Dietary organic selenium addition and accumulation of toxic and essential trace elements in liver and meat of growing rabbits

Papadomichelakis, George; Zoidis, Evangelos; Pappas, Athanasıos C.; Danezis, George; Georgiou, Constantınos A.; Fegeros, K.

doi:10.1016/j.meatsci.2018.07.022

Cited by 11 publications

(6 citation statements)

References 33 publications

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“…Papadomichelakis et al (2018) reported reduced contents of As, Cr, Ni and Cd in the liver, and also observed that As and Cd decreased in the muscle of rabbits fed Se supplemented diets. The dietary addition of Se compounds has been proven an efficient therapy against heavy metal toxicity in mammals (Glynn et al, 1993), vegetables (Shanker et al, 1996), poultry (Pappas et al, 2011) and fish (Paulsson and Lundbergh, 1989). The current EU regulation limits the addition of organic Se to 0.2 mg/kg diet in all farm animals, so as not to exceed 0.5 mg of total Se/kg diet (EU, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Metallothioneins are low molecular weight cysteine-rich, intracellular proteins that bind metal ions for storage and/or for detoxification (Shen et al, 2013). Selenium forms biologically inactive complexes with As (Levander, 1977), Cd (Ohta et al, 1995) and Pb (Othman and El Missiry, 1998), which are excreted through bile, thus preventing accumulation in the body tissues of several animals (Glynn et al, 1993;Pappas et al, 2011;Paulsson and Lundbergh, 1989). Additionally, Se may participate in chelating Ni to proteins (Käkelä et al, 1999) and may have antagonistic interactions with Cr (Soudani et al, 2011), which likely explains the decrease in Ni and Cr concentrations, as well as the negative correlations between Se and Cr, and Ni in both rabbit tissues.…”

Section: Discussionmentioning

confidence: 99%

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Blood and hair as non-invasive trace element biological indicators in growing rabbits

et al. 2019

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The suitability of blood and hair as non-invasive tools to monitor trace element contents was studied in 48 Hyla male growing rabbits. Three diets with increasing organic selenium (Se) addition (0.1, 0.5 and 2.5 mg/kg) were used to induce alterations in the concentrations of trace elements vs. an unsupplemented diet. In blood, a linear decrease in Co (P<0.001), Cu (P<0.001), Mn (P<0.05), Zn (P<0.05), Sb (P<0.001), As (P<0.001), Cr (P<0.001), Mo (P<0.001), Ni (P<0.001) and Cd (P<0.001) concentrations with increasing dietary Se was observed. In hair, a cubic effect of dietary Se on Co (P<0.01), Cu (P<0.05), Mn (P<0.001), Pb (P<0.05), Mo (P<0.05) and Cd (P<0.05) concentrations was found, while As, Cr and Ni concentrations decreased linearly (P<0.01, P<0.01 and P<0.001, respectively) with increasing dietary Se. Selenium was negatively correlated to Sb, As, Cr, Mo, Ni and Cd, (P<0.001) in blood, and to As (P<0.05), Cr, Ni (P<0.01) and Pb (P<0.05) in hair. The contents of Se, As, Cr and Ni in blood were highly correlated (P<0.001) to those in hair. Blood appeared to be more sensitive than hair in detecting small changes in the trace element profile in rabbits, as was indicated by the discriminant analysis. In conclusion, blood and hair can be suitable biological indicators of essential, toxic and potentially toxic trace element status in rabbits, particularly when used complementarily.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Blood and hair as non-invasive trace element biological indicators in growing rabbits

et al. 2019

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“…Dietary Se supplementation increased Se concentration linearly from to 2-to 4-fold in rabbits' meat (Dokoupilová et al, 2007;Ebeid et al, 2013;Matics et al, 2017;Papadomichelakis et al, 2018;Amer et al, 2019;Minardi et al 2020). Moreover, Papadomichelakis et al (2017) indicated that total PUFA concentration was increased linearly leading to a linear increase in PUFA:SFA ratio with dietary Se increment.…”

Section: Seleniummentioning

confidence: 94%

Current Prospects of Nutraceuticals in Rabbit Productivity and Health – an Updated Review

Ebeid,

Al-Homidan,

Aljabeili

et al. 2024

Annals of Animal Science

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Weaned rabbits become extremely vulnerable to enteric infections as a result of ban of using antibiotics as growth promoters. Recently, there are a growing interest in natural alternatives of antibiotics that could be used in rabbit production. Nutraceuticals are dietary components that offer additional health benefits override their nutritive benefits. Nutraceuticals include vitamins, minerals, antioxidants, probiotics, prebiotics, synbiotics, enzymes, organic acids, fatty acids, medicinal plants, etc. Due to its potential impacts on maintaining the normal physiological status, strengthening the immune system, and preventing illness, which ultimately led to an increase in productivity, nutraceuticals have recently attracted a lot of attention in rabbit farms. The objective of the present review is to provide information on recent findings about the advantages of dietary supplementation of nutraceuticals on performance, digestibility, meat quality, antioxidative properties, and immunological response in rabbits.

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“…Selenium toxicity in foods depends on its chemical forms. Generally, organic selenium is less toxic than the inorganic selenium [5,6].…”

Section: Introductionmentioning

confidence: 99%

The protective effects of vitamin E against selenium-induced oxidative damage and hepatotoxicity in rats

Alahmadi

El-Alfy

Hemaid

et al. 2020

Journal of Taibah University for Science

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Selenium is a trace element which can be toxic when consumed at high levels. The study was conducted to assess the possible protective role of vitamin E against selenosis in rats. Selenium was applied at different single doses (4.5, 9 and 18 mg/kg b.wt.). Vitamin E (200 mg/kg b.wt.) was given to the rats one hour before treatment with the higher selenium dose. In seleniumtreated rats, selenosis was evident from the elevated level of malondialdehyde. Oxidative stress was induced from the significant altered activity levels of CAT, SOD and GPx. Furthermore, selenium-induced hepatotoxicity was developed, where the activity levels of AST, ALT and GGT were significantly increased. Hepatotoxicity was also manifested histologically. Pretreatment with vitamin E significantly alleviated the affected levels of the investigated parameters, and counteracted the hepatic histopathological changes. The results demonstrate that vitamin E supplementation provides an effective protection against oxidative damage and hepatotoxicity induced by selenosis.

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Dietary organic selenium addition and accumulation of toxic and essential trace elements in liver and meat of growing rabbits

Cited by 11 publications

References 33 publications

Blood and hair as non-invasive trace element biological indicators in growing rabbits

Blood and hair as non-invasive trace element biological indicators in growing rabbits

Current Prospects of Nutraceuticals in Rabbit Productivity and Health – an Updated Review

The protective effects of vitamin E against selenium-induced oxidative damage and hepatotoxicity in rats

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