3 Tesla <sup>1</sup>H MR spectroscopy of hip bone marrow in a healthy population, assessment of normal fat content values and influence of age and sex

Pansini, Vittorio; Monnet, Aurélien; Salleron, Julia; Hardouin, Pierre; Cortet, Bernard; Cotten, Anne

doi:10.1002/jmri.24176

Cited by 48 publications

(36 citation statements)

References 43 publications

(57 reference statements)

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“…This is somewhat surprising given the reported associations between BMAT and these variables in other cohorts. (13,14) However, in the AGES-Reykjavik cohort these associations were only modest, perhaps as a result of the advanced age and relatively narrow age range of this cohort.…”

Section: Discussionmentioning

confidence: 82%

Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity

Woods

Ewing

Sigurðsson

et al. 2018

Journal of Bone and Mineral Research

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Bone marrow adiposity is associated with aging, osteoporosis, and reduced hematopoiesis, as well as anorexia nervosa, but little is known about the underlying mechanisms that affect marrow adiposity. Chronic kidney disease (CKD) may influence bone marrow adipose tissue (BMAT), possibly through loss of lean mass or higher circulating levels of sclerostin. To test these hypotheses, we investigated the cross-sectional association between estimated glomerular filtration rate (eGFR) as a measure of kidney function and H-MRS-based measurement of vertebral BMAT (L1 to L4) in 475 older adults from the Age Gene/Environment Susceptibility (AGES)-Reykjavik study. Mean BMAT was compared in those with eGFR>60 (n = 297) versus those with eGFR 45 to 60 (n = 120) or eGFR <45 (n = 58) using linear regression models. Participants had a mean age of 81.5 (SD 4.1) years, mean eGFR of 64.3 (SD 16.1) mL/min/1.734 cm , mean BMAT of 54.5% (SD 8.5); 48.2% were women. In unadjusted and adjusted models (age, visit window, gender, diabetes and visceral adipose tissue), BMAT was higher in those with eGFR <45 (adjusted mean 58.5%; 95% CI, 56.2 to 60.7) compared with those with eGFR >60 (adjusted mean 53.8%; 95% CI, 52.8 to 54.8) (p = 0.0002). BMAT did not differ in those with eGFR 45 to 60 (adjusted mean 54.3%; 95% CI, 52.8 to 55.9) compared with those with eGFR >60 (p = 0.58). In a subgroup of participants with serum sclerostin available (n = 253), additional adjustment for sclerostin attenuated the difference in adjusted mean vertebral BMAT between those with eGFR <45 versus >60 from 3.7% (p = 0.04) to 2.4% (p = 0.20). CKD stage 3b or worse was associated with greater bone marrow adiposity; this association may be partially mediated by sclerostin. © 2018 American Society for Bone and Mineral Research.

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Section: Discussionmentioning

confidence: 82%

Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity

Woods

Ewing

Sigurðsson

et al. 2018

Journal of Bone and Mineral Research

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“…MRS‐based vertebral bone marrow fat fraction has been also recently shown to be in good agreement with the bone marrow fat fraction from dual‐energy computed tomography (CT) . Finally, good reproducibility values have been reported for both imaging‐based and MRS‐based bone marrow fat fraction in the spine and the proximal femur …”

