3,4-Dihydro-3-methyl-6-nitro-2H-1,3-benzoxazin-2-one, a Reagent for Labeling p-Nitrophenyl Esterases with a Chromophoric Reporter Group - Synthesis and Reaction with Chymotrypsin

Synthesis, Hydrolysis, and Evaluation of 3-Acylamino-3,4-dihydro-2-oxo-2H-1,3-benzoxazinecarboxylic Acids and Linear Azadepsipeptides as Potential Substrates/Inhibitors of β-Lactam-Recognizing Enzymes

“…Moreover, if a β‐lactamase were to be acylated by a dihydrobenzoxazinone, the presence of this atom should also stabilize the acyl enzyme. A derivative of the parent heterocycle, 3,4‐dihydro‐3‐methyl‐6‐nitro‐2 H ‐1,3‐benzoxazin‐2‐one 3 , is known to react with chymotrypsin,4 whereas several of its analogues or homologues result in the production, with cholinesterases, of stabilized carbamoyl‐bound enzymes 5,6…”

Complexation of tris(pentafluorophenyl)silanes with neutral Lewis bases

“…Silanes TPFS-Cl [33], TPFS-F [4b], TPFS-OTf [34], N-(2-hydroxybenzoyl)pyrrolidinone [35], N-methyl-N-[2-hydroxybenzyliden]amine [36], 1-tris(pentafluorophenyl)silyloxycyclopentene [34], and amide 8 [37] were synthesized according to the literature procedures. HMPA and NMP were distilled in vacuum from CaH 2 and stored under argon over MS 4A.…”

Phenolic Structure and Colour in Mannich Reaction Products

“…(lit. 19 58°C, and lit., 20 an oil, both by the same method, from reduction of salicylmethylimine NO,137.0841. N,N-Bis(2-Hydroxybenzyl)methylamine: With equimolar quantities (0.033 mol) of phenol and methylamine, reaction at ambient temperature during 24 h, the syrupy reaction mixture showed three products (TLC) which were separated by prep.…”