2023
DOI: 10.1016/j.heliyon.2023.e16540
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Antioxidant capacity and cytotoxic effect of an optimized extract of isabella grape (Vitis labrusca) on breast cancer cells

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Cited by 2 publications
(2 citation statements)
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“…MCF-10A normal breast cells, which we found not being affected by E7 treatment (Figure 1), are also ER-beta-negative [50]. In a similar study investigating the cytotoxic effects of Vitis Labrusca extract on breast cancer cells, MCF-7 cells were also sensitive to treatment, whereas triple-negative MDA-MB-231 cells had no response to treatment [44]. Polyphenols, the main bioactive component of grape seeds extract, are known to bind to ERα and ERβ, and to exert properties that either mimic or antagonize the action of endogenous estrogens, even at low concentrations [51].…”
Section: Discussionsupporting
confidence: 53%
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“…MCF-10A normal breast cells, which we found not being affected by E7 treatment (Figure 1), are also ER-beta-negative [50]. In a similar study investigating the cytotoxic effects of Vitis Labrusca extract on breast cancer cells, MCF-7 cells were also sensitive to treatment, whereas triple-negative MDA-MB-231 cells had no response to treatment [44]. Polyphenols, the main bioactive component of grape seeds extract, are known to bind to ERα and ERβ, and to exert properties that either mimic or antagonize the action of endogenous estrogens, even at low concentrations [51].…”
Section: Discussionsupporting
confidence: 53%
“…In a study aimed to optimize the extraction methodology in Isabella grape (Vitis labrusca), the resulting extract showed antioxidant capacity and cytotoxicity in MCF-7 breast cancer cells. The TPC expressed as milligrams of gallic acid equivalents per gram of sample (mg GAE/g sample) was 43.14 ± 5.00 mg [44]. Overall, aqueous methanol has proved an effective solvent for isolation of total phenolics and flavonoids from Vitis vinifera leaves as well as for increased radical scavenging and antioxidant activities [26].…”
Section: Discussionmentioning
confidence: 95%