2012
DOI: 10.1038/ja.2012.46
|View full text |Cite
|
Sign up to set email alerts
|

3′-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species

Abstract: CXCL10 (IP-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells such as macrophages and T-lymphocytes and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 (MM6) cells, the new diaryl ether 3 0 -demethyldihydromaldoxin (1) along with the known compound dihydromaldoxin (2), were isolated from fermentations of a Steganospora species. The structures of the compounds were elucidated by a c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
7
0

Year Published

2013
2013
2024
2024

Publication Types

Select...
3
1

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(7 citation statements)
references
References 21 publications
0
7
0
Order By: Relevance
“…The mRNA expression in human Colo 320 cells was analyzed by two-step real-time RT-PCR as described before [39] with gene-specific primers for human survivin (Genbank Accession NM001168) forward: 5´-ACCAGGTGAGAAGTGAGGGA-3´ and reverse: 5´-AACAGTAGAGGAGCCAGGGA-3´ (size of the PCR product is 309 bp) and GAPDH (Genbank Accession M33197) forward: 5’-CCTCCGGGAAACTGTGG-3’ and reverse: 5’-AGTGGGGACACGGAAG-3’ (size of the PCR product is 140 bp). Relative mRNA amounts were determined using the mathematical model for relative quantification in real-time PCR proposed by Pfaffl [40].…”
Section: Methodsmentioning
confidence: 99%
“…The mRNA expression in human Colo 320 cells was analyzed by two-step real-time RT-PCR as described before [39] with gene-specific primers for human survivin (Genbank Accession NM001168) forward: 5´-ACCAGGTGAGAAGTGAGGGA-3´ and reverse: 5´-AACAGTAGAGGAGCCAGGGA-3´ (size of the PCR product is 309 bp) and GAPDH (Genbank Accession M33197) forward: 5’-CCTCCGGGAAACTGTGG-3’ and reverse: 5’-AGTGGGGACACGGAAG-3’ (size of the PCR product is 140 bp). Relative mRNA amounts were determined using the mathematical model for relative quantification in real-time PCR proposed by Pfaffl [40].…”
Section: Methodsmentioning
confidence: 99%
“…Its structure was established by detailed analysis of its NMR data, and the position of the chlorine atom in penicillither ( 28) was postulated at C-6 based on the possible biosynthetic pathway from the co-isolated chlorobenzopheneone. 31 Chemical investigation into a fungus Aspergillus iizukae isolated from coastal saline soil in Kenli, China, led to purify a new analog iizukine A (29) along with several known ones, and the chlorine atom was connected at C-4 not C-6 in iizukine A (29), different from penicillither (28), though similar NMR data were observed in these metabolites. 32 Diphenyl ether derivatives are kind of common fungi secondary metabolites.…”
Section: T H I S C O N T E N T Imentioning
confidence: 99%
“…In a search for new inhibitors of CXCL10 expression, a new diaryl ether 3′-demethyldihydromaldoxin ( 26 ) along with the known analog dihydromaldoxin ( 14 ), was isolated from Steganospora sp. IBWFE07110 . The structures were analyzed by a combination of 1D-, 2D-NMR, and MS spectroscopies together with comparison of asterric acid NMR data.…”
Section: Structures Of Naturally Occurring Asterric Acid Analoguesmentioning
confidence: 99%
See 2 more Smart Citations