Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation

Zhou, Xueyan; Zhao, Yun; Wang, Juan; Xi, Wang; Chen, Chunxia; Yin, Di; Zhao, Feng; Yin, Jie; Guo, Meng; Zhang, Longzhen; Du, Lei; Zhang, Bei; Yin, Xiaoxing

doi:10.1016/j.bcp.2018.07.006

Cited by 42 publications

(31 citation statements)

References 52 publications

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“…Highly selective substrates and selective inhibitors of UGTs have been found in natural products and from other sources. Resveratrol can activate UGT1A8 expression, and is used for breast cancer treatment 47 . Different doses of emodin can inhibit the activity of UGT2B7 48 .…”

Section: Determinants Of Pkmentioning

confidence: 99%

Current trends in drug metabolism and pharmacokinetics

Meng

Yang

et al. 2019

Acta Pharmaceutica Sinica B

188

124

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Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication. In this review we provided an overview of recent research on PK with focus on the following aspects: (1) an update on drug-metabolizing enzymes and transporters in the determination of PK, as well as advances in xenobiotic receptors and noncoding RNAs (ncRNAs) in the modulation of PK, providing new understanding of the transcriptional and posttranscriptional regulatory mechanisms that result in inter-individual variations in pharmacotherapy; (2) current status and trends in assessing drug–drug interactions, especially interactions between drugs and herbs, between drugs and therapeutic biologics, and microbiota-mediated interactions; (3) advances in understanding the effects of diseases on PK, particularly changes in metabolizing enzymes and transporters with disease progression; (4) trends in mathematical modeling including physiologically-based PK modeling and novel animal models such as CRISPR/Cas9-based animal models for DMPK studies; (5) emerging non-classical xenobiotic metabolic pathways and the involvement of novel metabolic enzymes, especially non-P450s. Existing challenges and perspectives on future directions are discussed, and may stimulate the development of new research models, technologies, and strategies towards the development of better drugs and improved clinical practice.

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Section: Determinants Of Pkmentioning

confidence: 99%

Current trends in drug metabolism and pharmacokinetics

Meng

Yang

et al. 2019

Acta Pharmaceutica Sinica B

188

124

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“…UDP-glycosyltransferase catalyzes the transfer of glycosyl groups from activated donor molecules to receptor molecules and participates in several activities, such as detoxification, defense response, and regulation of hormone levels [40]. Glutathione S-transferase reduces cellular oxidative stress.…”

Section: Resveratrol Protects Sugar and Lipid Damage To Nematodesmentioning

confidence: 99%

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

Wang

Zhang

et al. 2020

Genes Nutr

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Background: Excessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and complications. Here, we characterized the effects of different types of sugar and lipids on the growth and development of Caenorhabditis elegans. Methods: We measured the lifespan, reproductive capacity, and length of nematodes after sugars and lipids treatment alone and co-treatment of sugars and lipids. Furthermore, we studied the mechanisms underlying the damage caused by high-sucrose and high-stearic acid on C.elegans by using transcriptome sequencing technology. Results: The results showed that a certain concentration of sugar and lipid promoted the growth and development of nematodes. However, excessive sugars and lipids shortened the lifespan and length of nematodes and destroyed their reproductive capacity. Based on the results of the orthogonal test, we selected 400 mmol/L sucrose and 500 μg/mL stearic acid to model a high-sugar and high-lipid diet for C. elegans. Conclusion: High-sugar and high-lipid intake altered the expression of genes involved in biofilm synthesis, genes that catalyze the synthesis and degradation of endogenous substances, and genes involved in innate immunity, resulting in physiological damage. Furthermore, we explored the protective effect of resveratrol on high-sugar and high-lipid damage to nematodes. Resveratrol plays a role in repairing by participating in the metabolism of foreign substances and reducing cellular oxidative stress.

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“…UDP-glycosyltransferase catalyzes the transfer of glycosyl groups from activated donor molecules to receptor molecules, and participates in several activities, such as detoxification, defense response, and regulation of hormone levels (Z hou et al . 2018).…”

Section: Discussionmentioning

confidence: 99%

Effects of sugars and lipids on the growth and development ofCaenorhabditis elegans

Xiong

Lin

Zhang

et al. 2019

Preprint

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18Excessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and 19 complications. Here, we characterized the effects of different types of sugar and lipids on the 20 growth and development of Caenorhabditis elegans. We measured the lifespan, reproductive 21 capacity, and length of nematodes after sugars and lipids treatment alone and co-treatment of sugars 22 and lipids. Furthermore, by using transcriptome sequencing technology, we studied the mechanisms 23 underlying the damaged caused by high-sucrose and high-stearic acid on C. elegans. The results 24 showed that a certain concentration of sugar and lipid promoted the growth and development of 25 nematodes. However, excessive sugars and lipids shortened the lifespan and length of nematodes 26 and destroyed their reproductive capacity. Based on the results of the orthogonal test, we selected 27 400 mmol/L sucrose and 500 μg/mL stearic acid to model a high-sugar and high-lipid diet for C. 28 elegans. High-sugar and high-lipid intake altered the expression of genes involved in biofilm 29 synthesis, genes that catalyze the synthesis and degradation of endogenous substances, and genes 30 involved in innate immunity, resulting in physiological damage. 31 Introduction 32 All animals require energy to sustain basic life activities, such as survival, growth, and 33 reproduction. Digested and absorbed, dietary nutrients are important precursors for the synthesis 34 and metabolism of cells. Carbohydrates and fats are the main organic material sources to sustain life 35 activities. Carbohydrates are present in all living organisms and have a variety of basic functions, 36providing energy for all non-photosynthetic organisms. Lipids perform many essential functions in 37 cells. Due to their highly reduced state, they are effective energy storage molecules. They are 38 bilayered hydrophobic units that form cells and organelle membranes, and act as effective signaling 39 molecules to facilitate communication between cells (SATOUCHI et al. 1993). Reasonable 40 2 carbohydrate and fat intake has a positive impact on human life activities, but excessive intake may 41 be harmful to the human body, leading to diabetes, high blood pressure, and tumors. In recent years, 42 with the prevalence of human obesity and diabetes, interest in lipid and carbohydrate metabolism 43 has become increasingly prominent. 44With the improvement in people's living standards, the dietary structure has gradually developed 45 towards high sugar and high lipid. Continued high sugar and high lipid intake can lead to several 46 abnormal conditions, such as obesity and type 2 diabetes. High fat and high lipid intake lead to 47 over-nutrition, which, in turn, causes obesity. In the past 40 years, the world's obese population has 48 increased from 105 million in 1975 to 641 million in 2014. Almost one in every 8 adults in the 49 world has obesity problems; China is a country with the greatest number of obese people (ASHRAFI 50 2007). Obesity increases the risk ...

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Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation

Cited by 42 publications

References 52 publications

Current trends in drug metabolism and pharmacokinetics

Current trends in drug metabolism and pharmacokinetics

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

Effects of sugars and lipids on the growth and development ofCaenorhabditis elegans

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