Exploring Salts of Memantine with Inorganic Anions: From Polymorphism and Solid-State Transitions to Potential for Drug Formulations
Mihaela Tuksar,
Edi Topić,
Mirta Rubčić
et al.
Abstract:This study examines pharmaceutically acceptable inorganic
salts
of memantine, specifically focusing on hydrogen sulfate, sulfate,
and dihydrogen phosphate salts, with the aim of finding alternatives
to the commonly used chloride salt in the treatment of Alzheimer’s
disease. Through comprehensive solid-state characterization, including
powder X-ray diffraction, thermal analysis, and solubility testing,
we unveil complex polymorphic behaviors, reversible solid-state transitions,
and significant differences in so… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.