(3-Hydroxypiperidin-1-yl)(4-methylphenyl)methanone

Abstract

In the title molecule, C 13 H 17 NO 2 , the piperidine ring assumes a chair conformation. The dihedral angle between the mean plane of the piperidine ring and the benzene ring is 45.49 (1) . In the crystal, molecules are linked by O-HÁ Á ÁO intermolecular hydrogen bonds, leading to a molecular chain running along the c-axis direction. The atoms of the hydroxy piperidine ring and the methyl group of methylphenyl ring are disordered over two sets of sites with refined occupancies of 0.754 (5) and 0.246 (5). Structure descriptionPiperidine and its derivative have played vital roles in the design of pharmaceutical drugs (Das & Brahmachari, 2013). It has been shown that the antioxidant activity of the title molecule can be enhanced by the substitution of hydroxyl, methoxy, nitro and alkyl groups on the piperidine ring system (Ravindernath & Reddy, 2017).In the compound (Fig. 1)