2D-NMR investigation and in vitro evaluation of antioxidant, antigenotoxic and estrogenic/antiestrogenic activities of strawberry grape

D’Abrosca, Brigida; Lavorgna, Margherita; Scognamiglio, Monica; Russo, Chiara; Graziani, Vittoria; Piscitelli, Concetta; Fiorentino, Antonio; Isidori, Marina

doi:10.1016/j.fct.2017.03.050

Cited by 11 publications

(5 citation statements)

References 33 publications

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“…Due to the biological protective effect that functional foods have on cancer development, Isabella grape has been studied as a potential chemopreventive and therapeutic agent for the treatment of different neoplasms. The chemopreventive mechanisms reported for this grape variety include cytotoxicity, cell cycle modulation, prooxidant action, apoptosis induction, and regulation of hormone receptors [ [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. At this point, it is worth mentioning that breast cancer is the most frequently diagnosed type of neoplasm worldwide [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity and cytotoxic effect of an optimized extract of isabella grape (Vitis labrusca) on breast cancer cells

Vélez

Llano-Ramírez

Ramón-Palacio

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

Antioxidant capacity and cytotoxic effect of an optimized extract of isabella grape (Vitis labrusca) on breast cancer cells

Vélez

Llano-Ramírez

Ramón-Palacio

et al. 2023

Heliyon

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“…In recent years, the increasing interest in plant-derived healthy natural products has been focused on the research for normally consumed food and drinks whose natural chemical composition provides multi-purpose beneficial effects [11,[33][34][35]. Thus, assuming that cocoa and derivatives are consumed frequently and widely all over the world as reported by Tokede and collaborators [36] due to the highly attractive organoleptic characteristics [4], herein the combined approach between the evaluation of various biological activities (radical scavenging, antimutagenicity, antigenotoxicity, and cancer cells viability inhibitory effect), and the chemical composition analysis by UHPLC-ESI QqTOF-MS/MS of the selected cocoa beans was used.…”

Section: Discussionmentioning

confidence: 99%

Theobromacacao Criollo var. Beans: Biological Properties and Chemical Profile

Lavorgna

Pacifico

Nugnes

et al. 2021

Foods

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Theobroma cacao provides precious products such as polyphenol-rich beans that are useful for nutraceutical purposes. The geographical area may influence the chemical composition of raw cocoa beans in terms of the polyphenols and biological qualities of the products. This work aimed to investigate the biological properties and the chemical composition of two different samples of Criollo var. cocoa raw beans coming from two areas (Indonesia; Peru). Beans underwent biphasic extraction obtaining lipophilic and hydroalcoholic extracts. The extracts were tested for antiradical, antimutagenic, and antigenotoxic effects. Cell viability inhibition toward breast, gastric/esophageal colorectal adenocarcinoma, and hepatoblastoma human cell lines was evaluated. Extracts were chemically investigated through UV-Vis spectroscopy and ultra-high-pressure liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QqTOF MS/MS). Results showed that the Indonesian bean hydroalcoholic extracts were able to scavenge 2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) cation radical better than the Peruvian hydroalcoholic extracts (ECs50: 72.63 vs. 322.20 μg/mL). Extracts showed antimutagenic and antigenotoxic activity. The viability inhibitory effect on breast and hepatic cancer cells was reached only for the Indonesian hydroalcoholic extracts at hundreds of μg/mL. Phenylpropenoyl-L-amino acids, hydroxycinnamoyl aminoacids conjugates, and procyanidin compounds were found mainly in the hydroalcoholic extracts, whereas fatty acids and lyso-phospholipids were found mainly in lipophilic fractions. Fatty acid and (epi)catechins appeared to be affected by different environmental conditions of the geographical areas.

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“…This capacity has been used in many analytical approaches: metabolomics, identification of bioactive compounds in natural extracts, and characterization of species. () See references Larive et al,() Mahrous et Farag() and Wolfender et al() for recent reviews.…”

Section: Introductionmentioning

confidence: 99%

“…All species in the solution display their NMR spectra, with a signal intensity proportional to their relative concentrations, provided that slow tumbling rates or relaxation agents do not hide the lines by fast relaxation processes. This capacity has been used in many analytical approaches: metabolomics, identification of active compounds in natural extracts, characterization of species [1][2][3][4][5] . See references (6), (7), and (8) for recent reviews.…”

Section: Introductionmentioning

confidence: 99%

Automatic differential analysis of NMR experiments in complex samples

Margueritte

Markov

Chiron³

et al. 2018

Magnetic Reson in Chemistry

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Liquid state nuclear magnetic resonance (NMR) is a powerful tool for the analysis of complex mixtures of unknown molecules. This capacity has been used in many analytical approaches: metabolomics, identification of active compounds in natural extracts, and characterization of species, and such studies require the acquisition of many diverse NMR measurements on series of samples.Although acquisition can easily be performed automatically, the number of NMR experiments involved in these studies increases very rapidly, and this data avalanche requires to resort to automatic processing and analysis.We present here a program that allows the autonomous, unsupervised processing of a large corpus of 1D, 2D, and diffusion-ordered spectroscopy experiments from a series of samples acquired in different conditions. The program provides all the signal processing steps, as well as peak-picking and bucketing of 1D and 2D spectra, the program and its components are fully available. In an experiment mimicking the search of a bioactive species in a natural extract, we use it for the automatic detection of small amounts of artemisinin added to a series of plant extracts and for the generation of the spectral fingerprint of this molecule.This program called Plasmodesma is a novel tool that should be useful to decipher complex mixtures, particularly in the discovery of biologically active natural products from plants extracts but can also in drug discovery or metabolomics studies. KEYWORDSautomatic processing, mixture analysis, recursive feature elimination, spectral fingerprint Magn Reson Chem. 2018;56:469-479.wileyonlinelibrary.com/journal/mrc

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2D-NMR investigation and in vitro evaluation of antioxidant, antigenotoxic and estrogenic/antiestrogenic activities of strawberry grape

Cited by 11 publications

References 33 publications

Antioxidant capacity and cytotoxic effect of an optimized extract of isabella grape (Vitis labrusca) on breast cancer cells

Antioxidant capacity and cytotoxic effect of an optimized extract of isabella grape (Vitis labrusca) on breast cancer cells

Theobromacacao Criollo var. Beans: Biological Properties and Chemical Profile

Automatic differential analysis of NMR experiments in complex samples

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