Synthesis of some novel chromonyl α-aminophosphonate esters clubbed with nitrogen heterocycles, was achieved. The methodology based on one-pot three-components reaction of 4-oxo-4H-chromene-3-carboxaldehydes, N-aminoheterocycles and diethyl phosphite in the presence of CdI2 nanoparticles as an efficient catalyst under conventional heating at 80 o C or ultrasound (US) irradiation at 50 o C. The mild reaction conditions, operational simplicity and excellent yields are the essential advantages of this protocol. The antifungal properties of the products were evaluated. Most of them recorded inhibitory effects towards plant pathogenic fungi nearly to the standard control. The hybridization between diethyl α-aminophosphonate and 6-methylchromone moieties with antipyrine, morpholine or 1,2,4-triazine in one molecular frame led to promising antifungal agents against plant pathogenic fungi.