Section: Technical Aspects Of Quantitative Bone Marrow Mri and Mrsmentioning

confidence: 75%

Quantitative MRI and spectroscopy of bone marrow

Karampinos

Ruschke

Dieckmeyer

et al. 2017

Magnetic Resonance Imaging

202

241

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Bone marrow is one of the largest organs in the human body, enclosing adipocytes, hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal stem cells, which are responsible for the production of adipocytes and bone cells. Magnetic resonance imaging (MRI) is the ideal imaging modality to monitor bone marrow changes in healthy and pathological states, thanks to its inherent rich soft‐tissue contrast. Quantitative bone marrow MRI and magnetic resonance spectroscopy (MRS) techniques have been also developed in order to quantify changes in bone marrow water–fat composition, cellularity and perfusion in different pathologies, and to assist in understanding the role of bone marrow in the pathophysiology of systemic diseases (e.g. osteoporosis). The present review summarizes a large selection of studies published until March 2017 in proton‐based quantitative MRI and MRS of bone marrow. Some basic knowledge about bone marrow anatomy and physiology is first reviewed. The most important technical aspects of quantitative MR methods measuring bone marrow water–fat composition, fatty acid composition, perfusion, and diffusion are then described. Finally, previous MR studies are reviewed on the application of quantitative MR techniques in both healthy aging and diseased bone marrow affected by osteoporosis, fractures, metabolic diseases, multiple myeloma, and bone metastases. Level of Evidence: 3 Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:332–353.

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“…Our working model is that BMAT within rodent paws will be characterized as cBMAT, whereas that within radius and humerus will mainly be rBMAT. Whereas human adult males generally have more BMAT than premenopausal females 14, 15 , adult female mice appear to have more rBMAT in tibia than males 18, 21, 27 . In contrast, cBMAT in distal tibia is similar between sexes 18, 21, 27 .…”

Section: Development and Regulation Of Bmat In Humans And Rodentsmentioning

confidence: 87%

“…Although the general patterning of BMAT development in humans occurs similarly between males and females, the absolute amount of bone marrow fat within vertebrae, sacrum and hips of adult males is higher than in age-matched females 12, 14, 15 . It should be noted, however, that vertebral BMAT rises sharply in women between 55 and 65 years of age, and is associated with menopause.…”

Section: Development and Regulation Of Bmat In Humans And Rodentsmentioning

confidence: 96%

Development, regulation, metabolism and function of bone marrow adipose tissues

Hardij

Bagchi

et al. 2018

Bone

121

128

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Most adipocytes exist in discrete depots throughout the body, notably in well-defined white and brown adipose tissues. However, adipocytes also reside within specialized niches, of which the most abundant is within bone marrow. Whereas bone marrow adipose tissue (BMAT) shares many properties in common with white adipose tissue, the distinct functions of BMAT are reflected by its development, regulation, protein secretion, and lipid composition. In addition to its potential role as a local energy reservoir, BMAT also secretes proteins, including adiponectin, RANK ligand, dipeptidyl peptidase-4, and stem cell factor, which contribute to local marrow niche functions and which may also influence global metabolism. The characteristics of BMAT are also distinct depending on whether marrow adipocytes are contained within yellow or red marrow, as these can be thought of as 'constitutive' and 'regulated', respectively. The rBMAT for instance can be expanded or depleted by myriad factors, including age, nutrition, endocrine status and pharmaceuticals. Herein we review the site specificity, age-related development, regulation and metabolic characteristics of BMAT under various metabolic conditions, including the functional interactions with bone and hematopoietic cells.

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3 Tesla ¹H MR spectroscopy of hip bone marrow in a healthy population, assessment of normal fat content values and influence of age and sex

Abstract: We obtained normal spectroscopic FC values from different areas of the hip, according to age and sex. These values may be used as reference values to evaluate, by the means of (1) H MR spectroscopy, pathological conditions affecting hip bone marrow.

Cited by 48 publications

References 43 publications

Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity

Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity

Quantitative MRI and spectroscopy of bone marrow

Development, regulation, metabolism and function of bone marrow adipose tissues

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3 Tesla 1H MR spectroscopy of hip bone marrow in a healthy population, assessment of normal fat content values and influence of age and sex

Abstract: We obtained normal spectroscopic FC values from different areas of the hip, according to age and sex. These values may be used as reference values to evaluate, by the means of (1) H MR spectroscopy, pathological conditions affecting hip bone marrow.

Cited by 48 publications

References 43 publications

Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity

Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity

Quantitative MRI and spectroscopy of bone marrow

Development, regulation, metabolism and function of bone marrow adipose tissues

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Product

Resources

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3 Tesla ¹H MR spectroscopy of hip bone marrow in a healthy population, assessment of normal fat content values and influence of age and sex