In this article, analytical modeling of two-dimensional heat conduction in a hollow sphere is presented. The hollow sphere is subjected to time-dependent periodic boundary conditions at the inner and outer surfaces. The Duhamel theorem is employed to solve the problem where the periodic and time-dependent terms in the boundary conditions are considered. In the analysis, the thermophysical properties of the material are assumed to be isotropic and homogenous. Moreover, the effects of the temperature oscillation frequency, the thickness variation of the hollow sphere, and thermophysical properties of the sphere are studied. The temperature distribution obtained here contains two characteristics, the dimensionless amplitude (A) and the dimensionless phase difference (ϕ). Moreover, the obtained results are shown with respect to Biot and Fourier numbers. Comparison between the present results and the findings from a previous study for a hollow sphere subjected to the reference harmonic state show good agreement.