Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines

Abstract

A series of 1,3,5-triaryl-2-pyrazolines 2a-g were synthesized by the reaction of 4,4 0 -disubstituted chalcone with phenyl hydrazine. All these compounds were characterized by NMR, IR and mass spectral and single crystal XRD data. All the synthesized products were screened for their in vitro antimicrobial, analgesic and antioxidant properties. The docking studies were carried out for these compounds against the active site of methionyl-tRNA synthetase (metRS). Some of the tested compounds exhibited significant antimicrobial, analgesic, DPPH scavenging activities and molecular binding.

Reaction of ethyl acetoacetate and 2′-hydroxychalcones: Efficient route to 9-aryl-6<i>H</i>-benzo[c]chromen-6-ones

“…The Michael addition of active methylene compounds to chalcones is well documented [15][16][17][18][19][20]. On the basis of these precedents, the formation of chromenone 17 was thought to proceed by first a Michael addition of ethyl acetoacetate 14 to chalcone 8 followed by intra-molecular trans-esterification and intramolecular Aldol condensation to give intermediate 15.…”

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“…Evaluation of Antimicrobial Activity: The in vitro antimicrobial studies were carried out by agar well diffusion method 35,36 . Preparation of nutrient broth, subculture and agar medium were done as per standard procedure.…”

1H and 13C NMR spectral assignments for 24 novel naphthalenylphenylpyrazolines

“…B), and 1,3,5‐triphenyl (Fig. C) groups show anti‐inflammatory, antimicrobial, and anti‐tubercular activities, respectively . We designed pyrazolines containing 3‐phenyl and 5‐naphthalenyl (Fig.…”