2D materials, synthesis, characterization and toxicity: A critical review

Naikoo, Gowhar A.; Arshad, Fareeha; Almas, Muniba; Hassan, Israr Ul; Pedram, Mona Zamani; Aljabali, Alaa A. A.; Mishra, Vijay; Serrano‐Aroca, Ángel; Birkett, Martin; Charbe, Nitin; Goyal, Rohit; Negi, Poonam; El‐Tanani, Mohamed; Tambuwala, Murtaza M.

doi:10.1016/j.cbi.2022.110081

Cited by 48 publications

(30 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Before experimental synthesis, the decomposition performance in water, the toxicity of As, and the surface stability of the β-AsP/g-C 6 N 6 heterostructure should be paid attention for practical applications. 66…”

Section: Resultsmentioning

confidence: 99%

A promising type-II β-AsP/g-C₆N₆ van der Waals heterostructure photocatalyst for water splitting: a first-principles study

Zhao

Jia

Guan

et al. 2022

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

A promising type-II β-AsP/g-C₆N₆ van der Waals heterostructure photocatalyst for water splitting: a first-principles study

Zhao

Jia

Guan

et al. 2022

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

show abstract

“…In the last decade, novel 2D nanomaterials with diverse characteristics have garnered exploding interest in the domains of biomedicine and other disciplines, where they play an increasingly crucial role [ 11 – 13 ]. These single or multilayer nano-crystalline materials with planar shape exhibit greater interatomic interactions than stacking interactions.…”

Section: Synthesis and Properties Of Black Phosphorusmentioning

confidence: 99%

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Zhao

Jiang

et al. 2023

J Biol Eng

View full text Add to dashboard Cite

Hydrogels, also known as three-dimensional, flexible, and polymer networks, are composed of natural and/or synthetic polymers with exceptional properties such as hydrophilicity, biocompatibility, biofunctionality, and elasticity. Researchers in biomedicine, biosensing, pharmaceuticals, energy and environment, agriculture, and cosmetics are interested in hydrogels. Hydrogels have limited adaptability for complicated biological information transfer in biomedical applications due to their lack of electrical conductivity and low mechanical strength, despite significant advances in the development and use of hydrogels. The nano-filler-hydrogel hybrid system based on supramolecular interaction between host and guest has emerged as one of the potential solutions to the aforementioned issues. Black phosphorus, as one of the representatives of novel two-dimensional materials, has gained a great deal of interest in recent years owing to its exceptional physical and chemical properties, among other nanoscale fillers. However, a few numbers of publications have elaborated on the scientific development of black phosphorus hybrid hydrogels extensively. In this review, this review thus summarized the benefits of black phosphorus hybrid hydrogels and highlighted the most recent biological uses of black phosphorus hybrid hydrogels. Finally, the difficulties and future possibilities of the development of black phosphorus hybrid hydrogels are reviewed in an effort to serve as a guide for the application and manufacture of black phosphorus -based hydrogels. Graphical Abstract Recent applications of black phosphorus hybrid hydrogels in biomedicine.

show abstract

“…Among the properties influencing the toxicities of 2-D inorganic materials are the number of layers, surface size, shape, and area [ 125 ]. Methods used for exfoliation and surface modification can also affect the toxicity of these 2-D materials [ 126 ]. Exfoliation can mitigate toxicity, as has been shown in a study of in-vitro toxicity for exfoliated versus aggregated MoS 2 [ 127 ].…”

Section: Factors Affecting Toxicitymentioning

confidence: 99%

“…Among the non-carbon 2-D nanomaterials, black phosphorus was found to be more toxic than metal dichalcogenides [ 130 ]. However, some of the dichalcogenides also contain tellurium (Te) or selenium (Se), which can be released from these materials in different environments and induce human and animal toxicity [ 126 ]. The toxicity of black phosphorus to bacteria and human cells, as well as, mice has been demonstrated previously due to induced oxidative stress and impairment in membrane integrity [ 131 ].…”

Section: Factors Affecting Toxicitymentioning

confidence: 99%

“…Nanomaterials of differing dimensions are utilized and combined into nanocomposite materials in biosensors [ 7 , 152 , 153 , 154 , 155 , 156 , 157 ], and thus, a deeper understanding of the effects of dimensionality via systematic study is needed. Toxicity associated with dimensionality has been discussed by reviews on individual 0-D [ 158 ], 1-D [ 158 ], 2-D [ 126 , 159 ], and 3-D materials [ 160 , 161 ]. However, it is difficult to determine the direct effect of dimensionality on toxicity.…”

Section: Factors Affecting Toxicitymentioning

confidence: 99%

See 1 more Smart Citation

Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors

et al. 2022

View full text Add to dashboard Cite

Biosensors often combine biological recognition elements with nanomaterials of varying compositions and dimensions to facilitate or enhance the operating mechanism of the device. While incorporating nanomaterials is beneficial to developing high-performance biosensors, at the stages of scale-up and disposal, it may lead to the unmanaged release of toxic nanomaterials. Here we attempt to foster connections between the domains of biosensors development and human and environmental toxicology to encourage a holistic approach to the development and scale-up of biosensors. We begin by exploring the toxicity of nanomaterials commonly used in biosensor design. From our analysis, we introduce five factors with a role in nanotoxicity that should be considered at the biosensor development stages to better manage toxicity. Finally, we contextualize the discussion by presenting the relevant stages and routes of exposure in the biosensor life cycle. Our review found little consensus on how the factors presented govern nanomaterial toxicity, especially in composite and alloyed nanomaterials. To bridge the current gap in understanding and mitigate the risks of uncontrolled nanomaterial release, we advocate for greater collaboration through a precautionary One Health approach to future development and a movement towards a circular approach to biosensor use and disposal.

show abstract

2D materials, synthesis, characterization and toxicity: A critical review

Cited by 48 publications

References 130 publications

A promising type-II β-AsP/g-C₆N₆ van der Waals heterostructure photocatalyst for water splitting: a first-principles study

A promising type-II β-AsP/g-C₆N₆ van der Waals heterostructure photocatalyst for water splitting: a first-principles study

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors

Contact Info

Product

Resources

About

2D materials, synthesis, characterization and toxicity: A critical review

Cited by 48 publications

References 130 publications

A promising type-II β-AsP/g-C6N6 van der Waals heterostructure photocatalyst for water splitting: a first-principles study

A promising type-II β-AsP/g-C6N6 van der Waals heterostructure photocatalyst for water splitting: a first-principles study

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors

Contact Info

Product

Resources

About

A promising type-II β-AsP/g-C₆N₆ van der Waals heterostructure photocatalyst for water splitting: a first-principles study

A promising type-II β-AsP/g-C₆N₆ van der Waals heterostructure photocatalyst for water splitting: a first-principles study