(3,5-Dimethyladamantan-1-yl)ammonium methanesulfonate (memantinium mesylate): synthesis, structure and solid-state properties

Tuksar, Mihaela; Rubčić, Mirta; Meštrović, Ernest

doi:10.1107/s2056989019009988

Cited by 1 publication

(1 citation statement)

References 13 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, a pursuit for novel pharmaceutically acceptable salts of memantine or their different forms, which would offer better properties compared to hydrochloride salt, is justified. Significant efforts were made to characterize alternative solid forms of memantine, such as carboxylates 22,23 and sulfonates, 24,25 but simple inorganic salts were not explored. Herein, we present a comprehensive study focused on pharmaceutically acceptable inorganic salts, namely, hydrogen sulfate, sulfate, and dihydrogen phosphate salts of memantine.…”

Section: ■ Introductionmentioning

confidence: 99%

Exploring Salts of Memantine with Inorganic Anions: From Polymorphism and Solid-State Transitions to Potential for Drug Formulations

Tuksar,

Topić,

Rubčić

et al. 2024

Mol. Pharmaceutics

View full text Add to dashboard Cite

This study examines pharmaceutically acceptable inorganic salts of memantine, specifically focusing on hydrogen sulfate, sulfate, and dihydrogen phosphate salts, with the aim of finding alternatives to the commonly used chloride salt in the treatment of Alzheimer’s disease. Through comprehensive solid-state characterization, including powder X-ray diffraction, thermal analysis, and solubility testing, we unveil complex polymorphic behaviors, reversible solid-state transitions, and significant differences in solubility and stability among the salts. Notably, the hydrogen sulfate salt emerges as a promising candidate for drug formulations, offering improved solubility, nonhygroscopic nature, and favorable morphological characteristics compared to the existing chloride salt. This work establishes a foundation for further investigation into memantine salts as potential therapeutics with improved efficacy.

show abstract