In situ fabrication of mesoporous silica-coated silver-gold hollow nanoshell for remotely controllable chemo-photothermal therapy via phase-change molecule as gatekeepers

Poudel, Bijay Kumar; Soe, Zar Chi; Ruttala, Hima Bindu; Gupta, Biki; Ramasamy, Thiruganesh; Thapa, Raj Kumar; Gautam, Milan; Ou, Wenquan; Nguyen, Hanh Thuy; Jeong, Jee‐Heon; Jin, Sung Giu; Choi, Han‐Gon; Yong, Chul Soon; Kim, Jong Oh

doi:10.1016/j.ijpharm.2018.06.056

Cited by 52 publications

(19 citation statements)

References 36 publications

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“…The almost complete disappearance of peaks at 2,800–3,200 cm −1 and 1,470 cm −1 confirmed the successful removal of CTAC template from MSNs 58. The template can be also removed using sodium chloride-methanolic solution procedure 59. The FTIR spectrum of MSNTQ displayed two new bands at 1,380 and 1,641cm −1 , corresponding to TQ, and the intensity bands at 2,934 and 3,340 cm −1 increased.…”

Section: Resultsmentioning

confidence: 99%

Targeted anticancer potential against glioma cells of thymoquinone delivered by mesoporous silica core-shell nanoformulations with pH-dependent release

Shahein

Aboul‐Enein

Higazy

et al. 2019

IJN

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Background and purpose Glioma is one of the most aggressive primary brain tumors and is incurable. Surgical resection, radiation, and chemotherapies have been the standard treatments for brain tumors, however, they damage healthy tissue. Therefore, there is a need for safe anticancer drug delivery systems. This is particularly true for natural prodrugs such as thymoquinone (TQ), which has a high therapeutic potential for cancers but has poor water solubility and insufficient targeting capacity. We have tailored novel core-shell nanoformulations for TQ delivery against glioma cells using mesoporous silica nanoparticles (MSNs) as a carrier. Methods The core-shell nanoformulations were prepared with a core of MSNs loaded with TQ (MSNTQ), and the shell consisted of whey protein and gum Arabic (MSNTQ-WA), or chitosan and stearic acid (MSNTQ-CS). Nanoformulations were characterized, studied for release kinetics and evaluated for anticancer activity on brain cancer cells (SW1088 and A172) and cortical neuronal cells-2 (HCN2) as normal cells. Furthermore, they were evaluated for caspase-3, cytochrome c, cell cycle arrest, and apoptosis to understand the possible anticancer mechanism. Results TQ release was pH-dependent and different for core and core-shell nanoformulations. A high TQ release from MSNTQ was detected at neutral pH 7.4, while a high TQ release from MSNTQ-WA and MSNTQ-CS was obtained at acidic pH 5.5 and 6.8, respectively; thus, TQ release in acidic tumor environment was enhanced. The release kinetics fitted with the Korsmeyer–Peppas kinetic model corresponding to diffusion-controlled release. Comparative in vitro tests with cancer and normal cells indicated a high anticancer efficiency for MSNTQ-WA compared to free TQ, and low cytotoxicity in the case of normal cells. The core-shell nanoformulations significantly improved caspase-3 activation, cytochrome c triggers, cell cycle arrest at G2/M, and apoptosis induction compared to TQ. Conclusion Use of MSNs loaded with TQ permit improved cancer targeting and opens the door to translating TQ into clinical application. Particularly good results were obtained for MSNTQ-WA.

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Section: Resultsmentioning

confidence: 99%

Targeted anticancer potential against glioma cells of thymoquinone delivered by mesoporous silica core-shell nanoformulations with pH-dependent release

Shahein

Aboul‐Enein

Higazy

et al. 2019

IJN

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“…Thanks to their intrinsic anticancer activity [ 93 ], AgNPs attracted special attention for this particular domain, and were successfully evaluated as effective anti-tumor drug-delivery systems [ 94 ], acting either as passive [ 95 , 96 ] or active [ 97 , 98 ] nanocarriers for anticancer drugs. For the preparation of biocompatible AgNPs, different strategies were used, such as organic-water two-phase synthesis [ 99 , 100 , 101 ], micro-emulsion [ 102 , 103 , 104 ], radiolysis [ 105 , 106 ], and most commonly, reduction in aqueous solution [ 94 , 107 , 108 ].…”

Section: Silver Nanoparticles For Drug-delivery Systemsmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

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During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.

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“…These are nanoparticles such as silver nanoparticles (AgNPs), gold nanoparticles (AuNPs) (Figure 19), 260 nanoparticles and titanium dioxide nanoparticles (TiO 2 ) possess special benefits in biomedical application due to their contents of essential mineral elements that have strong activity for human body. 261 These nanoparticles gained their noncovalent interaction or covalent conjugation drug-loading capacity due to their surface plasmon resonance (SPR) ability, structural diversity, poor toxicity, and high biocompatibility. Thus, they can be utilized for achieving intracellular drug delivery and controlled release through a photothermal route.…”

Section: Metal Nanoparticle (Mn)mentioning

confidence: 99%

Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications

Rahman

Othman

Hammadi

et al. 2020

IJN

145

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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In situ fabrication of mesoporous silica-coated silver-gold hollow nanoshell for remotely controllable chemo-photothermal therapy via phase-change molecule as gatekeepers

Cited by 52 publications

References 36 publications

<p>Targeted anticancer potential against glioma cells of thymoquinone delivered by mesoporous silica core-shell nanoformulations with pH-dependent release</p>

<p>Targeted anticancer potential against glioma cells of thymoquinone delivered by mesoporous silica core-shell nanoformulations with pH-dependent release</p>

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

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