3[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]-2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia

Palladium(II) Catalyzed Cyclization-Carbonylation-Cyclization Coupling Reaction of (ortho-Alkynyl Phenyl) (Methoxymethyl) Sulfides Using Molecular Oxygen as the Terminal Oxidant

“…We are currently investigating further biological studies of the synthesized compounds 2. Benzo [b]thiophene skeletons are an important class of S-heterocycles [15][16][17][18] and are found in a variety of drugs, pesticides, and biologically active compounds that exhibit various interesting biological properties [19][20][21][22][23][24]. Diaryl ketone scaffolds are also important motifs in natural products and pharmaceuticals [25][26][27][28][29][30] (Figure 1).…”

Solution-Phase Parallel Synthesis of a Multi-substituted Benzo[b]thiophene Library

“…as antitumor,8-10 antibacterial,11 antibiotic,12 antipsychotic,13 anti-inflammatory,14-16 antiallergic,17 antimicrobial,18 antithrombotic-fibrilonitic19 and antifungal20 agents. Indeed, raloxifene ( 1 ) and arzoxifene ( 2 ) have well-recognized pharmacological properties, serving as potent selective estrogen receptor modulators (SERMs),21-30 as well as tubulin-binding agents,21,31-34 to name just a few.…”

Synthesis of some novel methylene‐bis‐pyrimidinyl‐spiro‐4‐thiazolidinones as biologically potent agents

“…Recently more attention has been directed towards the synthesis of thiazolidinone bearing heteryl pharmacophores [3] as some of the deriva-tives have displayed significant pharmacological [4], and biological activities [5] including sedative [6], antiinflam-matory [7], antibacterial [8], antifungal [9], antitubercu-lar [10], analgesic and hypothermic [11], local [12a] and spinal [12b] anesthetic, CNS stimulant [13], anti-HIV [14] and nematicidal [15]. Further, thiazolidinones have also been used for the treatment of cardiac diseases [16], diabetic complications like cataracts, nephropathy and neuropathy [17], and selective anti-platelet activating factor [18]. Inspite of wide applications, it has been observed that there is scant information on the synthesis of thiazolidinones possessing heteryl substituted pyrimidinyl moiety in the literature.…”