2D and 3D MOCART scoring systems assessed by 9.4 T high-field MRI correlate with elementary and complex histological scoring systems in a translational model of osteochondral repair

Goebel, Lars; Zurakowski, David; Müller, Andreas; Pape, Dietrich; Cucchiarini, Magali; Madry, Henning

doi:10.1016/j.joca.2014.05.027

Cited by 25 publications

(26 citation statements)

References 43 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Especially it allows to grade the entire cartilage defect at once, which is only achievable by histology if a large number of sections throughout the entire defect are evaluated. Previously, highly significant internal correlations of the five macroscopic scoring systems 3 as well as between the Sellers and Wakitani scores have been reported 6 , emphasizing the value of macroscopy to grade articular cartilage repair. High correlations for the structural categories "defect fill" and "integration" were detected when the macroscopic scoring systems were correlated with the elementary Wakitani and comprehensive Sellers scoring systems.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep

Goebel

Orth

Cucchiarini

et al. 2017

Osteoarthritis and Cartilage

Self Cite

View full text Add to dashboard Cite

Major individual morphological categories "defect fill" and "integration", and "total points" of macroscopic scoring systems correlate with their corresponding categories in elementary and complex histological scoring systems. Thus, macroscopy allows to precisely predict key histological aspects of articular cartilage repair, underlining the specific value of macroscopic scoring for examining cartilage repair.

show abstract

Section: Discussionmentioning

confidence: 92%

“…Highlighted in bolt and gray are parameters which can be correlated between macroscopy and histology. 3,6 . Specifically, correlations for key parameters such as "defect fill" and "total points" are existent, thus further strengthening the value of macroscopy to grade defect repair.…”

Section: Discussionmentioning

confidence: 99%

Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep

Goebel

Orth

Cucchiarini

et al. 2017

Osteoarthritis and Cartilage

Self Cite

View full text Add to dashboard Cite

show abstract

“…To do so, direct comparison of UBM and MRI on human would be required. Experimental high-field MRI at 9.4 T has been shown to allow reliable evaluation of explanted cartilage repair tissue in sheep, since it provides much better resolution (Goebel et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

3D ultrasound biomicroscopy for assessment of cartilage repair tissue: volumetric characterisation and correlation to established classification systems

Schöne

Männicke

Somerson

et al. 2016

eCM

View full text Add to dashboard Cite

Objective and sensitive assessment of cartilage repair outcomes lacks suitable methods. This study investigated the feasibility of 3D ultrasound biomicroscopy (UBM) to quantify cartilage repair outcomes volumetrically and their correlation with established classification systems. 32 sheep underwent bilateral treatment of a focal cartilage defect. One or two years post-operatively the repair outcomes were assessed and scored macroscopically (Outerbridge, ICRS-CRA), by magnetic resonance imaging (MRI, MOCART), and histopathology (O'Driscoll, ICRS-I and ICRS-II). The UBM data were acquired after MRI and used to reconstruct the shape of the initial cartilage layer, enabling the estimation of the initial cartilage thickness and defect volume as well as volumetric parameters for defect filling, repair tissue, bone loss and bone overgrowth. The quantification of the repair outcomes revealed high variations in the initial thickness of the cartilage layer, indicating the need for cartilage thickness estimation before creating a defect. Furthermore, highly significant correlations were found for the defect filling estimated from UBM to the established classification systems. 3D visualisation of the repair regions showed highly variable morphology within single samples. This raises the question as to whether macroscopic, MRI and histopathological scoring provide sufficient reliability. The biases of the individual methods will be discussed within this context. UBM was shown to be a feasible tool to evaluate cartilage repair outcomes, whereby the most important objective parameter is the defect filling. Translation of UBM into arthroscopic or transcutaneous ultrasound examinations would allow non-destructive and objective follow-up of individual patients and better comparison between the results of clinical trials.

show abstract

“…the Articular Cartilage imaging Group of the international Cartilage Repair society (iCRs) defined MoCARt, a set of pertinent variables for describing articular cartilage repair tissues after treatment using a biological repair technique (25); the MoCARt assesses the degree of defect repair and filling, the border zone integration, the surface, structure and signal intensity of the repair tissue, the subchondral lamina and bone, adhesions and effusion, and it gives a score ranging from 0 to 100. the MoCARt score was calculated on post-operative MRi 12 months after surgery by two independent orthopaedic surgeons blinded to the study. All MRi procedures were performed at 1.5t (MA -GnE toM Avanto, siemens Medical solution, Forchein, Germany, gradient strength 45 mt/m, slew rate 200 t/m/ms; MAGnEtoM Espree, siemens Medical solution, Forchein, Germany, gradient strength 33 mt/m, slew rate 170 t/m/ms), using standard imaging sequences and a dedicated extremity coil.…”

Section: Clinical and Imaging Evaluationmentioning

confidence: 99%

Treatment of osteochondral lesions of the talus with autologous collagen-induced chondrogenesis: clinical and magnetic resonance evaluation at one-year follow-up

Usuelli

Grassi

Manzi

et al. 2016

Joints

View full text Add to dashboard Cite

Purpose: the aim of this study is to report the clinical and imaging results recorded by a series of patients in whom osteochondral lesions of the talus (oLts) were repaired using the autologous collagen-induced chondrogenesis (ACiC) technique with a completely arthroscopic approach. Methods: nine patients (mean age 37.4±10 years) affected by oLts (lesion size 2.1±0.9 cm 2 ) were treated with the ACiC technique. the patients were evaluated clinically both preoperatively and at 12 months after surgery using the American orthopaedic Foot and Ankle society Ankle-Hindfoot scale (AoFAs) and a visual analog scale (VAs). For morphological evaluation, the magnetic resonance observation of cartilage repair tissue (MoCARt) score was used. Results: the AoFAs score improved from 51.4±11.6 preoperatively to 71.8±20.6 postoperatively, while the VAs value decreased from 6.9±1.8 to 3.2±1.9. the mean MoCARt score was 51.7±16.6 at 12 months of follow-up; these scores did not directly correlate with the clinical results. Conclusion: use of the ACiC technique for arthroscopic repair of oLts allowed satisfactory clinical results to be obtained in most of the patients as soon as one year after surgery, with no major complications or delayed revision surgery. ACiC is a valid and lowinvasive surgical technique for the treatment of chondral and osteochondral defects of the talus. Level of evidence: therapeutic case series, level iV.

show abstract

2D and 3D MOCART scoring systems assessed by 9.4 T high-field MRI correlate with elementary and complex histological scoring systems in a translational model of osteochondral repair

Cited by 25 publications

References 43 publications

Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep

Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep

3D ultrasound biomicroscopy for assessment of cartilage repair tissue: volumetric characterisation and correlation to established classification systems

Treatment of osteochondral lesions of the talus with autologous collagen-induced chondrogenesis: clinical and magnetic resonance evaluation at one-year follow-up

Contact Info

Product

Resources

About