…”

Section: Biomarker Discovery In Ckdmentioning

confidence: 99%

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The KNOW-CKD Study: What we have learned about chronic kidney diseases

Kang

et al. 2020

Kidney Res Clin Pract

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Chronic kidney disease (CKD) is a growing health burden worldwide, as well as in Korea [1]. The numbers of patients with CKD and end-stage renal disease (ESRD) are increasing rapidly [2,3]. Not only CKD is a significant factor in morbidity and mortality, but the medical expenses for management of CKD are increasing remarkably.In order to broaden knowledge regarding the risk factors for CKD progression and adverse outcomes, the KoreaN Cohort Study for Outcomes in Patients With

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Section: Mineral Bone Disease Of Ckdsupporting

confidence: 77%

Section: Biomarker Discovery In Ckdmentioning

confidence: 99%

The KNOW-CKD Study: What we have learned about chronic kidney diseases

Kang

et al. 2020

Kidney Res Clin Pract

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“…2 i). The correlation between TSAT and hepcidin is not very clear [ 59 , 60 ]; we examined this association and found that TSAT and hepcidin were positively correlated (Fig. 2 j).…”

Section: Resultsmentioning

confidence: 99%

Association between iron metabolism and non-alcoholic fatty liver disease: results from the National Health and Nutrition Examination Survey (NHANES 2017–2018) and a controlled animal study

2022

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Background Iron metabolism may be involved in the pathogenesis of the non-alcoholic fatty liver disease (NAFLD). The relationship between iron metabolism and NAFLD has not been clearly established. This study aimed to clarify the relationship between biomarkers of iron metabolism and NAFLD. Methods Based on the National Health and Nutrition Examination Survey (NHANES), restricted cubic spline models and multivariable logistic regression were used to examine the association between iron metabolism [serum iron (SI), serum ferritin (SF), transferrin saturation (TSAT), and soluble transferrin receptor (sTfR)] and the risk for NAFLD. In addition, stratified subgroup analysis was performed for the association between TSAT and NAFLD. Moreover, serum TSAT levels were determined in male mice with NAFLD. The expression of hepcidin and ferroportin, vital regulators of iron metabolism, were analyzed in the livers of mice by quantitative real-time PCR (qRT-PCR) and patients with NAFLD by microarray collected from the GEO data repository. Results Patients with NAFLD showed decreased SI, SF, and TSAT levels and increased STfR levels based on the NHANES. After adjusting for confounding factors, TSAT was significantly negatively correlated with NAFLD. Of note, the relationship between TSAT and NAFLD differed in the four subgroups of age, sex, race, and BMI (P for interaction < 0.05). Consistently, mice with NAFLD exhibited decreased serum TSAT levels. Decreased hepcidin and increased ferroportin gene expression were observed in the livers of patients and mice with NAFLD. Conclusion Serum TSAT levels and hepatic hepcidin expression were decreased in both patients and mice with NAFLD. Among multiple biomarkers of iron metabolism, lower TSAT levels were significantly associated with a higher risk of NAFLD in the U.S. general population. These findings might provide new ideas for the prediction, diagnosis, and mechanistic exploration of NAFLD.

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“…Min et al. pointed out that the increased hepcidin levels were closely related to reduced 25‐hydroxyvitamin D in chronic kidney disease (CKD), further causing CKD-related bone fracture ( 82 ). Clinical research on hepcidin in bone loss is still lacking.…”

Section: Hepatokines: From Liver To Bonementioning

confidence: 99%

The roles of hepatokine and osteokine in liver-bone crosstalk: Advance in basic and clinical aspects

et al. 2023

Front. Endocrinol.

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Both the liver and bone are important secretory organs in the endocrine system. By secreting organ factors (hepatokines), the liver regulates the activity of other organs. Similarly, bone-derived factors, osteokines, are created during bone metabolism and act in an endocrine manner. Generally, the dysregulation of hepatokines is frequently accompanied by changes in bone mass, and osteokines can also disrupt liver metabolism. The crosstalk between the liver and bone, particularly the function and mechanism of hepatokines and osteokines, has increasingly gained notoriety as a topic of interest in recent years. Here, based on preclinical and clinical evidence, we summarize the potential roles of hepatokines and osteokines in liver-bone interaction, discuss the current shortcomings and contradictions, and make recommendations for future research.

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Hepcidin, iron indices and bone mineral metabolism in non-dialysis chronic kidney disease

Abstract: Markers of bone mineral metabolism and iron status, including hepcidin, were closely correlated to each other. Potential mechanisms of the relationship warrant further studies.

Cited by 7 publications

References 42 publications

The KNOW-CKD Study: What we have learned about chronic kidney diseases

The KNOW-CKD Study: What we have learned about chronic kidney diseases

Association between iron metabolism and non-alcoholic fatty liver disease: results from the National Health and Nutrition Examination Survey (NHANES 2017–2018) and a controlled animal study

The roles of hepatokine and osteokine in liver-bone crosstalk: Advance in basic and clinical aspects

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