Delayed Socket Healing After Dental Extraction in Patients Undergoing Myelosuppressive Chemotherapy for Hematological Malignancy: Incidence and Risk Factors

Akashi, Mitsuru; Kishimoto, Megumi; Kusumoto, Junya; Yakushijin, Kimikazu; Matsuoka, Hiroshi; Komori, Takahide

doi:10.1016/j.joms.2018.05.023

Cited by 6 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 200-μL mixture was loaded into the wells of the plate. For assessing the effect of CCL2, the human recombinant CCL2 (rhCCL2) (#HY-P7237; MedChemExpress, Monmouth Junction, NJ, USA) were added into HUVECs in different concentrations (1,5,10,50, and 100 ng/mL) to find the effective concentration. Then, the indicated cells were treated with the effective concentration (100 ng/mL) of rhCCL2.…”

Section: Cell Culture and CM Preparationmentioning

confidence: 99%

“…The incidence of delayed socket healing after tooth extraction is approximately 7.5%. ( 1 ) Delayed healing and dimensional loss of the alveolar ridge make subsequent treatment difficult because they further impair occlusal function and have negative aesthetic consequences. ( 2 ) Anorganic bovine bone, guided bone regeneration, platelet‐rich plasma, and autogenous bone grafts are the most common methods used to stimulate socket healing.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kangfuxin Accelerates Extraction Socket Healing by Promoting Angiogenesis Via Upregulation of CCL2 in Stem Cells

Gao

Zhou

Zhao

et al. 2023

J of Bone & Mineral Res

View full text Add to dashboard Cite

Kangfuxin (KFX) shows potential in wound healing, but its role in socket healing is unclear. This research finds increased bone mass, mineralization, and collagen deposition in KFX‐treated mice. Mouse bone marrow mesenchymal stem cells, human periodontal ligament stem cells (hPDLSCs), and human dental pulp stem cells (hDPSCs) are treated with KFX under osteogenic induction. RNA‐sequencing reveals upregulated chemokine‐related genes, with a threefold increase in chemokine (C‐C motif) ligand 2 (Ccl2). The conditioned medium (CM) of hPDLSCs and hDPSCs treated with KFX promotes endothelial cell migration and angiogenesis. Ccl2 knockdown abolishes CM‐induced endothelial cell migration and angiogenesis, which can be reversed by recombinant CCL2 treatment. KFX‐treated mice showed increased vasculature. In conclusion, KFX increases the expression of CCL2 in stem cells, promoting bone formation and mineralization in the extraction socket by inducing endothelial cell angiogenesis. © 2023 American Society for Bone and Mineral Research (ASBMR).

show abstract

Section: Cell Culture and CM Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kangfuxin Accelerates Extraction Socket Healing by Promoting Angiogenesis Via Upregulation of CCL2 in Stem Cells

Gao

Zhou

Zhao

et al. 2023

J of Bone & Mineral Res

View full text Add to dashboard Cite

show abstract

“…If the patient is already receiving systemic therapy, invasive dental procedures are appropriate during periods of remission or between chemotherapy cycles while cell and platelet counts are at their optimum. Accordingly, Akashi et al did not detect any rebleeding events when platelet counts were > 50,000/μL and topical hemostyptics were used [ 62 ].…”

Section: Literature Review On Bleeding Disorders In Dentistrymentioning

confidence: 99%

Bleeding disorders in implant dentistry: a narrative review and a treatment guide

et al. 2022

View full text Add to dashboard Cite

Purpose Considering a high prevalence of congenital and especially acquired bleeding disorders, their heterogeneity and the multitude of possible treatments strategies, a review of the scientific data on this topic is needed to implement a treatment guide for healthcare professionals. Methods A selective literature review was performed via PubMed for articles describing oral surgery / dental implant procedures in patients with congenital and acquired bleeding disorders. Out of the existing literature, potential treatment algorithms were extrapolated. Results In order to assess the susceptibility to bleeding, risk stratification can be used for both congenital and acquired coagulation disorders. This risk stratification, together with an appropriate therapeutic pathway, allows for an adequate and individualized therapy for each patient. A central point is the close interdisciplinary cooperation with specialists. In addition to the discontinuation or replacement of existing treatment modalities, local hemostyptic measures are of primary importance. If local measures are not sufficient, systemically administered substances such as desmopressin and blood products have to be used. Conclusions Despite the limited evidence, a treatment guide could be developed by means of this narrative review to improve safety for patients and practitioners. Prospective randomized controlled trials are needed to allow the implementation of official evidence-based guidelines.

show abstract

“…Collagen sponges when used in burns and ulcers (decubitus ulcers) have the ability to absorb large quantities of tissue exudates, blood, and saliva and present the benefit to adhere to the wet wounds and by clouting to facilitate the dermal and epidermal wound healing. Piroxicamcollagen sponges could also be used as the delivery system for intravaginal wounds or cervical dysplasia [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Piroxicam-Collagen-Based Sponges for Medical Applications

Ioan

Rău

Tihan

et al. 2019

International Journal of Polymer Science

View full text Add to dashboard Cite

Depending on the concentration of the drug and/or the method of administration, drugs could be used in various ways. To take full advantage of the drug beneficial properties in oral medical interventions but also in other types of surgery, like plastic surgery, general surgery, or gynecological surgery, the drug concentration as well as the administration method itself will depend on the wound, type of surgery, and severity of the postoperative pain which can be very different. Generally, the local administration methods are recommended. Piroxicam, a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class, is generally used to relieve the symptoms of pain and inflammation. Starting from the idea of the special benefit of the interference between collagen-based materials and drug beneficial properties, our work was focused on the synthesis and characterization of new collagen-piroxicam materials. These new collagen-based materials present a good water absorption, and the piroxicam release suggests a biphasic drug release profile whereas the obtained values for the release exponent revealed a complex release mechanism including swelling, diffusion, and erosion.

show abstract

Delayed Socket Healing After Dental Extraction in Patients Undergoing Myelosuppressive Chemotherapy for Hematological Malignancy: Incidence and Risk Factors

Cited by 6 publications

References 32 publications

Kangfuxin Accelerates Extraction Socket Healing by Promoting Angiogenesis Via Upregulation of CCL2 in Stem Cells

Kangfuxin Accelerates Extraction Socket Healing by Promoting Angiogenesis Via Upregulation of CCL2 in Stem Cells

Bleeding disorders in implant dentistry: a narrative review and a treatment guide

Piroxicam-Collagen-Based Sponges for Medical Applications

Contact Info

Product

Resources

About