3-Formylchromones: Potential antiinflammatory agents

3-Formylchromone Interacts with Cysteine 38 in p65 Protein and with Cysteine 179 in IκBα Kinase, Leading to Down-regulation of Nuclear Factor-κB (NF-κB)-regulated Gene Products and Sensitization of Tumor Cells

“…While searching for such agents, we focused on chromones, which have been linked with antibacterial, antifungal, and antitumor activities (1). In particular, we focused on 3-formylchromone (3-FC), 3 which has been shown to exhibit antibacterial (2), anti-inflammatory (3), and antitumor (2, 4 -6) activities. How this agent exhibits all these activities is not fully understood, but inhibition of protein-tyrosine phosphatase 1B (7), chelation of bivalent cations (8), multidrug resistance (5), p56 lck tyrosine kinase (9), and thymidine phosphorylase (10) have been implicated.…”

Chemistry and application of 4-oxo-4H-1-benzopyran-3-carboxaldehyde

“…The Schiff bases prepared from 1 and several arylamines have been evaluated for their antibacterial activities. [42][43][44] The Schiff base 54 has been prepared from 1 and 4-aminoantipyrine by conventional method 45 as well as in an ionic liquid. 46 Many other hetarylamines such as 1,3-diaryl-5-aminopyrazole 55, 47 3-Formylchromones as well as Schiff bases obtainable therefrom can function as ligands towards many metal ions.…”

Novel series of phenylalanine analogs endowed with promising anti-inflammatory activity: synthesis, pharmacological evaluation, and computational insights

“…1, many Schiff bases are known to be medicinally important and have been found to be promising leads for the design of more efficient antiinflammatory agents. In the past decade, Schiff bases of different heterocycles have displayed remarkable antiinflammatory activity with reduced ulcerogenic effect (Alam et al, 2012;Hunashal et al, 2011;El-Sayed et al, 2011;Khan et al, 2010). Studies also demonstrated that the metal complexes of Schiff bases display enhanced biological activity than their respective free organic compounds (Chohan et al, 1997).…”