Mania-like elevated mood in rats: Enhanced 50-kHz ultrasonic vocalizations after sleep deprivation

Wendler, Etiéli Mara; Souza, Camila Pasquini de; Dornellas, Ana Paula Segantine; Santos, Luís Eduardo; Ferreira, Sérgio T.; Galduróz, José Carlos Fernandes; Wöhr, Markus; Schwarting, Rainer K.W.; Andreatini, Roberto

doi:10.1016/j.pnpbp.2018.07.002

Cited by 25 publications

(32 citation statements)

References 69 publications

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“…show that SD induces hyperlocomotion and increases in rearings and 50-kHz USV emission in rats, which denotes manic-like behaviors, showing face validity of the model (Wendler et al, 2019). Psychostimulants seem to induce increased 50-kHz USVs by D1 and D2 receptor activation (Rippberger et al, 2015), and this agrees with the pivotal role of increased dopaminergic neurotransmission in mania (Ashok et al, 2017).…”

Section: Discussionsupporting

confidence: 58%

“…The induction of SD and the administration of methylphenidate are considered to be valid animal models of mania, as they show face, construct and predictive validity . After 24h SD, animals show insomnia, hyperactivity, irritability, aggressiveness, hypersexuality, and stereotypy, which are behaviors also seen in humans after SD , and increases in the emission of 50-kHz ultrassonic vocalizations (USVs) (Wendler et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…The objective of the protocol is that, when animals standing in platforms surrounded by water for 24h, 72h or 96h, reach REM sleep, they display muscle relaxation, falling into the water and, thus, having their sleep interrupted . After this period of SD, animals show some behaviors such as hyperlocomotion and an increase in appetitive USVs, which can be correlated with manic-like behaviors (Wendler et al, 2019;.…”

Section: Sleep Deprivation (Sd)-induced Manic-like Behaviormentioning

confidence: 99%

“…Wendler et al (2016) used LDX administration as model of mania to induce increases in 50-kHz USVs in rats. Studies show that psychostimulants and SD induce increases in 50-kHz USVs in rats, which can be inhibited by drugs used in the management of BD, such as antipsychotics and lithium (Wendler et al, 2019;Wendler et al, 2016;Barker et al, 2015;Rippberger et al, 2015;. Therefore, the evaluation of the effects of drugs on psychostimulant (e.g., LDX)-induced increases in 50-kHz USVs is of great relevance in the research for antimanic drugs.…”

Section: Lisdexamfetamine (Ldx)-induced Increases In 50-khz Usvsmentioning

confidence: 99%

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The antimanic-like effects of andrographolide and quercetin

Kanazawa¹

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Sleep Deprivation (Sd)-induced Manic-like Behaviormentioning

confidence: 99%

Section: Lisdexamfetamine (Ldx)-induced Increases In 50-khz Usvsmentioning

confidence: 99%

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The antimanic-like effects of andrographolide and quercetin

Kanazawa¹

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“…Moreover, flanking evidence in support of the notion that 50-kHz USV could serve as marker for mania-elevated mood was obtained in a study on sleep deprivation (Wendler et al, 2019). Sleep deprivation is a widely applied environmental model for mania (Kara &Einat, 2013, Logan andMcClung, 2016;Sharma et al, 2016;Young et al, 2011).…”

Section: Mania-elevated Mood and 50-khz Ultrasonic Vocalizationsmentioning

confidence: 88%

Measuring mania‐like elevated mood through amphetamine‐induced 50‐kHz ultrasonic vocalizations in rats

Wöhr

2021

British J Pharmacology

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Rats emit 50-kHz ultrasonic vocalizations (USV) in appetitive situations, reflecting a positive affective state. Particularly high rates of 50-kHz USV are elicited by the psychostimulant d-amphetamine (AMPH). Exaggerated 50-kHz USV emission evoked by AMPH is modulated by dopamine, noradrenaline, and serotonin receptor ligands and inhibited by the mood stabilizer lithium, the gold standard anti-manic drug for treating bipolar disorder. This indicates that exaggerated 50-kHz USV emission can serve as a reliable and valid measure for assessing mania-like elevated mood in rats with sufficient translational power for gaining a better understanding of relevant pathophysiological mechanisms and the identification of new therapeutic targets. The improved capacity to study the effects of anti-manic pharmacological interventions on a broader range of behaviors by including exaggerated 50-kHz USV emission as preclinical outcome measure complementary to locomotor hyperactivity will refine rodent models for mania.

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