Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis

Colboc, Hester; Moguelet, Philippe; Bazin, Dominique; Bachmeyer, Claude; Frochot, Vincent; Weil, Raphaël; Letavernier, Emmanuel; Jouanneau, Chantal; Daudon, Michel; Bernaudin, Jean-François

doi:10.1111/jdv.15167

Cited by 21 publications

(25 citation statements)

References 18 publications

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“…Also, some dermatology reports provide complementary insights. In a recent study on 14 consecutive patients with cutaneous sarcoidosis, Colboc et al identified crystalline silica inside granulomas in biopsies of three patients. Furthermore, whereas traumatic skin exposure to silica induces an initial foreign body granulomatous reaction—with a predominantly macrophage response and rapid resolution—in all individuals, several case reports have described that in some susceptible individuals, after a latent interval of years, a delayed hypersensitivity‐type granulomatous response occurs—with a histological picture identical to that of sarcoidosis …”

Section: Discussionmentioning

confidence: 99%

Granulomatous lung disease in two workers making light bulbs

Ronsmans

Verbeken

Adams

et al. 2019

American J Industrial Med

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Section: Discussionmentioning

confidence: 99%

Granulomatous lung disease in two workers making light bulbs

Ronsmans

Verbeken

Adams

et al. 2019

American J Industrial Med

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“…Although rather a mineralisation than a biological calcification, silicon dioxide-or silica-is found in skin in the case of sarcoidosis [76,77] and also in kidney [78]. The chemistry of silica has been studied intensively due its importance in heterogeneous catalysis [79], yet not often at DFT level.…”

Section: Outlook On Silica Dft Studiesmentioning

confidence: 99%

Opportunities given by density functional theory in pathological calcifications

Tielens¹,

Vekeman²,

Bazin³

et al. 2022

Comptes Rendus. Chimie

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Density Functional Theory has made the study of biomaterials feasible in the past years leading to better understanding of causes and possible treatments of related pathologies. Although it has been successfully applied in many fields, it has not yet consistently found its way into the field of pathological calcifications. An overview will be given of the studies where this technique has been applied in order to outline the important contributions that it can bring in the field of biomineralization. More specifically, studies on DFT calcifications from calcium oxalates and calcium phosphates, with relevance to bone formation and kidney stones, will be reviewed. Finally, a short outlook on silica mineralization will be presented as well.

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“…8 Nanotechnologies are receiving increased attention to improve understanding of the effects of pathologic deposits on living tissues. 9,10 The aims of this study were to determine precisely the localization, morphologic features, and chemical composition of calcifications in the skin of patients with CUA, and then examine whether any association could be established between their microscopy findings and clinical characteristics.…”

mentioning

confidence: 99%

Localization, Morphologic Features, and Chemical Composition of Calciphylaxis-Related Skin Deposits in Patients With Calcific Uremic Arteriolopathy

et al. 2019

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; for the Groupe Angio-Dermatologie of the French Society of Dermatology IMPORTANCE Calcific uremic arteriolopathy (CUA), a rare, potentially fatal, disease with calcium deposits in skin, mostly affects patients with end-stage renal disease who are receiving dialysis. Chemical composition and structure of CUA calcifications have been poorly described. OBJECTIVES To describe the localization and morphologic features and determine the precise chemical composition of CUA-related calcium deposits in skin, and identify any mortality-associated factors. DESIGN, SETTING, AND PARTICIPANTS A retrospective, multicenter cohort study was conducted at 7 French hospitals including consecutive adults diagnosed with CUA between January 1, 2006, and January 1, 2017, confirmed according to Hayashi clinical and histologic criteria. Patients with normal renal function were excluded. For comparison, 5 skin samples from patients with arteriolosclerosis and 5 others from the negative margins of skin-carcinoma resection specimens were also analyzed. MAIN OUTCOMES AND MEASURES Localization and morphologic features of the CUA-related cutaneous calcium deposits were assessed with optical microscopy and field-emissionscanning electron microscopy, and the chemical compositions of those deposits were evaluated with μ Fourier transform infrared spectroscopy, Raman spectroscopy, and energy dispersive radiographs. RESULTS Thirty-six patients (median [range] age, 64 [33-89] years; 26 [72%] female) were included, and 29 cutaneous biopsies were analyzed. Calcific uremic arteriolopathy and arteriolosclerosis skin calcifications were composed of pure calcium-phosphate apatite. Calcific uremic arteriolopathy vascular calcifications were always circumferential, found in small to medium-sized vessels, with interstitial deposits in 22 (76%) of the samples. A thrombosis, most often in noncalcified capillary lumens in the superficial dermis, was seen in 5 samples from patients with CUA. Except for calcium deposits, the vessel structure of patients with CUA appeared normal, unlike thickened arteriolosclerotic vessel walls. Twelve (33%) patients died of CUA. CONCLUSIONS AND RELEVANCE Calcific uremic arteriolopathy-related skin calcifications were exclusively composed of pure calcium-phosphate apatite, localized circumferentially in small to medium-sized vessels and often associated with interstitial deposits, suggesting its pathogenesis differs from that of arteriolosclerosis. Although the chemical compositions of CUA and arteriolosclerosis calcifications were similar, the vessels' appearances and deposit localizations differed, suggesting different pathogenetic mechanisms.

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Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis

Cited by 21 publications

References 18 publications

Granulomatous lung disease in two workers making light bulbs

Granulomatous lung disease in two workers making light bulbs

Opportunities given by density functional theory in pathological calcifications

Localization, Morphologic Features, and Chemical Composition of Calciphylaxis-Related Skin Deposits in Patients With Calcific Uremic Arteriolopathy

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