Associations of ESR1 and ESR2 gene polymorphisms with metabolic syndrome and its components in postmenopausal women

Kuźbicka, Karolina; Rachoń, Dominik; Woziwodzka, Anna; Rybicka, Magda; Bielawski, Krzysztof Piotr

doi:10.1016/j.maturitas.2018.06.017

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…Because of the importance of ERα in the pathogenesis of breast cancer, ESR1 gene has been targeted by many researchers. Previous studies have shown that the specific SNP of ESR1 gene is associated with the occurrence of serious diseases in women such as breast, endometrial and ovarian cancer [10][11][12], as well as type 2 diabetes mellitus [13], osteoporosis [14], and metabolic syndrome depressive disorders [15]. GWAS have revealed that many SNPs of ESR1 gene are linked with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Impact of ESR1 Polymorphisms on Risk of Breast Cancer in the Chinese Han Population

Yang

et al. 2021

Clinical Breast Cancer

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Section: Introductionmentioning

confidence: 99%

Impact of ESR1 Polymorphisms on Risk of Breast Cancer in the Chinese Han Population

Yang

et al. 2021

Clinical Breast Cancer

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“…The discrepancies observed in the test results can probably be explained by the different size of the groups studied, different inclusion criteria, differences in the ages of the patients, or the intensity and type of symptoms. Kuźbicka et al demonstrated the relationship of selected polymorphisms of the ESR1 gene (rs2234693, rs6902771, rs7774230) with the occurrence of metabolic syndrome in postmenopausal women 47 . The ESR1 gene polymorphisms (rs2234693, rs9340799, rs2077647) also play a role in the exposure of the fetus to estrogens 48 .…”

Section: Discussionmentioning

confidence: 99%

The influence of ESR1 polymorphisms on selected hormonal, metabolic and mineral balance markers in women with hyperandrogenism

Uzar

Bogacz

Sowińska-Przepiera

et al. 2022

Sci Rep

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Hyperandrogenism is the most common endocrine disorder in women, characterized by an imbalance in normal estrogen and androgen levels in the blood. Androgens influence bone mineral density, body mass composition, muscle mass, mental state, and the regulation of sexual function.. The aim of the study was to assess the effect of estrogen receptor α gene (ESR1) polymorphisms on selected markers of bone metabolism and hormonal parameters in women with hyperandrogenism. The study group included 80 young women with hyperandrogenism who underwent measurements of bone mineral density (BMD), and determination of hormonal and metabolic parameters. Enzyme immunoassays were used to measure leptin, sRANKL (soluble receptor activator of nuclear factor-kB ligand), osteoprotegerin and 25-OH vitamin D total levels. An analysis of ESR1 gene polymorphisms was performed using the real-time PCR method. A relationship was demonstrated between the concentration of free estradiol (FEI) and the concentration of 17-OH-progesterone, and the ESR1 gene polymorphisms: rs3020314 (p = 0.031, p = 0.026 respectively) and rs1884051 (p = 0.033, p = 0.026 respectively). In conclusion, the ESR gene polymorphisms may be associated with hormonal disturbances in the concentration of estrogens and androgens, in hyperandrogenism in young women which may indirectly affect bone mineral density. However, no statistically significant relationships between the studied polymorphisms and the selected parameters of mineral metabolism have been demonstrated..

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“…The accordance rate (four matched targets of 61 predicted targets) was higher than the chance level ( p -value < 0.001, hypergeometric test), supporting the reliability of the predicted results. The ESR1 and ESR2 , which are involved in the estrogen signaling pathway, are highly related to menopause-related metabolic diseases [42]. A previous study has shown that ESR1 and NOS3 predict postmenopausal CVD-related endothelial responses and can be used to predict insulin resistance and type 2 diabetes risk [43].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Systems-Level Effect of Pueraria lobata for Menopause-Related Metabolic Diseases Using an Ovariectomized Rat Model and Network Pharmacological Analysis

Baek

Lee

et al. 2019

Biomolecules

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This study was conducted to evaluate the biological activities of Pueraria lobata (PL) on menopause-related metabolic diseases and to explore the underlying mechanism of PL by network pharmacological analyses. We used ovariectomized (OVX) rats as a postmenopausal model and administered PL at different doses (50, 100, and 200 mg/kg). In OVX rats, decreased uterine weights and PPAR-γ (peroxisome proliferator-activated receptor-gamma) mRNA expression in the thigh muscle were significantly recovered after PL administration. PL also significantly alleviated OVX-induced increases in total cholesterol, triglyceride, alanine aminotransferase (ALT/GPT), and aspartate aminotransferase (AST/GOT) levels. To identify the systems-level mechanism of PL, we performed network pharmacological analyses by predicting the targets of the potential bioactive compounds and their associated pathways. We identified 61 targets from four potential active compounds of PL: formononetin, beta-sitosterol, 3’-methoxydaidzein, and daidzein-4,7-diglucoside. Pathway enrichment analysis revealed that among female sex hormone-related pathways, the estrogen signaling pathways, progesterone-mediated oocyte maturation, oxytocin signaling pathways, and prolactin signaling pathways were associated with multiple targets of PL. In conclusion, we found that PL improved various indicators associated with lipid metabolism in the postmenopausal animal model, and we also identified that its therapeutic effects are exerted via multiple female sex hormone-related pathways.

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Associations of ESR1 and ESR2 gene polymorphisms with metabolic syndrome and its components in postmenopausal women

Cited by 10 publications

References 30 publications

Impact of ESR1 Polymorphisms on Risk of Breast Cancer in the Chinese Han Population

Impact of ESR1 Polymorphisms on Risk of Breast Cancer in the Chinese Han Population

The influence of ESR1 polymorphisms on selected hormonal, metabolic and mineral balance markers in women with hyperandrogenism

Investigating the Systems-Level Effect of Pueraria lobata for Menopause-Related Metabolic Diseases Using an Ovariectomized Rat Model and Network Pharmacological Analysis

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