3,5-Bis(4-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

Abstract

In the title compound, C21H16F2N2, the dihedral angle between the fluoro­phenyl groups is 66.34 (8)°, and the dihedral angle between the envelope-configured pyrazole group (N/N/C/C/C) and the benzene ring is 11.50 (9)°. The dihedral angles between the benzene and the two fluoro-substituted phenyl groups are 77.7 (6) and 16.7 (5)°. Weak C—H⋯π interactions contribute to the stability of the crystal structure.

Crystal structure of (2E)-3-(4-benzyloxyphenyl)-1-(4,4’’-difluoro-5’- methoxy-1,1’:3’,1’’-terphenyl-4’-yl)prop-2-en-1-one, C35H26F2O3

“…Chalconesare highly reactive substances of varied nature. They have been reported to possess many interesting pharmacological activities [2] including anti-inflammatory, antimicrobial, antifungal, antioxidant, cytotoxic, antitumor and anticancer activities [3,4].Inview of the pharmacological importance of terphenyls and chalcones and in continuation of our work on the synthesis of various derivatives of 4,4'-difluoro chalcone [5][6][7][8] we herein report the crystal and molecular structure of the title compound. The C=C double bond shows (E)-configuration.…”

Crystal structure of (2E)-3-(biphenyl-4-yl)-1-(4,4’’-difluoro-5’-methoxy- 1,1’:3’,1’’-terphenyl-4’-yl)prop-2-en-1-one, C34H24F2O2

“…being potent anticoagulants, immuno-suppressants, antithrombotics, neuroprotectives, specific 5-lipoxygenase inhibitors) and showing cytotoxic activities [4]. In view of the pharmacological importance of terphenyls and chalcones, and in continuation of our work on synthesis of various derivatives of 4,4'-difluoro chalcone [5][6][7][8], the molecular and crystal structure of the title compound is reported. The C=C double of the Michael system is (E)-configured.…”

Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines

“…1)Jasinski et al, 2010a, b; Baktir et al, 2011;Butcher et al, 2011). The IR spectra of all the compounds showed -C=N-stretch at 1580-1595 cm -1 confirmed the formation of pyrazoline moiety.…”

“…Among the methods employed in synthesis of pyrazolines, condensation of substituted chalcones with hydrazine and its derivatives is commonly used (Knorr, 1893;Thakare and Wadodkar, 1986;Ankhiwala and Hathi, 1996;Azarifar and Ghasemnejad, 2003). In view of the importance of 2-pyrazolines and in continuation of our work on pyrazolines Jasinski et al, 2010a, b;Fun et al, 2010;Baktir et al, 2011), we report the synthesis and biological evaluation of some 1,3,5-triaryl-2-pyrazolines.…”