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Abstract

Hepatocellular Carcinoma (HCC), the primary liver cancer, is the third leading cause of most cancer related mortality worldwide. The canonical Wnt/β-catenin signaling pathway is found deregulated in most HCC and makes an attractive therapeutic target. β-catenin is the key effector of Wnt signaling pathway.In the present study, an attempt was made to evaluate the binding mode of some phytoestrogens found in dried fruits such as raisin and dates, to β-catenin in the wnt signaling pathway. The structural coordinates for the compounds used as ligands were retrieved from the PubChem chemical structure database. Based on Lipinski rule of five for druglikeness, the compounds were filtered and used as ligands in the docking analysis using CDocker. Results show that Secoisolariciresinol formed an interaction with β catenin with a least binding energy value of -35.1622Kcal/mol. The study provides a molecular insight into the binding mode of some phytoestrogens found in dried fruits that can be a potential drug candidate to β-catenin while targeting the Wnt signaling for HCC therapy.