30-Day Oral Toxicity Study of L-Selenomethionine in Female Long-Tailed Macaques (<i>Macaca fascicularis</i>)

Cukierski, Mark A.; Willhite, Calvin C.; Lasley, Bill L.; Hendrie, Tammy A.; Book, Steven A.; Cox, Douglas N.; Hendrickx, Andrew G.

doi:10.1093/toxsci/13.1.26

Cited by 6 publications

(4 citation statements)

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“…In nature, selenomethionine (Se-Met) is found almost exclusively in the l-form, the other stereoisomer is the d-form (Cukierski et al 1989). dl-selenomethionine is a racemic mixture of Se-Met in which the d and l stereoisomers are present in equal amounts when Se-Met is manufactured in the laboratory (Maier et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Comparison of different forms of dietary selenium supplementation on gene expression of cytoplasmic thioredoxin reductase, selenoprotein P, and selenoprotein W in broilers

Zhan¹,

Wang²,

Yuan³

et al. 2014

Czech J. Anim. Sci.

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ABSTRACT:Effects of different forms of dietary selenium (Se) supplementation on gene expression of cytoplasmic thioredoxin reductase (TrxR1), selenoprotein P (SelP), and selenoprotein W (SelW) in broilers were investigated. A total of six hundred Ross 308 broilers (1-day-old) with similar body weight were randomly divided into three groups, each of which included 5 replicates of 40 birds. These three treatments received the same basal diet with only background Se level of 0.04 mg Se/kg, supplemented with 0.15 mg Se/kg as sodium selenite (SS) or l-selenomethionine (l-Se-Met) or d-selenomethionine (d-Se-Met) for 42 days. The SS supplemented diet increased TrxR1 activity in liver (P < 0.01) and kidney (P < 0.01) as well as SelP concentration in serum (P < 0.05) and liver (P < 0.01) more than the d-Se-Met supplemented diet. The addition of SS also highly increased liver (P < 0.01) and kidney (P < 0.01) TrxR1 activities of broilers in comparison with broilers fed l-Se-Met diet. In addition, liver TrxR1 activity in l-Se-Met group was higher than that in d-Se-Met group (P < 0.05). Liver and kidney mRNA levels of TrxR1 and SelP as well as breast muscle SelW mRNA level were significantly increased by l-and d-Se-Met supplementation in comparison with SS supplementation (P < 0.01), while the d-Se-Met group showed more effective (P < 0.01) than the l-Se-Met group in increasing the mRNA levels of TrxR1 and SelP in liver and kidney. Therefore, dietary l-Se-Met and d-Se-Met supplementation could improve mRNA levels of different selenoproteins studied and reduce amounts of TrxR1 and SelP in broilers compared with SS. Besides, l-Se-Met is more effective than d-Se-Met in raising TrxR1 activity and decreasing mRNA abundance of TrxR1 and SelP in broilers.

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Section: Introductionmentioning

confidence: 99%

Comparison of different forms of dietary selenium supplementation on gene expression of cytoplasmic thioredoxin reductase, selenoprotein P, and selenoprotein W in broilers

Zhan¹,

Wang²,

Yuan³

et al. 2014

Czech J. Anim. Sci.

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“…However, the US Agency for Toxic Substances and Disease Registry lists a number of comparable kidney effects in animals following exposure to selenium at levels several hundred times higher than normal human intake [ 38 ]. Effects include hydropic degeneration in sheep [ 61 ], increases in kidney weights in mice and ducks [ 62 - 64 ], larger Bowman's capsules and minimal papilla degeneration of the kidneys in rats [ 62 , 65 ], and glomerulonephritis and proximal convoluted tubule nephropathy in long-tailed macaques [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Metals and kidney markers in adult offspring of endemic nephropathy patients and controls: a two-year follow-up study

Karmaus

Dimitrov

Simeonov³

et al. 2008

Environ Health

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Background: The etiology of Balkan Endemic Nephropathy, (BEN), a tubulointerstitial kidney disease, is unknown. Although this disease is endemic in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, similar manifestations are reported to occur in other regions, for instance Tunisia and Sri Lanka. A number of explanations have been stated including lignites, aristolochic acid, ochratoxin A, metals, and metalloids. Etiologic claims are often based on one or a few studies without sound scientific evidence. In this systematic study, we tested whether exposures to metals (cadmium and lead) and metalloids (arsenic and selenium) are related to Balkan Endemic Nephropathy.

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“…In nature, SM is found almost exclusively in the L form [18], which is one of the two stereoisomer forms it can take, and is reported the active form in animal metabolism process; the other stereoisomer is the D form, which is concluded to function in animal metabolism process once converted to L-SM. It was reported that both D-and L-methionine and phenylalanine enantiomorphism were regarded as essentially equivalent for growth purpose [19,20].…”

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Effect of Different Selemethionine Forms and Levels on Performance of Breeder Hens and Se Distribution of Tissue and Egg Inclusion

Zhan

Wang

et al. 2010

Biol Trace Elem Res

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A 2×2 factorial arrangement of treatments in randomized design was conducted to investigate the effect of different selenomethionine (SM) sources and levels on the productive performance of breeder hens and the Se distribution in the inclusion of eggs and serum and tissues of breeder hens and its offspring. A total of 480 Ling-Nan-Huang breeder hens, 48 weeks of age, were allocated to four treatments, each of which included three replicates of 40 hens. Pretreatment period was 2 weeks, and the experiment lasted 8 weeks. Two SM forms of DL-SM and L-SM were supplemented at 0.15 or 0.30 mg Se/kg into the basal diet. Results showed that the Se level of 0.15 mg/kg supplemented in the diet, compared to 0.30 mg/kg, significantly elevated the percentage of egg production (p<0.05), hatchability (p<0.01), and birthrate (p<0.01), whereas the Se level of 0.30 mg/kg led to a higher Se content in egg contents, serum, and all tissues (p<0.01). In addition, the form of DL-SM showed a significant increase in Se content of egg inclusion (p<0.01), serum (p<0.01), and all tissues (p<0.01, except breeder hens' pancreas and its offspring's liver and breast muscle). The birthrate and yolk Se content were markedly influenced by the interaction between Se source and Se level (p<0.01). The above results suggested that DL-SM, compared to L-SM, had a similar equal effect on the performance of breeder hens, but DL-SM was superior to L-SM with respect to selenium distribution in egg inclusion, serum, and tissues.

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30-Day Oral Toxicity Study of L-Selenomethionine in Female Long-Tailed Macaques (Macaca fascicularis)

Cited by 6 publications

References 0 publications

Comparison of different forms of dietary selenium supplementation on gene expression of cytoplasmic thioredoxin reductase, selenoprotein P, and selenoprotein W in broilers

Comparison of different forms of dietary selenium supplementation on gene expression of cytoplasmic thioredoxin reductase, selenoprotein P, and selenoprotein W in broilers

Metals and kidney markers in adult offspring of endemic nephropathy patients and controls: a two-year follow-up study

Effect of Different Selemethionine Forms and Levels on Performance of Breeder Hens and Se Distribution of Tissue and Egg Inclusion

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