Chemistry and application of 4-oxo-4H-1-benzopyran-3-carboxaldehyde

Abstract

The publications on the title compound appearing mainly since 2007 to February 2014 are reviewed.

Cyclative MCRs of Azines and Azinium Salts

“…The method offered several advantages including mild condition, easy experimental workup procedure, and high yields. Unique features make the chromone [138] amenable to various reactions as defunctionalization, oxidation and reduction, radical and nucleophilic addition, and many types of annulations and cycloaddition reactions. [139,140] In 2009, synthesis of chromenopyrido isoquinoline derivatives (206) by three-component reaction of isoquinoline (203), chromone-3-carboxaldehyde (204), acetylene dicarboxylate (205) was reported by Stephanatou and Tsoleridis.…”

Recent advances in the synthesis of 4H-chromen-4-ones (2012 − 2021)

“…The synthesis and reactivity of 2-acyl-4H-chromen-4-ones, 11 of 2-aryl-and 2-aryl-3-substituted 4H-chromen-4-ones, 12 of halo-4H-chromen-4-ones, 13 of 4-oxo-4H-chromen-3-carbaldehydes, 14 of 4-oxo-4H-chromen-3-carbonitriles 15 of 2-methyl-4-oxo-4H-chromen-3carboalkoxides, 16 of 4-oxo-4H-chromen-3-carboxylates and 4-oxo-4Hchromen-3-ylglyoxalates, 17 of electron-deficient 3-vinyl-4H-chromen -4-ones 18 and 4H-chromen-4-ones polyfluorinated in A-ring, 19 have been detailed in minireviews. The synthesis of furochromones, their transformation and biological activities has also reviewed.…”

Ultrasound-Promoted Kabachnik–Fields Synthesis of Novel Chromonyl α-Aminophosphonate Derivatives Incorporating Nitrogen Heterocycles Using CdI2 Nanoparticles as an Efficient Catalyst: Evaluation of Their Antifungal Properties

“…[3][4][5] 4-Oxo-4H-chromenes are an essential class of oxygen-containing heterocyclic compounds. 6 They are well known to be powerful pharmacophores in several drugs and flavonoids. 7 In addition, several chromones demonstrated numerous medicinal and biological functions including antioxidant, 8 anticancer, 9 antifungal, 10 anti-HIV 11 and anti-inflammatory.…”