Quantitative assessment of muscle injury by 23Na magnetic resonance imaging

Dahlmann, Anke; Kopp, Christoph W.; Linz, Peter; Cavallaro, Alexander; Seuß, Hannes; Eckardt, Kai‐Uwe; Luft, Friedrich C.; Titze, Jens; Uder, Michael; Hammon, Matthias

doi:10.1186/s40064-016-2193-6

Cited by 14 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally we measured significantly higher fat/water volume in the calf of lipedema patients, indicating both elevated intramuscular adipose tissue and reduced muscle size. While elevated sodium has also been observed throughout the muscle in the case of anaerobic exercise 21 , local muscle injuries 22 , or essential hypertension with increasing age 12 , 23 , lipedema is the first condition in which we have observed both increased muscle sodium and adipose content. This suggests that myopathy may be a clinical feature of lipedema that is consistent with the frequently reported symptom of chronic fatigue.…”

Section: Discussionsupporting

confidence: 49%

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Crescenzi

Marton

Donahue

et al. 2017

Obesity

Self Cite

View full text Add to dashboard Cite

Objective To test the hypothesis that tissue sodium and adipose content are elevated in patients with lipedema; if confirmed, this could establish precedence for tissue sodium and adipose content representing a discriminatory biomarker for lipedema. Methods Participants with lipedema (n=10) and control (n=11) volunteers matched for biological sex, age, body-mass-index, and calf circumference were scanned noninvasively with 3.0T sodium and conventional proton MRI. Standardized tissue sodium content was quantified in skin, subcutaneous adipose tissue (SAT), and calf muscle. Dixon MRI was employed to quantify tissue fat and water volumes of the calf. Nonparametric statistical tests were applied to compare regional sodium content and fat-to-water volume ratio between groups (significance: two-sided p≤0.05). Results Skin (p=0.01) and SAT (p=0.04) sodium content were elevated in lipedema (skin: 14.9±2.9 mmol/L; SAT: 11.9±3.1 mmol/L) relative to control (skin: 11.9±2.0 mmol/L; SAT: 9.4±1.6 mmol/L) participants. Relative fat volume in the calf was elevated in lipedema (1.2±0.48 ratio) relative to control (0.63±0.26 ratio, p<0.001) participants. Skin sodium content was directly correlated with fat-to-water volume ratio (Spearman’s-rho=0.54, p=0.01). Conclusions Internal metrics of tissue sodium and adipose content are elevated in patients with lipedema potentially providing objective imaging-based biomarkers for differentially diagnosing the under-recognized condition of lipedema from obesity.

show abstract

Section: Discussionsupporting

confidence: 49%

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Crescenzi

Marton

Donahue

et al. 2017

Obesity

Self Cite

View full text Add to dashboard Cite

show abstract

“…For instance, tissue sodium is altered in other diseases of pain and inflammation. Sodium is elevated in soft tissues of patients with scleroderma (18) and after acute injury (24); tissue sodium is reduced in load‐bearing articular cartilage in osteoarthritis (25) and intervertebral discs with degenerative disc disease (26). While the specific source of pain in lipedema remains unknown, pain on palpation (27), joint pain and nociceptive pain (10), central sensitization (28), and autonomic peripheral neuropathies (1) are suggested and should be investigated further using sodium MRI in well‐characterized cohorts with lipedema.…”

Section: Discussionmentioning

confidence: 99%

Upper and Lower Extremity Measurement of Tissue Sodium and Fat Content in Patients with Lipedema

Crescenzi

Donahue

Petersen

et al. 2020

Obesity

View full text Add to dashboard Cite

Objective: The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI). Methods: MRI was performed at 3.0 T in females with lipedema (n = 15, age = 43.2 ± 10.0 years, BMI = 30.3 ± 4.4 kg/m 2 ) and controls without lipedema (n = 14, age = 42.8 ± 13.2 years, BMI = 28.8 ± 4.4 kg/m 2 ). Participants were assessed for pain and disease stage. Sodium MRI was performed in the forearm and calf to quantify regional tissue sodium content (TSC, mmol/L). Chemical-shift-encoded water-fat MRI was performed in identical regions for measurement of fat/water (ratio). Results: In the calf, skin TSC (16.3 ± 2.6 vs. 14.4 ± 2.2 mmol/L, P = 0.04), muscle TSC (20.3 ± 3.0 vs. 18.3 ± 1.7 mmol/L, P = 0.03), and fat/water (1.03 ± 0.37 vs. 0.56 ± 0.21 ratio, P < 0.001) were significantly higher in participants with lipedema versus control participants. In the forearm, skin TSC (13.4 ± 3.3 vs. 12.0 ± 2.3 mmol/L, P = 0.2, Cohen's d = 0.50) and fat/water (0.65 ± 0.24 vs. 0.48 ± 0.24 ratio, P = 0.07, Cohen's d = 0.68) demonstrated moderate effect sizes in participants with lipedema versus control participants. Calf skin TSC was significantly correlated with pain (Spearman's rho = 0.55, P = 0.03) and disease stage (Spearman's rho = 0.82, P < 0.001) among participants with lipedema. Conclusions: MRI-measured tissue sodium and fat content are significantly higher in the lower extremities, but not upper extremities, of patients with lipedema compared with BMI-matched controls.Obesity (2020) 28, 907-915.

show abstract

“…However, as RF antennae are designed to achieve the best filling factor for the sample of interest to maximize SNR, space becomes a problem. Adequate space within the FOV is possible for muscle and breast MR imaging [113,114]. Such calibration phantoms at the edge of the FOV are located in regions of high B 0 and B 1 inhomogeneity near the RF coil.…”

Section: 0 Overcoming the Previous Challenges Of 23na Mr Imagingmentioning

confidence: 99%

Quantitative sodium MR imaging: A review of its evolving role in medicine

Thulborn

2018

NeuroImage

142

View full text Add to dashboard Cite

Sodium magnetic resonance (MR) imaging in humans has promised metabolic information that can improve medical management in important diseases. This technology has yet to find a role in clinical practice, lagging proton MR imaging by decades. This review covers the literature that demonstrates that this delay is explained by initial challenges of low sensitivity at low magnetic fields and the limited performance of gradients and electronics available in the 1980s. These constraints were removed by the introduction of 3T and now ultrahigh (≥7T) magnetic field scanners with superior gradients and electronics for proton MR imaging. New projection pulse sequence designs have greatly improved sodium acquisition efficiency. The increased field strength has provided the expected increased sensitivity to achieve resolutions acceptable for metabolic interpretation even in small target tissues. Consistency of quantification of the sodium MR image to provide metabolic parametric maps has been demonstrated by several different pulse sequences and calibration procedures. The vital roles of sodium ion in membrane transport and the extracellular matrix will be reviewed to indicate the broad opportunities that now exist for clinical sodium MR imaging. The final challenge is for the technology to be supplied on clinical ≥3T scanners.

show abstract

Quantitative assessment of muscle injury by 23Na magnetic resonance imaging

Cited by 14 publications

References 7 publications

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Upper and Lower Extremity Measurement of Tissue Sodium and Fat Content in Patients with Lipedema

Quantitative sodium MR imaging: A review of its evolving role in medicine

Contact Info

Product

Resources

About