3-Methyl-Histidin�mie und Niereninsuffizienz

Abstract

In 71 patients with different stages of renal disease, a close linear correlation was found between the concentration of "true creatinine" in the serum and that of 3methyl-histidine (r~0.79). First orientational investigations indicate that the excretion mechanism of 3-methyl-histidine is fundamentally different from that of histidine. Histidine is filtered glomerularly, and 5-7 % of the filtered volume appears in the urine; 3-methyl-histidine is filtered and secreted as well. In healthy subjects, the clearance of 3-methyl-histidine is three times higher than the endogenous creatinine clearance, and it falls below the creatinine clearance when renal function is severely impaired.

Influence of a meat‐free diet on the urinary excretion of 3‐methylhistidine and creatinine in chronic renal failure

“…In healthy subjects, 3-methylhistidine excretion equilibrates at a lower level 46-72 h after exclusion of meat from the diet, provided that protein intake is kept constant [2]. 3-methylhistidine is excreted by the kidneys through both glomerular filtration and tubular secretion, and excretion is thus markedly impaired in renal failure [3].…”