Preparation and Characterization of Tetrahydrocurcumin-Loaded Cellulose Acetate Phthalate/Polyethylene Glycol Electrospun Nanofibers

Abstract

A simple composite electrospun nanofiber of cellulose acetate phthalate (CAP)-polyethylene glycol (PEG) loaded with tetrahydrocurcumin (THC) was developed in this study, and the in vitro diffusion of THC was evaluated. The nanofibers were characterized by scanning electron microscopy, powder X-ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC). The formulated nanofiber (NF) with THC has smooth morphology with diameter of around 300-500 nm. The complete entrapment and dispersion of THC was observed from the results of PXRD and DSC due to the loss of THC crystalline property. Further, FT-IR demonstrated that the vibration bands for the polymers used were dominant over the THC, and the vibrational bands of THC were not observed from the final formulation. The drug entrapment by the final CAP + PEG NF was found to be 95.5% with the high swelling index. From the in vitro release study, it was found that the formulated THC-loaded CAP + PEG NF has followed anomalous mechanism, demonstrating both diffusion and swelling controlled modes. The drug release extended up to 12 h with a final cumulative release of 94.24%.

3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System

“…The peak around 70°, related to the triple helix structure of collagen, represents the lateral packing distance between collagen chains [ 50 ] and the broad peak around 20°, associated with the diffuse scattering of collagen fibers, represents the amorphous structure of the samples [ 51 ]. Furthermore, the samples with THC showed the characteristic peaks of THC at 18° and 24° [ 15 ]. As can be seen, all samples showed similar XRD patterns, indicating the prevalence of the collagen structural order.…”

“…Concerning additive incorporation, thetrahydrocurcumin (THC) can be incorporated into printable collagen formulations to obtain active hydrogels for wound healing. THC is a plant-derived compound obtained from the hydrogenation of curcumin that has attracted special interest in the pharmaceutical and cosmetic industries [ 15 , 16 ]. Due to the poor solubility in water, low absorption from the gut, rapid metabolism, and rapid systemic elimination of curcumin, its health benefits are limited [ 17 ].…”

Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced diabetes mellitus

“…But it has poor efficacy, due to incomplete release at the site of absorption, short gastric emptying time, poor aqueous solubility, and primary excretion via the non-renal route ( Lai et al, 2020 , Setthacheewakul et al, 2011 ). In a study, the in vitro release of THC was found to be 94.24% from the electrospun nanofibers and its transdermal diffusivity confirms its suitability for wound healing or other skin ailments ( Rramaswamy et al, 2018 ). Solid lipid nanoparticles (SLNs) with 10–1000 nm particle size are spherical in shape and have multiple advantages over the other nanoformulations ( Kumar et al, 2022a ).…”

Characterizations on a GRAS Electrospun Lipid–Polymer Composite Loaded with Tetrahydrocurcumin

“…However, few studies have been carried out on TC with this technique. Cellulose acetate phthalate and polyethylene glycol were once utilized for electrospinning encapsulation of TC, with successful in vitro release [ 17 ]. Curcumin-encapsulated electrospun materials have apparently been more researched.…”