Selenium metabolism and regulation of immune cells in immune‐associated diseases

Niu, Ruiying; Yang, Qiuli; Dong, Yingjie; Hou, Yueru; Liu, Guangwei

doi:10.1002/jcp.30824

Cited by 8 publications

(5 citation statements)

References 117 publications

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“…This is similar to the results of our in vitro experiment, providing a research direction for subsequent in vivo experiments. In previous studies, selenium can synergize with sufficient IL-4 to activate the receptor γ (PPAR-γ)-reliant pathway, promoting macrophages from M1 to M2 [ 43 ]. In this experiment, Se-MOP can increase the relative expression of IL-4.…”

Section: Discussionmentioning

confidence: 99%

Selenium Nanoparticles Based on Morinda officinalis Polysaccharides: Characterization, Anti-Cancer Activities, and Immune-Enhancing Activities Evaluation In Vitro

et al. 2023

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Recently, selenium nanoparticles have been drawing attention worldwide, and it is crucial to increase the stability of nano-Se. Morinda officinalis polysaccharides (MOP) are the main active component in Morinda officinalis radix. However, their low activity has limited their application. A novel selenium nanoparticle (Se-MOP) was prepared to solve these problems using MOP as a dispersant. The zeta potential was measured to evaluate the stability, and UV and ATR-FTIR were used to investigate the binding type of selenium and MOP. The morphology was observed by the TEM method. Furthermore, the inhibitory effect on five selected cancer cells (HepG2, MCF-7, AGS, PC9, and HCT8) was evaluated, showing remarkable inhibition of all five cancer cells. The mechanism of inhibition was also investigated by cell circle assay, and it was found that Se-MOP could induce cell circle G0/G1 phase arrest. Immune-enhancing activities were evaluated by measuring the proliferation and cytokines of mouse spleen lymphocytes in vitro and quantitative RT-PCR. The results indicated that single stimulation of Se-MOP and synergistic stimulation with PHA or LPS increased immune capacity and improved immune by increasing the expression of cytokines.

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Section: Discussionmentioning

confidence: 99%

Selenium Nanoparticles Based on Morinda officinalis Polysaccharides: Characterization, Anti-Cancer Activities, and Immune-Enhancing Activities Evaluation In Vitro

et al. 2023

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“…Patients with ESRD treated by dialysis have significantly lower blood Se levels than the healthy population due to decreased appetite, inadequate dietary intake, and its loss during dialysis [ 199 ]. Se is an important trace element in the human body, which has a regulatory role in maintenance of metabolic activities of the body [ 200 ]. In the body, it is involved in various physiological processes in the form of selenoproteins containing selenocysteine in the active center [ 201 , 202 ].…”

Section: Potential Mechanisms By Which Se May Improve Malnutritionmentioning

confidence: 99%

Progress in the study of nutritional status and selenium in dialysis patients

et al. 2023

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Malnutrition is very common in patients with chronic kidney disease, especially in those on maintenance dialysis. Malnutrition is one of the major factors affecting survival and death of dialysis patients, and reducing their activity tolerance and immunity. There are numerous and interacting risk factors for malnutrition, such as reduced nutritional intake, increased energy expenditure, hormonal disorders, and inflammation. Selenium, in the form of selenoproteins, is involved in many physiological processes in the body and plays an important role in maintaining redox homeostasis. Oxidative stress and infection are very common in dialysis patients, and selenium levels in dialysis patients are significantly lower than those in the healthy population. It has been shown that there is a correlation between selenium levels in hemodialysis patients and their nutrition-related indicators, and that selenium supplementation may improve malnutrition in patients. However, further studies are needed to support this conclusion and there is a lack of basic research to further characterize the potential mechanisms by which selenium may improve malnutrition in dialysis patients. The purpose of this review is to provide a comprehensive overview of factors associated with malnutrition in dialysis patients and to describe the progress of research on nutritional status and selenium levels in dialysis patients.

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“…Se also affects the function of various immune cells in fish, such as macrophages and lymphocytes, as it enhances the phagocytic activity of macrophages so that they can effectively engulf and eliminate pathogens [ 16 ]. It also modulates the production of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α), which are involved in the immune response against pathogens [ 17 ]. In addition, Se enhances lymphocyte proliferation and antibody production, promoting a robust immune response in fish.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Selenium on the Growth and Immune Systems of Fish

Sumana,

Chen,

Shui

et al. 2023

Animals

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Dietary selenium (Se) is an essential component that supports fish growth and the immune system. This review attempts to provide insight into the biological impacts of dietary Se, including immunological responses, infection defense, and fish species growth, and it also identifies the routes via which it enters the aquatic environment. Dietary Se is important in fish feed due to its additive, antioxidant, and enzyme properties, which aid in various biological processes. However, excessive intake of it may harm aquatic ecosystems and potentially disrupt the food chain. This review explores the diverse natures of dietary Se, their impact on fish species, and the biological methods for eliminating excesses in aquatic environments. Soil has a potential role in the distribution of Se through erosion from agricultural, industrial, and mine sites. The research on dietary Se’s effects on fish immune system and growth can provide knowledge regarding fish health, fish farming strategies, and the health of aquatic ecosystems, promoting the feed industry and sustainable aquaculture. This review provides data and references from various research studies on managing Se levels in aquatic ecosystems, promoting fish conservation, and utilizing Se in farmed fish diets.

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Selenium metabolism and regulation of immune cells in immune‐associated diseases

Cited by 8 publications

References 117 publications

Selenium Nanoparticles Based on Morinda officinalis Polysaccharides: Characterization, Anti-Cancer Activities, and Immune-Enhancing Activities Evaluation In Vitro

Selenium Nanoparticles Based on Morinda officinalis Polysaccharides: Characterization, Anti-Cancer Activities, and Immune-Enhancing Activities Evaluation In Vitro

Progress in the study of nutritional status and selenium in dialysis patients

Effect of Dietary Selenium on the Growth and Immune Systems of Fish

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