The article describes the immobilization of yeast cells Ogataea polymorpha VKM Y-2559 into organosilicon matrices based on tetraethoxysilane and dimethyldiethoxysilane using polyethylene glycol, polyvinyl alcohol and chitosan as structure-controlling agents. The in uence of the structure-control agent on the time of formation of the sol-gel capsule around the cells and on the morphology of the hybrid material was determined. The formation of organosilicon material was con rmed using IR spectroscopy. Using the method of energy-dispersive X-ray spectroscopy, it was proven for the rst time that the structure-controlling agent is not incorporated into the structure of the organosilicon shell.