2017
DOI: 10.1016/j.fct.2017.03.050
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2D-NMR investigation and in vitro evaluation of antioxidant, antigenotoxic and estrogenic/antiestrogenic activities of strawberry grape

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Cited by 11 publications
(5 citation statements)
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“…Due to the biological protective effect that functional foods have on cancer development, Isabella grape has been studied as a potential chemopreventive and therapeutic agent for the treatment of different neoplasms. The chemopreventive mechanisms reported for this grape variety include cytotoxicity, cell cycle modulation, prooxidant action, apoptosis induction, and regulation of hormone receptors [ [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. At this point, it is worth mentioning that breast cancer is the most frequently diagnosed type of neoplasm worldwide [ 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Due to the biological protective effect that functional foods have on cancer development, Isabella grape has been studied as a potential chemopreventive and therapeutic agent for the treatment of different neoplasms. The chemopreventive mechanisms reported for this grape variety include cytotoxicity, cell cycle modulation, prooxidant action, apoptosis induction, and regulation of hormone receptors [ [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. At this point, it is worth mentioning that breast cancer is the most frequently diagnosed type of neoplasm worldwide [ 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, the increasing interest in plant-derived healthy natural products has been focused on the research for normally consumed food and drinks whose natural chemical composition provides multi-purpose beneficial effects [11,[33][34][35]. Thus, assuming that cocoa and derivatives are consumed frequently and widely all over the world as reported by Tokede and collaborators [36] due to the highly attractive organoleptic characteristics [4], herein the combined approach between the evaluation of various biological activities (radical scavenging, antimutagenicity, antigenotoxicity, and cancer cells viability inhibitory effect), and the chemical composition analysis by UHPLC-ESI QqTOF-MS/MS of the selected cocoa beans was used.…”
Section: Discussionmentioning
confidence: 99%
“…This capacity has been used in many analytical approaches: metabolomics, identification of bioactive compounds in natural extracts, and characterization of species. () See references Larive et al,() Mahrous et Farag() and Wolfender et al() for recent reviews.…”
Section: Introductionmentioning
confidence: 99%
“…All species in the solution display their NMR spectra, with a signal intensity proportional to their relative concentrations, provided that slow tumbling rates or relaxation agents do not hide the lines by fast relaxation processes. This capacity has been used in many analytical approaches: metabolomics, identification of active compounds in natural extracts, characterization of species [1][2][3][4][5] . See references (6), (7), and (8) for recent reviews.…”
Section: Introductionmentioning
confidence: 99%