3,3′-Diselenodipropionic acid (DSePA) induces reductive stress in A549 cells triggering p53-independent apoptosis: A novel mechanism for diselenides

Unravelling the molecular interaction of diselenodipropionic acid (DSePA) with human serum albumin (HSA)

“…Inevitably the transport and metabolic pathways of DSePA, which play a crucial role in its activity needs to be understood. 2,24…”

“…23 Recently we studied the anti-cancer effects of DSePA in A549, human lung cancer cells, where DSePA showed a significant concentration and time-dependent anticancer ability. 2,24 Mechanism for these important pharmacological activities has also been identified. Inevitably the transport and metabolic pathways of DSePA, which play a crucial role in its activity needs to be understood.…”

“…Inevitably the transport and metabolic pathways of DSePA, which play a crucial role in its activity needs to be understood. 2,24 HSA is an important extracellular carrier protein in humans; it possesses a unique capability to bind non-covalently (such as van der Waals forces, hydrogen bonding and ionic interactions) and transport a wide variety of endogenous and exogenous nutrients as well as drugs to the cells. [25][26][27][28][29] This monomeric globular protein is composed of three homologous domains, domain I (amino acid residues 1-195), domain II (196-383; site I) and domain III (384-585; site II), respectively.…”

3,3′-Diselenodipropionic acid immobilised gelatin gel: a biomimic catalytic nitric oxide generating material for topical wound healing application

“…57 The compound DSePA has previously been reported to exhibit GPx-like activity and inhibit ROS-mediated lipid peroxidation. 32–35 Notably, our results indicated that gelatin–DSePA conjugate exhibited higher GPx-like activity than DSePA. In agreement with this observation, G–Se–Se–G gel treatment showed a significantly lower level of lipid peroxidation as compared to the control groups.…”

Selenium metabolism and regulation of immune cells in immune‐associated diseases

“…Targeting tumor cells like leukemia stem cells, selenium can activate ATM kinase to promote the expression of p53 to regulate glycolysis, oxidative phosphorylation, and glutamine pathway of tumor cells, resulting in specific increase of ROS in tumor cells and apoptosis (Diwakar et al, 2017; Gandhi et al, 2021; Jackson, 2012; Kim et al, 2021; Sun et al, 2021). This effect is opposite to what happens in normal cells or damaged normal cells.…”