3-Hydroxymethylglutaryl Flavonol Glycosides from a Mongolian and Tibetan Medicine, Oxytropis racemosa

Identification of phenolic constituents of Cytisus multiflorus

“…Luteolin derivatives containing a 144 Da moiety were previously described by Ferreres, Sousa, et al (2007) in Passiflora genus, although at that time, these authors have not proposed a structural feature for that unit. Yet, the same fragmentation pattern (À62 Da, À102 Da and À144 Da) has been previously assigned to 3-hydroxy-3-methylglutaroyl flavonoid glycosides in Citrus bergamia (Di Donna et al, 2009) and in Oxytropis racemosa plant of Fabaceae family (Song et al, 2010). Thus, based on that data, these results suggest the existence of a 3-hydroxy-3-methylglutaroyl derivative of 2 00 -O-pentosyl-C-hexosyl-luteolin in C. multiflorus.…”

“…As described before for the luteolin derivative in fraction 6 (MW 724 Da), the presence of an 3-hydroxy-3-methylglutaric acid moiety was proposed based on literature data (Di Donna et al, 2009;Song et al, 2010). Apigenin derivatives containing a 144 Da moiety were also previously described by Ferreres, Sousa, et al (2007) in Passiflora genus, although no structural feature was proposed.…”

Rapid Identification of Unstable Acyl Glucoside Flavonoids of Oxytropis racemosa Turcz by High‐performance Liquid Chromatography–Diode Array Detection–Electrospray Ionisation/Multi‐stage Mass Spectrometry

“…Among the 32 components, 13 compounds ( 1 , 7 , 11 , 13 , 16–18 , 20, 22 , 24 , 28 , 30 and 31) with ( S )‐3‐hydroxy‐3‐methylglutaroyl moieties and four compounds ( 19 , 25 , 29 and 32) with malonyl moieties were the characteristic constituents of the medicinal plant. In addition, 10 compounds ( 1 , 7 , 18‐20 , 22 , 25 , 28 , 29 and 32 ) were characterised as new compounds because of their acylated sugar moieties, which have rarely been reported previously (Song et al ., ).…”

“…Thirty‐two flavonoids were tentatively identified by the detailed analysis of their mass spectra fragmentation, UV spectral characteristics and chromatography behaviours. Furthermore, 13 flavonoids were confirmed by comparison with previously isolated compounds obtained from O. racemosa (Song et al ., ). Among these 32 flavonoids, 10 were characterised as new compounds because of their acylated sugar with either 3‐hydroxy‐3‐methylglutaroyl or malonyl moieties.…”

DNA Topoisomerase Inhibitory Activity of Constituents from the Fruits of <i>Illicium verum</i>

“…In addition, naturally occurring HMG esters were speculated to be biosynthesized by nucleophilic substitution between a nucleophilic hydroxyl group or RO − and (S)-hydroxymethylglutaryl-CoA (HMGCoA), as this mode of biosynthesis is widely used to produce terpenoids and other natural products. [24][25][26][27] Compound 3 had the molecular formula C 16 (9) 33) and shikimic acid (10). 34) None of ten compounds showed any topoisomerase I inhibitory activity at concentrations of less than 100 µM, but compounds 3, 5, 6, and 8-10 inhibited the activity of topoisomerase II with IC 50 values of 54.6, 25.5, 17.9, 12.1, 0.3 and 1.0 µM, respectively (Fig.…”