3 Tesla 23Na Magnetic Resonance Imaging During Aerobic and Anaerobic Exercise

Hammon, Matthias; Grossmann, Susan; Linz, Peter; Kopp, Christoph W.; Dahlmann, Anke; Janka, Rolf; Cavallaro, Alexander; Uder, Michael; Titze, Jens

doi:10.1016/j.acra.2015.06.005

Cited by 25 publications

(37 citation statements)

References 33 publications

(70 reference statements)

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“…Additionally we measured significantly higher fat/water volume in the calf of lipedema patients, indicating both elevated intramuscular adipose tissue and reduced muscle size. While elevated sodium has also been observed throughout the muscle in the case of anaerobic exercise 21 , local muscle injuries 22 , or essential hypertension with increasing age 12 , 23 , lipedema is the first condition in which we have observed both increased muscle sodium and adipose content. This suggests that myopathy may be a clinical feature of lipedema that is consistent with the frequently reported symptom of chronic fatigue.…”

Section: Discussionsupporting

confidence: 50%

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Crescenzi

Marton

Donahue

et al. 2017

Obesity

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Objective To test the hypothesis that tissue sodium and adipose content are elevated in patients with lipedema; if confirmed, this could establish precedence for tissue sodium and adipose content representing a discriminatory biomarker for lipedema. Methods Participants with lipedema (n=10) and control (n=11) volunteers matched for biological sex, age, body-mass-index, and calf circumference were scanned noninvasively with 3.0T sodium and conventional proton MRI. Standardized tissue sodium content was quantified in skin, subcutaneous adipose tissue (SAT), and calf muscle. Dixon MRI was employed to quantify tissue fat and water volumes of the calf. Nonparametric statistical tests were applied to compare regional sodium content and fat-to-water volume ratio between groups (significance: two-sided p≤0.05). Results Skin (p=0.01) and SAT (p=0.04) sodium content were elevated in lipedema (skin: 14.9±2.9 mmol/L; SAT: 11.9±3.1 mmol/L) relative to control (skin: 11.9±2.0 mmol/L; SAT: 9.4±1.6 mmol/L) participants. Relative fat volume in the calf was elevated in lipedema (1.2±0.48 ratio) relative to control (0.63±0.26 ratio, p<0.001) participants. Skin sodium content was directly correlated with fat-to-water volume ratio (Spearman’s-rho=0.54, p=0.01). Conclusions Internal metrics of tissue sodium and adipose content are elevated in patients with lipedema potentially providing objective imaging-based biomarkers for differentially diagnosing the under-recognized condition of lipedema from obesity.

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Section: Discussionsupporting

confidence: 50%

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Crescenzi

Marton

Donahue

et al. 2017

Obesity

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“…They also compared the results of healthy volunteers to those who were diabetic, noting a similar increase in sodium intensity of 10-11%, but a longer recovery halflife of 27-37 minutes. Hammon et al recently performed a similar study at 3 Tesla in both the calf and triceps muscles, and found similar changes in sodium signal intensity and concentration post exercise as previous investigators (94).…”

Section: Muscle Response To Exercisesupporting

confidence: 63%

Quantitative sodium magnetic resonance imaging of cartilage, muscle, and tendon

Bangerter¹,

Tarbox²,

Taylor³

et al. 2016

Quant. Imaging Med. Surg.

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Sodium magnetic resonance imaging (MRI), or imaging of the 23Na nucleus, has been under exploration for several decades, and holds promise for potentially revealing additional biochemical information about the health of tissues that cannot currently be obtained from conventional hydrogen (or proton) MRI. This additional information could serve as an important complement to conventional MRI for many applications. However, despite these exciting possibilities, sodium MRI is not yet used routinely in clinical practice, and will likely remain strictly in the domain of exploratory research for the coming decade. This paper begins with a technical overview of sodium MRI, including the nuclear magnetic resonance (NMR) signal characteristics of the sodium nucleus, the challenges associated with sodium MRI, and the specialized pulse sequences, hardware, and reconstruction techniques required. Various applications of sodium MRI for quantitative analysis of the musculoskeletal system are then reviewed, including the non-invasive assessment of cartilage degeneration , imaging of tendinopathy, applications in the assessment of various muscular pathologies, and assessment of muscle response to exercise.

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“…We performed 23 Na- and 1 H-MR imaging with a 3 Tesla scanner (Magnetom Trio, Siemens Healthcare GmbH, Erlangen, Germany) of both lower legs. We used a customized 23 Na knee coil as described previously (Kopp et al 2013 , 2012a , b ; Hammon et al 2015a , b ). A gradient echo 23 Na sequence was applied (total acquisition time TA: 3.25 min, echo time TE: 2.07 ms, repetition time TR: 100 ms, flip angle FA: 90°, 32 averages, resolution: 3 × 3 × 30 mm 3 ).…”

Section: Case Presentationmentioning

confidence: 99%

Quantitative assessment of muscle injury by 23Na magnetic resonance imaging

et al. 2016

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Background23Na magnetic resonance imaging (23Na-MRI) is able to measure Na+ in vivo in humans and allows quantification of tissue sodium distribution. We now tested the utility of 23Na-MRI technique in detecting and assessing sports-related acute muscular injury.Case presentationWe assessed tissue Na+ of both lower legs with a 3T MRI scanner using a customized 23Na knee coil. The affected left calf muscle in an injured volleyball player showed a hyperintense Na+ signal. Follow-up measurements revealed persistently increased muscle Na+ content despite complete clinical recovery.ConclusionsOur findings suggest that 23Na-MRI could have utility in detecting subtle muscular injury and might indicate when complete healing has occurred. Furthermore, 23Na-MRI suggests the presence of substantial injury-related muscle electrolyte shifts that warrant more detailed investigation.

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3 Tesla 23Na Magnetic Resonance Imaging During Aerobic and Anaerobic Exercise

Cited by 25 publications

References 33 publications

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Quantitative sodium magnetic resonance imaging of cartilage, muscle, and tendon

Quantitative assessment of muscle injury by 23Na magnetic resonance imaging

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